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Flashcards in 9/27 Deck (72)
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1

what immunosuppression drug is mainly used for solid organ transplants and inhibits T cella activation

Cyclosporin

2

anticholinergic that treats drug induced parkinsonism

Benztropine

3

what is the mixing of genomic segments in segmented viruses that affect the host cell called

reassortment

4

what is it called when a host cell is infected with 2 viral strains and progeny irons contain unchanged parental genome from one strain and nucleocapsid proteins from the other strain

phenotypic mixing

5

what is it called when there is gene exchange from the crossing over of 2 double stranded DNA molecules

recombination

6

what is the uptake of naked DNA by a prokaryote or eukarytoci cell

transformation

7

incorporation of viral DNA into a host cell chromosome is known as

transformation

8

what is acute cholecystitis caused by

obstruction by a gall stone

9

what gives similar results on repeat measurements and is reproducible

reliable test

10

ability for test to measure what it is supposed to measure is known as

validity ( accuracy)

11

dura mater ends at what level

S2

12

what is the bony attachment site for the sartorius muscle

anterior superior iliac spine

13

what is the bony attachment site for the sacrotuberous and posterior sacroiliac ligaments in the iliac crest

posterior superior iliac spine

14

inactivation of the HFE protein causes

hemochromatosis

15

why does inactivation of the HFE protein cause hemochromatosis

because hepcidin is decreased and the hepatocytes have an increased expression of DMT1 by enterocytes that lead to iron overload

16

patients with hemochromatosis are at an increased risk for what

liver cirrhosis and hepatocellualr carcinoma

17

what protein is known to interact with transferrin receptor to sense iron stores

HFE protein

18

what is bronze diabetes

when body iron level exceed 20 g and there is a triad of
- diabetes mellitus
- skin pigmentation
- micro nodular cirrhosis

19

what is an Anti IgE antibody that is given to people with moderate to severe allergic asthma

omalizumab

20

what is Bortezomib

a proteasome inhibitor that is used in the treatment of multiple myeloma and Waldenstrom Macroglobulinemia

21

name 3 anti TNF-a drugs

infliximab
Etanercept
Golimumab

22

40 s subunit of ribosomes does what

binds mRNA and tRNA

23

60s subunit of ribosomes does what

has peptide transferase which is the enzyme that causes peptide bond formation between amino acids ( protein synthesis)

24

how do ribosomes attach to the RER

via the translocon which is a protein complex that contains ribophorins that bind the large 60s subunit

25

what do the lamellar bodies of type 2 pneumocytes do

they store and release pulmonary surfactant into the fluid layer lining the alveoli

26

where do goblet cells end in the air way

larger bronchioles, then club cells take over

27

particles that lodge distally to the terminal bronchioles where there is no cilia present is cleared by

macrophages

28

what stimulates the granuloma cells inside the follicle to produce estrogen which leads to the rise of estrogen seen in the follicular stage of the menstrual cycle

FSH

29

where is androstenedione synthesized in women

in the theca cells and turned into estrogen in the granuloma cells

30

there is an increased activity of what cells in Crohns Disease

TH 1 cells ( IFN-y, TNF and IL-2)