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Flashcards in Biochem Questions Deck (29):
1

which GLUT transporter is located on pancreatic islet cells, hepatocytes, small intestine and kidneys

GLUT2

2

what GLUT transporter is for neuronal glucose transport and the placenta

GLUT 3

3

what is the frustocse GLUT transporter found in sperm and g.i tract

Glut 5

4

what does asterixis mean and what is it seen in

- flapping hand tremor
seen in hepatic encephalopathy

5

in hepatic encephalopathy there are increased levels of what floating around

ammonia, due to the liver not being able to get ride of it

6

name two muscarinic antagonist that can treat organophosphate posing

atropine and pralidoxime

7

how do you treat hartnup disease

administer nicotinic acid, nicotinamide and high protein diet

8

nicotinamide is another name for

niacin

9

what does the enzyme Arginase doe

it turned arginine into ornithine and urea in the urea cycle

10

how to treat arginase deficient?

low protein diet

11

when you block the urea cycle and it leads to the overproduction of carbamyl phosphate what is produced

orotic acid

12

what type of heritage is seen in G6PD D

x-linked

13

what is a drug that is given for UTI that has oxidative properties and can precipitate hemolysis in people with G6PD D

TMP-SMX

14

what is the defected enzyme in Hereditary Orotic Aciduria

UMP Synthase ( uridine 5' monophosphate)

15

UMP synthase dose what

it converted orotic acid into UMP

16

what can bypass the enzymatic affect go UMP synthase defect?

uridine supplementation

17

what is the presentation of Hereditary Orotic Aciduria

- AR disorder
- physical and mental retardation
-megaloblastic anemia
- elevated urinary orotic acid
- high MCV
- low reticulocyte
-low HBg
disorder of de novo synthesis of pyrimidines

18

what is the first fatty acid produces by ACOA in the fed state during lipogenesis

Palmitic Acid

19

when does gluconeogenesis become the major supplier of energy

after 12-18 hours of fasting

20

amanita phalloides is what

death cap mushroom (amatoxin)

21

what do amatoxins do

they go to the liver and bind to DNA dependent RNA polymerase II and block mRNA synthesis causing APOPTOSIS

22

Acyclovir inhibits what

DNA polymerase

23

what is found in the castor oil plant and is a potent toxin the inhibits protein synthesis by cleaving rRNA of 60s subunit

Ricin

24

x-linked sideroblastic anemia s due to what

gamma-aminolevulinate synthase mutation

25

self mutilation, dystonia, choreoasthetosis and hyperuricimea are signs of . x-linked

Lesch-Nyan Syndrome

26

what is deficient in Lesh-Nyhan syndrome

hypxantine-guanine phosphoribosyltransferase (HGPRT)

27

high concentrations of Fructose 2-6 Bis Ph. inhibit what and cause what

inhibit gluconeogensis and cause things like alanine to be used to make glucose

28

what causes the activation of PFK2

insulin

29

name two types os silencing RNA

siRNA (small interfering) and microRNA(miRNA)