Anxiolytics and Hypnotic Drugs 1 (Barbiturates)

Question 1

Barbiturates

What is Butabarbital (Butisol) classified as?

Answer 1

Sedative-hypnotic

Increases binding of GABA and chloride influx.

Question 2

Barbiturates

What are the uses of Phenobarbital (Luminal)?

Answer 2

Insomnia, sedation, epilepsy

Increases binding of GABA and chloride influx, with an action duration of approximately 5 hours.

Question 3

Barbiturates

What is the action duration of Thiopental (Pentothal)?

Answer 3

Approximately 10 minutes

Used for anesthesia induction and increases binding of GABA and chloride influx.

Question 4

Barbiturates

Fill in the blank: Phenobarbital increases _______ of GABA.

Answer 4

binding

It also increases chloride influx.

Question 5

Barbiturates

True or False: Butabarbital (Butisol) has a longer action duration than Thiopental (Pentothal).

Answer 5

False

Thiopental has an action duration of approximately 10 minutes, while Phenobarbital has ~5 hours.

Question 6

Barbiturates

What mechanism do Butabarbital, Phenobarbital, and Thiopental share?

Answer 6

↑ binding of GABA, ↑ Cl- influx

All three drugs enhance the effect of GABA, leading to increased chloride ion influx.

Question 7

Name: 3 Barbiturates

Answer 7

Butabarbital (Butisol)
Phenobarbital (Luminal)
Thiopental (Pentothal)