DRUGS USED IN DISORDERS OF COAGULATION

Question 1

What is the generic name for ReoPro?

Answer 1

Abciximab

Abciximab is a monoclonal antibody used as an antiplatelet agent.

Question 2

What is the trade name for recombinant tissue plasminogen activator?

Answer 2

Activase*

Alteplase is commonly used to treat ischemic strokes and myocardial infarctions.

Question 3

What is the generic name for the medication known as Amicar?

Answer 3

Aminocaproic acid

Aminocaproic acid is used to reduce bleeding during surgery.

Question 4

What is the trade name for Anisindione?

Answer 4

Miradon

Anisindione is an anticoagulant medication.

Question 5

What is Antihemophilic factor also known as?

Answer 5

Factor VIII

It is crucial for blood clotting and is used in hemophilia treatments.

Question 6

What is the trade name for Thrombate III?

Answer 6

Antithrombin III

Antithrombin III is used to treat patients with hereditary antithrombin deficiency.

Question 7

What is the trade name for Angiomax?

Answer 7

Bivalirudin

Bivalirudin is a direct thrombin inhibitor used in anticoagulation.

Question 8

What is the generic name for Plavix?

Answer 8

Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent blood clots.

Question 9

What type of drug is Fondaparinux?

Answer 9

Anticoagulant

Fondaparinux is a synthetic pentasaccharide that inhibits factor Xa.

Question 10

What is the trade name for Lovenox?

Answer 10

Enoxaparin

Enoxaparin is a low-molecular-weight heparin used for anticoagulation.

Question 11

What is the generic name for Persantine?

Answer 11

Dipyridamole

Dipyridamole is used to prevent thromboembolic complications.

Question 12

What is the mechanism of action for Argatroban?

Answer 12

Direct thrombin inhibitor

Argatroban is primarily used in patients with heparin-induced thrombocytopenia.

Question 13

What is the trade name for Iprivask?

Answer 13

Desirudin

Desirudin is a direct thrombin inhibitor used for prophylaxis of deep vein thrombosis.

Question 14

What is Urokinase used for?

Answer 14

Thrombolytic therapy

Urokinase is used to dissolve blood clots in conditions such as pulmonary embolism.

Question 15

Fill in the blank: The trade name for Tranexamic acid is _______.

Answer 15

Cyklokapron

Tranexamic acid is used to reduce bleeding during surgery and in trauma.

Question 16

True or False: Warfarin is an anticoagulant medication.

Answer 16

True

Warfarin is commonly used for long-term anticoagulation therapy.

Question 17

What is the trade name for Retavase?

Answer 17

Reteplase

Reteplase is a thrombolytic agent used to treat acute myocardial infarction.

Question 18

What is the generic name for Coumadin?

Answer 18

Warfarin

Warfarin is a vitamin K antagonist used for anticoagulation.

Question 19

What is the primary purpose of drugs used in coagulation disorders?

Answer 19

To either prevent blood clots from forming (anticoagulants) or promote blood clotting (prothrombotic agents or antifibrinolytics).

Question 20

What are anticoagulants commonly referred to as?

Answer 20

Blood thinners.

Question 21

How are heparin and related products administered?

Answer 21

Parenterally (e.g., injection).

Question 22

What is the mechanism of action for heparin?

Answer 22

Inhibiting the coagulation cascade.

Question 23

Name an example of a heparin product.

Answer 23

Heparin, enoxaparin, bivalirudin.

Question 24

What are Direct Oral Anticoagulants (DOACs) used for?

Answer 24

To directly inhibit either factor Xa or thrombin.

Question 25

Provide examples of Direct Oral Anticoagulants.

Answer 25

Rivaroxaban, apixaban, dabigatran.

Question 26

What do vitamin K antagonists do?

Answer 26

Inhibit the synthesis of vitamin K-dependent clotting factors.

Question 27

What is a common example of a vitamin K antagonist?

Answer 27

Warfarin (Coumadin).

Question 28

What is the function of antiplatelet agents?

Answer 28

Prevent platelets from sticking together and forming clots.

Question 29

List examples of antiplatelet agents.

Answer 29

Aspirin, clopidogrel, ticagrelor.

Question 30

What are antifibrinolytic drugs used for?

Answer 30

To prevent the breakdown of blood clots (fibrinolysis) and promote clotting.

Question 31

Name two examples of antifibrinolytic drugs.

Answer 31

Tranexamic acid (TXA), epsilon-aminocaproic acid (EACA).

Question 32

What are coagulation factors used for?

Answer 32

To replace missing or deficient clotting factors in conditions like hemophilia.

Question 33

Provide examples of coagulation factors.

Answer 33

Factor VIII (for hemophilia A), Factor IX (for hemophilia B).

Question 34

What does desmopressin (DDAVP) do?

Answer 34

Increases factor VIII and von Willebrand factor.

Question 35

What is the role of ferric subsulate?

Answer 35

A stypic agent used to stop bleeding by causing agglutination of surface proteins.

Question 36

What are reversal agents?

Answer 36

Specific agents to counteract the effects of some anticoagulants.

Question 37

What is a reversal agent for warfarin?

Answer 37

Vitamin K.

Question 38

What is a reversal agent for heparin?

Answer 38

Protamine sulfate.

Question 39

What factors influence the choice of medication for coagulation disorders?

Answer 39

Specific coagulation disorder, severity of bleeding or clotting risk, individual patient factors.

Question 40

Why is monitoring important in anticoagulant therapy?

Answer 40

To monitor the effectiveness of anticoagulant therapy.

Question 41

What regular blood tests are necessary for monitoring warfarin?

Answer 41

INR.

Question 42

What regular blood tests are necessary for monitoring heparin?

Answer 42

aPTT.