CARBAPENEMS & MONOBACTAM Flashcards
(18 cards)
What is Aztreonam also known as?
Azactam
Aztreonam is a monobactam antibiotic used to treat infections caused by Gram-negative bacteria.
What is the trade name for Doripenem?
Doribax
Doripenem is a carbapenem antibiotic effective against a broad spectrum of bacteria.
Ertapenem is marketed under which name?
Invanz
Ertapenem is used for treating various infections, including intra-abdominal infections.
What is the combination of Imipenem and cilastatin known as?
Primaxin
Cilastatin is added to imipenem to prevent its breakdown in the kidneys.
What is the brand name for Meropenem?
Merrem IV
Meropenem is another carbapenem antibiotic that is used to treat severe infections.
What are carbapenems?
Carbapenems are broad-spectrum beta-lactam antibiotics effective against a wide range of bacteria, including both gram-positive and gram-negative organisms.
Examples include imipenem, meropenem, and ertapenem.
What are monobactams?
Monobactams, like aztreonam, are a class of beta-lactam antibiotics primarily active against gram-negative aerobic bacteria.
Aztreonam is the main example of monobactams.
What is the spectrum of activity of carbapenems?
Carbapenems have a broad spectrum of activity against a wide range of bacteria.
This includes both gram-positive and gram-negative organisms.
What is the spectrum of activity of monobactams?
Monobactams are primarily focused on gram-negative bacteria.
This includes specific pathogens like Pseudomonas aeruginosa.
How do carbapenems differ structurally from monobactams?
Carbapenems have a more complex structure than monobactams.
Why are carbapenems useful against resistant strains?
Carbapenems are more resistant to degradation by beta-lactamases than older beta-lactams.
What is the mechanism of action of carbapenems?
Carbapenems inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
What are common clinical uses of carbapenems?
Carbapenems are used for severe infections, including those caused by resistant bacteria.
What is the mechanism of action of monobactams?
Monobactams inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
What are common clinical uses of monobactams?
Monobactams are used for gram-negative bacterial infections, particularly those caused by Pseudomonas aeruginosa.
What is a key clinical consideration regarding cross-reactivity?
There is some cross-reactivity between carbapenems and other beta-lactams, particularly penicillins.
How should patients with penicillin allergies be considered regarding carbapenems?
Patients with penicillin allergies should be considered carefully before prescribing carbapenems.
Is aztreonam likely to cause allergic reactions?
Aztreonam is generally considered less likely to cause allergic reactions than other beta-lactams.
