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Flashcards in Endocrine Deck (74)
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1

What test should you order before giving metformin

Creatine test

2

What happens to pro insulin in the RER

It is added to three disulfide bonds and transported to the Golgi and packed into secretary granules

3

The cleavage of what by endopeptidases in the secretory granules results in the formation of insulin and c peptide

Pro insulin

4

Uptake of cholesterol happens how

Receptor mediated endocytosis (mediated by LDL receptor)

5

How does glucose get into cells

Facilitated diffusion with the use of GLUT transporters

6

medullary thyroid carcinoma has increased levels of what

calcitonin

7

what are the gremlin mutations seen in MEN 2

RET

8

Marfanoid, mucosal neuroma, pheochromocytoma, medullary thyroid carcinoma?

MEN 2B

9

medullary thyroid carcinoma, pheochromocytoma, parathyroid hyperplasia

MEN 2A

10

hyperparathyroidism, pituitary tumor
and pancreatic tumor

MEN 1

11

RAS mutations are found in what

follicular thyroid cancer and some follicular adenomas

12

what is the treatment for CAD

giving low doses of cortisol to suppress ACTH secretion

13

what is the best marker test for hypothyroidism

high TSH ( this will be high before you see low T3 and T4)

14

why does the metabolism of alcohol for long periods of time cause hypoglycemia

Alcohol DH and Acetaldehyde DH reduce NAD to NADH and this increases the NADH/NAD Ratio, making impossible for reactions that need NAD to work, such as gluconeogensis

15

what binds to potassium in the pancreas to release insulin

ATP

16

protein defect in familial Chylomicronemia Syndrome

Lipoprotein Lipase and ApoC-2

17

major manifestations of Familial Chylomicronemia Syndrome

Acute Pancreatitis
Eruptive skin Xanthomas

18

protein defect in familial hypercholesterolemia

LDL receptor
APOB-100

19

manifestations in familial hypercholesterolemia

premature coronary artery disease

20

protein defect in familial dysbetalipiproteinemia

ApoE

21

manifestation in familial dysbetalipiproteinemia

premature coronary artery disease

22

protein defect in familial hypertriglyceridemia

ApoA-V

23

what is lipoprotein lipase usually bound too

heparin sulfate

24

milky appearing renal vascular is seen in familial chylomicronemia syndrome and is called what

lipema retinalis

25

what are the carrier proteins for OCT and ADH

neurophysins

26

what is the signaling pathway that GH uses to release IGF-1 from the liver

Jak Stat Pathway

27

what is it called when there is an aldosterone secreting tumor and there is a rise in sodium and a fall in hydrogen and potassium

Conn syndrome

28

DKA can cause something in patients that is associated with the respiratory alkalosis they experience to combat the acidosis

respiratory failure

29

biopsy of subacute granulomatous thyroiditis

multinuclear giant cels with lymphocytic infiltration

30

biopsy of papillary thyroid cancer

branching papillary structures with concentric calcifications