Drugs to manage Parkinson’s disease Flashcards
(9 cards)
Dopamine Precursors
What is Levodopa?
A precursor to dopamine used in the treatment of Parkinson’s disease
Levodopa is converted to dopamine in the brain.
Dopamine Precursors
What is the brand name of Levodopa?
Larodopa
Larodopa is a common brand name for Levodopa.
Dopamine Precursors
What condition is Levodopa primarily used to treat?
Parkinson’s disease
Parkinson’s disease is a neurodegenerative disorder characterized by motor symptoms.
Dopamine Precursors
Levodopa is used in combination with which other medication?
Carbidopa
Carbidopa helps prevent the conversion of Levodopa to dopamine before it reaches the brain.
Dopamine Precursors
True or False: Levodopa is effective on its own without any other medications.
False
Levodopa is often used in combination with carbidopa to enhance its effectiveness.
Inhibitors of Levodopa or Dopamine Metabolism
What is the role of Carbidopa (Lodosyn) in the treatment of Parkinson’s disease?
Does not enter CNS, ↓ peripheral Dopa decarboxylase & dopamine, ↓ side effects
Carbidopa is used to enhance the effectiveness of Levodopa by preventing its conversion to dopamine before it reaches the brain.
Inhibitors of Levodopa or Dopamine Metabolism
What is the mechanism of action of Selegiline (Deprenyl)?
↓ MAO-B, ↑ CNS dopamine level
Selegiline is used as a second-line treatment for Parkinson’s disease to increase dopamine levels in the central nervous system.
Inhibitors of Levodopa or Dopamine Metabolism
True or False: Carbidopa enters the central nervous system (CNS).
False
Carbidopa is designed to work peripherally and does not penetrate the CNS.
Inhibitors of Levodopa or Dopamine Metabolism
Fill in the blank: Selegiline is indicated for _______ disease as a second line treatment.
[Parkinson’s]
Selegiline is specifically used in the context of Parkinson’s disease management.
