Tetracyclines Flashcards
(16 cards)
What are tetracyclines?
A broad-spectrum class of antibiotics used to treat various bacterial infections.
Common examples include tetracycline, doxycycline, and minocycline.
How do tetracyclines work?
By inhibiting bacterial protein synthesis, preventing the growth and spread of bacteria.
They bind to the bacterial 30S ribosomal subunit.
What is the mechanism of action of tetracyclines?
They bind to the bacterial 30S ribosomal subunit, blocking aminoacyl-tRNA transfer to the ribosomal acceptor site.
This inhibits the addition of amino acids to the growing polypeptide chain.
What are the types of tetracyclines?
- Naturally Occurring: Tetracycline, chlortetracycline, oxytetracycline, demeclocycline
- Semi-Synthetic: Lymecycline, methacycline, minocycline, rolitetracycline, doxycycline
- Glycylcycline: Tigecycline
- Newer Tetracyclines: Eravacycline, sarecycline, omadacycline
These classifications are based on their origin and chemical modifications.
What are common uses of tetracyclines?
- Rickettsial infections
- Ehrlichiosis
- Anaplasmosis
- Leptospirosis
- Chlamydial infections
- Pelvic inflammatory disease
- Syphilis
- Traveler’s diarrhea
They can also treat infections caused by specific bacteria like Staphylococcus aureus, including MRSA.
True or False: Tetracyclines can be used to treat acne.
True
They are also used for early Lyme disease.
What age group is generally not recommended to use tetracyclines?
Children under 8 years of age.
Tetracyclines can cause teeth discoloration in children and adults.
What are important considerations when taking tetracyclines?
- Risk of teeth discoloration
- Potential liver toxicity and steatosis
- Interference with absorption by certain food and dairy products
Tetracyclines should be taken one hour before or two hours after meals.
Fill in the blank: Tetracyclines are primarily used to treat _______.
bacterial infections.
What specific types of infections can tetracyclines treat?
- Pneumonia
- Respiratory tract infections
- Skin infections
- Eye infections
- Lymphatic infections
- Intestinal infections
- Genital infections
- Urinary infections
These infections can vary based on the specific bacteria involved.
What is Demeclocycline also known as?
Declomycin
Demeclocycline is a tetracycline antibiotic used to treat various infections.
What is the common name for Doxycycline?
Vibramycin
Doxycycline is a broad-spectrum antibiotic used in various infections.
What is the concentration of Doxycycline suspension?
50 mg/5 mL syrup
This formulation is commonly used for pediatric patients.
What is Minocycline also known as?
Minocin
Minocycline is a tetracycline antibiotic often used for skin infections.
What is Tetracycline classified as?
Generic antibiotic
Tetracycline is one of the earliest antibiotics discovered.
What is the brand name for Tigecycline?
Tygacil
Tigecycline is used to treat complicated skin and intra-abdominal infections.
