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Flashcards in Heme/Onc Deck (189)
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1

name the important neutrophil chemotactic agents

C5a
IL-8
LTB4
kvllikrein
platelet-activating factor

2

lipid A from bacterial LPS binds what on macrophages to induce septic shock

CD 14

3

what causes eosinophilia

Neoplasm
Asthma
Allergic RXN
Chronic adrenal insufficniey
parasites

4

what lymphocyte mediate cell immunity

T cells

5

what lymphocyte mediates humoral immune response

b cells

6

cell wth clock face chromatin distribution and eccentric nucleus with well developed golgi

plasma cell

7

what makes oxidized vitamin k into reduced vitamin k so it can activate the coagulation factors

epoxide reductase

8

antithrombin inhibits wha factors

2
7
9
10
11
12

9

inhibit ADP induced expression of GpIIb/IIIa

Ticlopidine
clopidogrel
Prasugrel

10

inhibit GpIIb/IIIa directly

Abciximab, Eptifibatide, Tirofiban

11

what activates vWF to bind to GpIb

Ristocetin

12

spur cells are seen in

Abetalipoproteinemia and Liver disease

13

what test tests for autoimmune hemolytic anemia because the body produces AB to RBC

direct coombs test

14

a test that detects antibodies to RBC unbound in the patients serum. used in pregnant women and before blood transfusions

indirect coombs test

15

cis deletion of alpha globulin in alpha thalassemia means what

deletions are on the same chromosome

16

cis deletion of A thalamseima is seen in

Asians

17

trans deletion of A thalassemia is seen in

Black people

18

b thalesemia is present in what people

mediteraniean

19

what is protective against major beta thalassemia

HbF until 6 months

20

b thalassemia major patients have an increased chance of what problem

parvovirus B19 induced aplastic crisis

21

what is the chelation for lead poison used in children

Succimer

22

sideroblastic anemia has a defect in what

ALA synthase gene

23

treatment for sideroblastic anemia

ALA synthase or pyridoxine

24

historical test used to diagnose B12 def.

Schilling test ( tells if the problem is malabsorption or dietary insufficiency)

25

defect in UMP synthase that causes failure to thrive in children and megaloblastic anemia. No hyperammonemia is present

Orotic Aciduria

26

important physical symptom of Diamond Blackfan syndrome

triphalangeal thumb

27

haptoglobin are increased in what kind of hemolysis

extravascular hemolysis

28

haptoglobin are decreases in what kind of hemolysis

intravascular hemolysis ( paroxysmal nocturnal hemoglobunbria)

29

hemolytic anemia of the newborn because of decreased levels of ATP is seen because of

Pyruvate kinase deficiency

30

what is the terminal complement inhibitor that treats Paroxysmal Nocturnal Hemoglobinuria

Eculizumab