Antiepileptic Drugs (Potentiators of GABA action)

Question 1

What type of seizures is Clonazepam (Klonopin) used to treat?

Answer 1

Myoclonic and Absence seizures

Question 2

What class of medication is Clonazepam?

Answer 2

Benzodiazepine

Question 3

What condition is Diazepam (Valium) used to treat?

Answer 3

Status epilepticus

Question 4

What class of medication is Diazepam?

Answer 4

Benzodiazepine

Question 5

What type of seizures is Gabapentin (Neurontin) used for?

Answer 5

Partial seizures

Question 6

What additional effect does Gabapentin provide?

Answer 6

Analgesia

Question 7

What is Phenobarbital (Luminal) primarily used for in children?

Answer 7

Epilepsy

Question 8

What is a key mechanism of Phenobarbital?

Answer 8

↑ binding of GABA and ↑ Cl- influx

Question 9

What type of seizures is Tiagabine (Gabitril) used to treat?

Answer 9

Partial seizures

Question 10

What is the mechanism of action of Tiagabine?

Answer 10

Inhibits reuptake of GABA and ↑ CNS level of GABA

Question 11

What is Topiramate commonly known as?

Answer 11

Topamax

Topiramate is the generic name for the brand medication Topamax.

Question 12

What class of medication is Topiramate?

Answer 12

Anticonvulsant

Question 13

What is the mechanism of action of Topiramate?

Answer 13

Na channel blocker

Question 14

How does Topiramate affect GABA levels?

Answer 14

↑GABA level

Question 15

Name Potentiators of GABA action

Answer 15

Clonazepam (Klonopin)
Diazepam (Valium)
Gabapentin (Neurontin)
Phenobarbital (Luminal)
Tiagabine (Gabitril)
Topiramate (Topamax)