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Flashcards in 9/29 Deck (89):
1

what cells produce anti mullein hormone

serotli cells

2

what cells produce internal make reproductive organs

leydig cells

3

what stimulates the wollfian duct to turn into male internal genitalia

leydig cell (testosterone)

4

what is responsible for the external male genitalia

dihydrotestosterone

5

ambiguous genitalia in men occurs when

17 alpha hydroxylase deficiency

6

ambiguous genitalia in females occurs when

congenital adrenal hyperplasia ( androgen excess)

7

deficiency in MAC complements C5b-C9b will cause

constant neisseria infections

8

releasing factors recognize what kind of codons?

stop codons

9

what facilitates the release of the polypeptide from the ribosome, stopping protein synthesis

releasing factors

10

charged tRNA does what

delivers the amino acids for protein synthesis

11

prior to fertilizations what stage is the secondary oocyte in

arrested at metaphase of meiosis 2

12

what phase is the primary oocyte arrested in before puberty

prophase of meiosis 1

13

name some antiEGFR drugs

cetuximab and panitumumab

14

what is the first line treatment for bulimia

fluoxetine. nutritional rehabilitation and psychotherapy

15

what amphetamine drug has been used to treat binge eating disorder

lisdexamfetamine

16

what kind of drug is desipramine

TCA

17

use of ACEI and ARBS during pregnancy can cause what in the baby (5)

anuria (failure of kidney to make urine)
oligohydraminos
pulmonary hypoplasia
limb contractures
calvarium problems

18

what kind of drug is methyldopa

alpha 2 agonist

19

pancreatic islet cell tumor called VIPOma can cause what symptoms

large watery diarrhea
hypokalemia and lack of acid production

20

what antibiotic is an agonist to motion and stimulates movement in the stomach and the duodenum

erythromycin

21

someone with korsakoff syndrome who receives thiamine will have a reverse in every symptom except

memory loss

22

CD15 is seen on what cell

Reed Sternburg cells

23

iron absorption in the gut mainly happens where

in the primal jejunum and the duodenum

24

in a Billroth 2 gastrojejunostomy what part of the stomach is removed to decrease acid production

antrum

25

pyridoxine is absorbed where in the bowel

jejunum and ileum

26

st elevation in leads II, III and aVF shows an infarct in what vessel in 90% of people

RCA

27

st elevations in V1-V4 ( anterior septum) would be an infarct in what vessel

LAD

28

ST elevation in V5-V6 is an infarct in what vessel

LCX

29

the posterior inferior wall of the heart is supplied by

the posterior descending branch of the RCA (90% OF PEOPLE)

30

SA NODE RECEIVES blood from the

RCA

31

what is a well known complication of prolactinoma

low bone density

32

in women what happens if hyperprolactinoma is not treated

there will be prolonged hypogonadism that can lead to low levels of estrogen which causes bone loss and vaginal dryness

33

UDE of colchicine

diarrhea and nausea

34

what drug that treats MRSA causes myopathy

daptomysin

35

what is the MOA of daptomysin

depolarizes the cellular membrane by creating transmembrane channels

36

why can you not use daptomyicin to treat pneumonia

because it is inactivated by surfactant

37

3 drugs that treat MRSA

vancomycin
daptomycin
linezolid

38

what is kussmal sign

a rise in JVP during inspiration due to pericarditis even though usually JVP would fall

39

holosytolic murmur at the apex?

mitral regurgitation

40

loud P2 is heard when

pulmonary HTN

41

difficulty climbing stairs and getting up from a chair are classic signs of

polymyositis

42

polymyositis has an increased expression of what

MHC 1 on the sarcolemma causing auto antigens to CD8 cells and causing muscle damage

43

what can improve a praitents with CF condition longterm

pancreatic lipase, helps with the absorption of macronutrients

44

how does sulfalazine and mesalamine work

inhibit cytokine, PG, and leukotriene synthesis and create Crohns disease

45

in granulomatous diseases like sarcoidosis, why is there an increase in calcium

because the macrophages in the granuloma express 1-alpha-hydroxylase which increases serum 1,25DH vitamin D synthesis, leading to increased absorption of calcium from the intestine

