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Flashcards in RENAL Deck (17):
1

- generalized reabsorption defect in the PCT
- increased excretion of all amino acids, glucose, bicarb, and phosphate
- can cause metabolic acidosis
- due to wilson disease, tyrosinemia, and cystinosis

fanconi syndorme

2

what drugs cause fanconi

ifosfamide
cisplatin
tenofovir
expired tetracycline

3

reabsoprtive defect in the thick ascending loop
autosomal recessive
presents like loop diuretics

Barrter Syndrome

4

reabsoprtive defect of NaCL in the DCT
similar to affects of thiazides
autosomal recessive
leads to hypokalemia, hypomagnesemia

Gitelman syndrome

5

gain of function mutation that increases sodium reabsorption in the CT presents like hyperaldoseteronism
BUT aldosterone is barley detectable

Liddle SYndrome

6

SIADH has a deficiency in what

11B-hydroxysteroid DH

7

normal function of 11B-hydroxysteroid DH

usually turns cortisol into cortisone which is the inactive mineralocorticoid receptor, so without this enzyme then there is an overstimulation of the mineralocorticoid receptors causing HTN

8

licorice can cause

SIADH , blocks 11B-hydroxysteroid

9

what is interesting about SIADH

there are low aldositeron levels because this is not what is doing the stimulation

10

what cytokines are made by TH1 cells

IL-2 and IFN gamma. leads to stimulation of t cells and macrophages

11

UTI tx

amoxiccilin

12

neonatal infection tx

ampicillin combined with gentamicin

13

syphillis tx

penicillin g

14

pseudomonas tx

pipercillin or tmicracillin

15

describe what is seen in Distal renal Tubular Acidosis ( Type 1)

- hypokalemia
- urine ph > 5.5
- impaired H+ excretion by alpha intercalated cells
- no new HCO3- is generated
-metabolic acidosis

16

what is going on in proximal renal tubular acidosis Type 2

- HCO3- is not reabsorbed back into the body
- metabolic acidosis
- hypokalemia
- urine ph is

17

type 4 - Hyperkalemic Renal Tubular Acidosis ?

- low aldosterone
- impaired ammonium excretion
- urine ph