Choloinergic Drugs 1 Flashcards
(28 cards)
What type of agonist is Acetylcholine (Miochol)?
Muscarinic & Nicotinic agonist
Acetylcholine is short-acting.
Inhibitors of Acetylcholine Release
What is the clinical use of Botulinum toxin (Botox)?
Strabismus, wrinkle removal (chemical surgery)
It is a potent toxin.
Inhibitors of Acetylcholinesterase
What is the primary use of Donepezil (Aricept)?
Prevention and management of Alzheimer’s disease
Inhibitors of Acetylcholinesterase
What is Edrophonium (Tensilon) used for?
Diagnosis of Myasthenia gravis
It is short acting (5-10 min).
Inhibitors of Acetylcholinesterase
What is the duration of action for Pyridostigmine (Mestinon)?
Long acting (3-6 hr)
It is used for the treatment of Myasthenia gravis.
Muscarinic Receptor Agonists
What is the primary use of Bethanechol (Urecholine)?
Overcome urinary retention and abdominal distension
Bethanechol is a muscarinic receptor agonist that stimulates bladder contraction.
Muscarinic Receptor Agonists
What condition is Pilocarpine (Isopto) used to treat?
Treatment of Glaucoma
Pilocarpine reduces intraocular pressure by increasing aqueous humor outflow.
Nicotinic Receptor Agonists
What is Nicotine commonly used for?
Smoking cessation programs
Nicotine replacement therapies such as Nicorette and NicoDerm help individuals quit smoking.
Nicotinic Receptor Agonists
What is Succinylcholine used for?
Muscle relaxant (surgery)
Succinylcholine is used to induce muscle relaxation during surgical procedures.
Nicotinic Receptor Agonists
What mechanism does Succinylcholine utilize?
Persistent depolarization
Succinylcholine causes continuous stimulation of the neuromuscular junction, leading to muscle relaxation.
Nicotinic Receptor Agonists
Fill in the blank: Nicotine is found in products like _______.
[Nicorette, NicoDerm]
Nicotinic Receptor Agonists
True or False: Succinylcholine is a muscle relaxant used for pain relief.
False
Succinylcholine is specifically used for muscle relaxation during surgeries, not for pain relief.
Muscarinic Receptor Antagonists
What is the primary use of Atropine (Atropisol)?
Cholinergic toxicity, sinus bradycardia, mydriatic (eye exam)
Atropine is often utilized in emergency situations to counteract cholinergic toxicity.
Muscarinic Receptor Antagonists
Ipratropium (Atrovent) is primarily used as a _______.
[bronchodilator]
Ipratropium is commonly prescribed for asthma patients to help open airways.
Muscarinic Receptor Antagonists
What type of agent is Oxybutynin (Ditropan LX)?
Antispasmotic agent, Cholinergic blocker
Oxybutynin is primarily used to treat overactive bladder symptoms.
Muscarinic Receptor Antagonists
Tolterodine (Detral LA) is used to treat _______.
[urinary urgency]
Tolterodine helps manage symptoms of an overactive bladder.
Nicotinic Receptor Antagonists
What type of drug is Pancuronium?
Muscle relaxant, a competitive ach receptor blocker
Pancuronium is commonly known by its brand name Pavulon.
Nicotinic Receptor Antagonists
What is the mechanism of action for Tubocurarine?
Competitive ach receptor blocker
Tubocurarine is also a muscle relaxant.
Nicotinic Receptor Antagonists
True or False: Tubocurarine is a non-competitive ach receptor blocker.
False
Tubocurarine is a competitive ach receptor blocker.
Nicotinic Receptor Antagonists
Fill in the blank: Pancuronium is a _______.
muscle relaxant, a competitive ach receptor blocker
Nicotinic Receptor Antagonists
What are the two examples of nicotinic receptor antagonists mentioned?
- Pancuronium
- Tubocurarine
Other drugs
What is the primary use of Cisapride (Propulsid)?
GI, antiulcer, anti-GERD, ↑ Ach, binds serotonin receptor
Cisapride is used to treat gastrointestinal disorders by increasing acetylcholine release and binding to serotonin receptors.
Other drugs
What type of receptor does Metoclopramide (Reglan) block?
Dopamine receptor
Metoclopramide is used as an antinauseant and works by blocking dopamine receptors, enhancing gastrointestinal motility.
