Drugs for CHF (β-Adrenergic Agonists)

Question 1

What is Dobutamine (Dobutrex) used for?

Answer 1

Cardiogenic shock

Dobutamine is a medication used in the treatment of cardiogenic shock.

Question 2

What mechanism does Dobutamine activate?

Answer 2

Activates adenylyl cyclase

This activation increases the levels of cAMP in the cell.

Question 3

What effect does Dobutamine have on cAMP levels?

Answer 3

↑ cAMP

Increased cAMP leads to various cardiac effects.

Question 4

What does increased cAMP do to calcium channels?

Answer 4

Phosphorylates Ca channels

This phosphorylation enhances calcium influx, improving cardiac contractility.

Question 5

What is the primary use of Dopamine?

Answer 5

Cardiogenic shock

Dopamine is also utilized in treating cardiogenic shock.

Question 6

What mechanism does Dopamine activate?

Answer 6

Activates adenylyl cyclase

Similar to Dobutamine, it increases cAMP levels.

Question 7

What effect does Dopamine have on cAMP levels?

Answer 7

↑ cAMP

This increase contributes to its positive inotropic effects.

Question 8

What does increased cAMP do to calcium channels when Dopamine is administered?

Answer 8

Phosphorylates Ca channels

This leads to enhanced cardiac contractility and improved heart function.