Tricyclics Flashcards
(20 cards)
What is the generic name for Elavil?
Amitriptyline
Used for depression and prosthetic-neuralgia (off label)
What is Amoxapine used to treat?
Depression
It is a generic medication.
Clomipramine is labeled for which disorder?
Obsessive-compulsive disorder (OCD)
It is marketed under the brand name Anafranil.
What is the brand name for Desipramine?
Norpramin
Used for depression and prosthetic-neuralgia.
What is the generic name for Sinequan?
Doxepin
A tricyclic antidepressant.
What is the generic name for Tofranil?
Imipramine
A tricyclic antidepressant.
Protriptyline is marketed under which brand name?
Vivactil
A tricyclic antidepressant.
What is the brand name for Trimipramine?
Surmontil
A tricyclic antidepressant.
What are tricyclic antidepressants (TCAs)?
A class of older antidepressants that inhibit the reuptake of serotonin and norepinephrine in the brain
What is the primary mechanism of action for TCAs?
Blocking the reuptake of serotonin and norepinephrine
What neurotransmitters do TCAs increase in the brain?
Serotonin and norepinephrine
Why are TCAs not typically the first choice for treating depression?
Due to potential for more side effects and availability of newer, safer antidepressants
List three commonly used TCAs.
- Amitriptyline (Elavil)
- Imipramine (Tofranil)
- Nortriptyline (Pamelor)
What are some potential side effects of TCAs?
- Dry mouth
- Blurred vision
- Constipation
- Drowsiness
What risks are associated with TCAs compared to newer antidepressants?
- Higher risk of anticholinergic effects
- Higher risk of antihistaminergic effects
- Higher risk of cardiotoxic effects
True or False: TCAs can increase the risk of suicidal thoughts and behaviors.
True
In what situations might TCAs be recommended?
- When other antidepressants are ineffective or not tolerated
- For depression resistant to other treatments
- To treat certain anxiety disorders
- To treat chronic nerve pain
What should be done if discontinuing TCAs?
Gradually reduce the dose to prevent withdrawal symptoms
What conditions warrant caution when prescribing TCAs?
- History of seizures
- Narrow-angle glaucoma
- Other heart conditions
Why is close monitoring by a healthcare professional essential when using TCAs?
Especially when starting treatment or increasing the dosage
