PROTEIN SYNTHESIS INHIBITORS

Question 1

What is the generic name for Chloromycetin?

Answer 1

Chloramphenicol

Chloramphenicol is an antibiotic used to treat bacterial infections.

Question 2

What does chloramphenicol inhibit?

Answer 2

Microbial protein synthesis

Chloramphenicol specifically targets protein synthesis in bacteria.

Question 3

Which subunit of the ribosome does chloramphenicol bind to?

Answer 3

50 S subunit of the 70 S ribosome

The 70 S ribosome is found in prokaryotes.

Question 4

What action does chloramphenicol inhibit?

Answer 4

Action of peptidyl transferase

Peptidyl transferase is crucial for peptide bond formation.

Question 5

What does the inhibition of peptidyl transferase prevent?

Answer 5

Peptide bond formation

This is essential for protein synthesis.

Question 6

Chloramphenicol prevents the binding of which molecule to the peptidyl transferase active site?

Answer 6

Aminoacyl transfer RNA

This binding is necessary for adding amino acids to the growing peptide chain.

Question 7

What is the mechanism of action of chloramphenicol?

Answer 7

Chloramphenicol stops bacterial growth by binding to the bacterial ribosome and inhibiting protein synthesis

It blocks peptidyl transferase.

Question 8

What property of chloramphenicol allows it to diffuse through the bacterial cell membrane?

Answer 8

Chloramphenicol is lipid-soluble

This lipid solubility facilitates its penetration into bacterial cells.

Question 9

What is chloramphenicol used for?

Answer 9

Chloramphenicol is used in the treatment of infections caused by bacteria.

Question 10

How does chloramphenicol work?

Answer 10

It works by killing bacteria or preventing their growth.

Question 11

In what situations is chloramphenicol typically used?

Answer 11

It is used to treat serious infections in different parts of the body.

Question 12

Can chloramphenicol be used with other antibiotics?

Answer 12

Yes, it is sometimes given with other antibiotics.

Question 13

Should chloramphenicol be used for colds or flu?

Answer 13

No, it should not be used for colds, flu, or other virus infections.

Question 14

What types of infections should chloramphenicol be used for?

Answer 14

It should only be used for serious infections in which other medicines do not work.

Question 15

What are some serious side effects of chloramphenicol?

Answer 15

It may cause blood problems and eye problems.

Question 16

What are symptoms of blood problems caused by chloramphenicol?

Answer 16

Symptoms include pale skin, sore throat, fever, unusual bleeding or bruising, and unusual tiredness or weakness.

Question 17

True or False: Chloramphenicol is safe for all types of infections.

Answer 17

False

Question 18

Fill in the blank: Chloramphenicol should only be used for _______ infections.

Answer 18

serious

Question 19

What should you inform your healthcare professional about when taking this medicine?

Answer 19

If you are taking any of the specified medicines

It is crucial to disclose all medications to avoid harmful interactions.

Question 20

Which vaccines should usually not be used with this medicine?

Answer 20

Cholera Vaccine, Live

Live vaccines can interact negatively with certain medications.

Question 21

Name two medications that may require dose adjustments if used together.

Answer 21

• Fosphenytoin
• Phenytoin

These medications may have significant interactions with the primary medicine.

Question 22

What is a potential risk when using this medicine with Ceftazidime?

Answer 22

Increased risk of certain side effects

Both drugs may be necessary for treatment despite the risks.

Question 23

Fill in the blank: Using _______ or tobacco with certain medicines may cause interactions.

Answer 23

alcohol

Alcohol can affect how medications work and increase side effects.

Question 24

What other medical problems should be disclosed to the doctor when taking this medicine?

Answer 24

• Anemia, bleeding, or other blood problems
• Liver disease

These conditions may increase the risk of side effects.

Question 25

True or False: It is safe to use this medicine with any food.

Answer 25

False ## Footnote Certain medicines should not be used at or around the time of eating.

Question 26

Which medication may cause blood problems when used with Chloramphenicol?

Answer 26

Chloramphenicol ## Footnote Chloramphenicol itself is known for its potential to cause blood issues.

Question 27

List three medications that may require careful monitoring when prescribed together with this medicine.

Answer 27

* Tacrolimus * Voriconazole * Rifampin ## Footnote These medications can have significant interactions and may need dose adjustments.

Question 28

What action may a doctor take if two medicines are prescribed that interact?

Answer 28

Change the dose or frequency of use ## Footnote Adjustments may be necessary to minimize risks.

Question 29

Fill in the blank: Patients with _______ may have an increased risk of side effects from this medicine.

Answer 29

liver disease ## Footnote Liver function can significantly influence drug metabolism and effects.

Question 30

What is the recommended way to take Chloramphenicol?

Answer 30

With a full glass (8 ounces) of water on an empty stomach (1 hour before or 2 hours after meals) ## Footnote Unless otherwise directed by your doctor.

Question 31

What should be used to measure the oral liquid form of Chloramphenicol?

Answer 31

A specially marked measuring spoon or other device ## Footnote The average household teaspoon may not hold the right amount of liquid.

Question 32

Why is it important to complete the full course of Chloramphenicol treatment?

Answer 32

To help clear up your infection completely ## Footnote Even if you begin to feel better after a few days.

Question 33

What factors determine the dose of Chloramphenicol?

Answer 33

Strength of the medicine, number of doses per day, time allowed between doses, length of treatment ## Footnote Depends on the medical problem for which you are using the medicine.

Question 34

What is the usual dose of Chloramphenicol for adults and teenagers with bacterial infections?

Answer 34

12.5 mg per kg (5.7 mg per pound) of body weight every six hours ## Footnote Dose is based on body weight.

Question 35

What is the usual dose of Chloramphenicol for infants up to 2 weeks of age?

Answer 35

6.25 mg per kg (2.8 mg per pound) of body weight every six hours ## Footnote Dose is based on body weight.

Question 36

What is the usual dose of Chloramphenicol for infants 2 weeks of age and older?

Answer 36

12.5 mg per kg (5.7 mg per pound) every six hours or 25 mg per kg (11.4 mg per pound) every twelve hours ## Footnote Dose is based on body weight.

Question 37

What should you do if you miss a dose of Chloramphenicol?

Answer 37

Take it as soon as possible, or skip it if it's almost time for the next dose ## Footnote Do not double doses.

Question 38

True or False: You should change your dose of Chloramphenicol without consulting your doctor.

Answer 38

False ## Footnote Follow your doctor's orders or the directions on the label.