NARROW-SPECTRUM (FIRST-GENERATION) CEPHALOSPORINS Flashcards
(16 cards)
What is the generic name for Duricef?
Cefadroxil
Cefadroxil is an antibiotic used to treat bacterial infections.
What is the brand name for the generic drug Cefazolin?
Ancef, Kefzol
Cefazolin is commonly used for surgical prophylaxis and treatment of infections.
What is the generic name for Keflex?
Cephalexin
Cephalexin is used to treat various infections caused by bacteria.
What are first-generation cephalosporins also known as?
Narrow-spectrum cephalosporins
Against which type of bacteria are first-generation cephalosporins primarily effective?
Gram-positive bacteria
Name two Gram-positive bacteria that first-generation cephalosporins are effective against.
- Staphylococcus aureus
- Streptococcus pneumoniae
- Streptococcus pyogenes
What is the Gram-negative coverage of first-generation cephalosporins?
Limited activity
List three Gram-negative bacteria that have some activity against first-generation cephalosporins.
- Escherichia coli
- Klebsiella pneumoniae
- Proteus mirabilis
What are some common uses for first-generation cephalosporins?
- Skin and soft tissue infections (SSTI)
- Respiratory tract infections
- Urinary tract infections (UTI)
- Surgical prophylaxis
Which first-generation cephalosporin is commonly used for surgical prophylaxis?
Cefazolin
What is a commonly prescribed oral agent among first-generation cephalosporins?
Cephalexin
Name another oral option among first-generation cephalosporins.
Cefradine
What is the mechanism of action for first-generation cephalosporins?
Inhibiting bacterial cell wall synthesis
Are first-generation cephalosporins effective against methicillin-resistant Staphylococcus aureus (MRSA)?
No
What are some common side effects of first-generation cephalosporins?
- Nausea
- Vomiting
- Diarrhea
- Allergic reactions
Fill in the blank: First-generation cephalosporins have minimal activity against _______.
Gram-negative bacteria