46

why is lung infarction rare after emboli

because there is collateral blood supply with bronchial and pulmonary arteries

47

when does intrapulmonary shunting occur

when the lung is getting good perfusion but bad ventilation in an area

48

a child who presents with white pupils, meant retardation and a PDA was exposed to what in utero? how could this be prevented

Rubella
Live Vaccine

49

who should receive the live rubella vaccine

12months-15months
4-6 year olds
non pregnant women who are childbearing age who have no rubella antigen

50

what is enfurvitide

fusion inhibit use in HIV

51

reversible decline in neurological function because the liver is failing to get ride of waste products is called

hepatic encephalopathy

52

what is the treatment for high blood ammonia seen in hepatic encephalopathy

lactulose

53

what amyloidosis is associated with multiple myeloma

AL amyloidosis

54

most common lung cancer in women and non smokers

adenocarcinoma

55

small cell lung carcinoma usually occurs where

in the major bronchi

56

what is the most common cause of DIC (bleeding from incision sights) in a pregnant woman

release of tissue factor (thromboplastin) from injured placenta into the maternal circulation

57

what is acute fatty liver of pregnancy?

micro vesicular fatty infiltrates of hepatocytes which impairs the production of coagulation factors causing DIC

58

what kind of inheritance is sickle cell

AR

59

what is the most common indicator of obesity related restrictive lung disease

decreased ERV

60

immunoglobulin light rain found in urine of people with multiple myeloma

bence jones protein

61

name two dopamine agonist that stimulate the dopamine receptor directly

bromocriptine (ergo compound) and pramiprexole (non ergo compound)

62

selegiline does what

inhibits MAOIB so dopamine won't be broken down

63

what does amantadine do

enhances the endogenous effects of dopamine to alleviate some of the motor symptoms of PD

64

what two COMT inhibitors stop the breakdown of levodopa

entacopone and tolcapon

65

what are the main cells found in sarcodoisis granulomas

CD4

66

what virus is anicteric 80% of the time ?

hep a in children, means there are no clinical symptoms

67

how do ADHD meds work

increase the amount of stimulants ( NE and D) in the prefrontal cortex

68

what is an over intense WBC increase response to bacterial infection or malignancy called

leukemia reaction

69

what granulocytes are greatly increased in CML

basophil
eosinophil
neutrophil

70

normal venous Co2

45

71

normal alveolar co2

40

72

normal venous O2

40

73

normal alveolar O2

104

74

what presents with rose spots on the trunk and abdomen, diarrhea and escalating fever

typhoid fever

75

in regards to collagen what is seen in aging and the formation of wrinkles

decreased collagen fibril production

76

a palpable contender gallbladder , weight loss and obstructive jaundice are signs of what

pancreatic adenocarcinoma blocking the head of the pancreas blocking the common bile duct

77

most important environmental risk factor for pancreatic cancer

smoking

78

what part of the kidney can uric acid precipitate

distal tube and collecting duct because of the low acidic pH of the urine here

79

Abacavir (NRTI) hypersensitivity is strongly associated with what?

HLA-B57:01 allele

80

what horrible side effect can efavirenz and nevi rapine cause

NNRTI drugs that can cause SJS and toxic epidermal necrolysis

81

treatment for restless leg syndrome

dopamine agonist (pramipexole)

82

low concentrations of what have been found in the substantia nigra of patients with RLS?

iron

83

two dopamine receptor antagonist

metoclopromide
prochlorperazine

84

neurokinin 1 antagonist for nausea

aprepitant
fosaprepitant

85

what is the antibiotic of choice to treat lung abscess

clindamycin

86

name the 8 inducers of CYP 450

- St. Johns Wart
- Rifampin
- Phenytoin
- Barbiturates
- Carbamazepine
- Floroquinolones
- Cyclophosphamide
- Modafinil
- Griseflouvin

87

what is the cause of laneway lesions

septic micro emboli in skin vessels from infective endocarditis

88

most common valve affected in infective endocarditis

mitral valve

89

in developed countries what is the most common underlying disease that causes infective endocarditis

mitral valve prolapse