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Flashcards in Pharm Deck (58):
1

Name some drugs that should be avoided in the elderly

Antihistamines (benydryl)
TCA's
Benzo
Sulfonylureas
Indimethicin

2

Drug of choice for the treatment of paroxysmal supra ventricular tachycardia

Adenosine

3

Action of adenosine

Slows conduction through the AV node by hyper polarizing the nodal pacemaker and conducting cells

4

Side effects of adenosine

Flushing, chest burning (bronchi spams ) and hypotension

5

Drug used for chemical cardiac stress test

Adenosine

6

Name two drugs that are metabolized by methylation

6-MC
Azathioprine

7

Name a syndrome associated with a dysfunction of glucuronyl transferase system that can lead to the toxic accumulation of some drugs because of the lack of glucuronidation

Gilbert syndrome

8

Bilirubin is metabolized by what method

Glucuronidation

9

Chest pain that occurs with activity only

Stable angina

10

Why avoid nitrates in HOCM

Because they decrease left ventricular volume which worsens left ventricular tract obstruction which worsens the situation

11

Raynuad is associated with what drugs

Amphetamines
Ergotamine
Chemo drugs

12

The ability for a drug to illicit and effect?

Efficacy

13

The dose of a drug that is needed to produce a given effect

Potency

14

Lower ED 50 means what?

A greater amount of potency

15

What does the stimulation of D1 do

Raises cAMP and causes vasodilation in most arterial beds and decreases BP

16

What is a D1 receptor short acting agonist used in severe HtN

Fenoldopam

17

A drug that causes renal vasodilation and increases naturesis. Mainly used for HTN emergency

Fenoldopam

18

Name a drug that is responsible for inhibiting GP 2b/3a from binding to fibrinogen stabilizing a platlet plug

Abciximab

19

What does Argatroban treat

Heparin induced thrombocytopenia

20

How does clopidgrel block platlet Adp receptors

By blocking P2Y12

21

Three drugs that can cause aplastic anemia

Carbamazepine
Chloramphenicol
Sulfonamides

22

Side effects of gentamicin

Vestibular and cochlear ototoxicity and nephrotoxicity

23

What happens when metronidazole is taken with alcohol

Disulfiram like reaction

24

What is used for heparin reversal

Protamine

25

At high doses what does desmopressin do

Increases factor eight activity in hemophilia a and Von willebrand disease patients

26

Drug thy treats hyperemesis gravidarum

Promethazine (antihistamine drug)

27

Antihistamine drugs that treat vomiting

Diphenhydramine
Meclizine
Promethazine

28

Dopamine receptor antagonist drugs that treat vomit

Prochlorperazine
Metoclorpramide

29

Neurokin 1 receptor antagonist that treat chemo associated vomiting

Aprepitant
Fosaprepitant

30

Five receptors associate with the area prostrema (vomiting)

M1
D2
H1
Serotonin
Neurokinin 1

31

A drug that is a motilin that is used for gastroparesis

Erythromycin

32

What is the neurotransmitter that plays a role in pain and appetite and is found in the ANS

Neuropeptide Y

33

Ganciclovir treats CMV and had a UDE of what

Neutropenia

34

Adding TMP-SMX to ganciclovir causes what

Bone marrow suppression

35

Didansoine is an antiretroviral drug that can cause what adverse reaction

Pancreatitis

36

What are plasma cells susceptible to

Proteosome inhibitors called
Bortezomib
Boronic acid containing dipeptide
(Induce apoptosis in malignant plasma cells)

37

Heparin induced thrombocytopenia leads to thrombosis not bleeding and is associated with antibodies to what

Factor 4 and heparin

38

Decreased factor 8 is associated with hemophilia?

A

39

Decreased factor nine is associated with hemophilia?

B

40

People with hemophilia a can control bleeding with what

DDAVP (desmopressin)

41

Drug of choice for beta blocker overdose

Glucagon

42

Action of glucagon on the heart

It increases cAMP and increases heart rate and contractility

43

Burning in urination and urgency is a side effect associated with what anti cancer drug

Cyclophosphamide

44

Ant cancer drug that causes progressive pulmonary fibrosis that can cause death in some patients

Bleomycin

45

Mercaptoourine is associated with what side effect

Jaundice and abdominal pain

46

Monoclonal antibody used for RA and Ankylosing Spondylitis (antibody against TNF alpha)

Infliximab

47

IL 2 treats what two things

Renal cell carcinoma and melanoma

48

Drug that inhibits BCR/ABL AND treats CmL

Imatinib

49

What turns Uric acid into allantoin which is more soluble then Uric acid. Used in tumor lysis syndrome

Rasburicase

50

Drug used to counter methotrexate induced block of folic acid metabolism

Folinic acid (leucovorin)

51

What activates 6MCP

hGPRT

52

What inactivated 6MCP

Xanthine oxidase

53

What is the use for Cladribine

Hair cell leukemia (resistant to the degradation of ADA)

54

What is a drug that can cause prolonged QT but not likely to cause torsades de pointes

Amiodarone

55

What to give to partners with aspirin allergy who need a cardio protective drug

Clopidgrel

56

What drug causes an increases in LDl cholesterol and triglycerides because it increases insulin resistance in peripheral tissue

Thiazides

57

hormones that use cAMP

- TSH
-ACTH
-HCG

58

what is P-glycoprotein

it is a human multi drug resistance transmembrane ATP-dependent efflux pump protein that reduces the influx of drugs into the CNS, blocking the action of chemotherapeutic agents