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Flashcards in antimicrobial chemotherapy - anti fungal drugs Deck (23):
1

What can fungus be subdivided into

Yeats and filamentous fungi (moulds)

2

What is the combined form of fungus called

dimorphic fungi

3

What are the different classes of anti fungal drugs

Polyenes
Azoles
Allyamines
Echinocandins

4

How do polyenes increase the permeability of the cell wall

Bind to ergosterol in fungi cell wall

5

What is the reason for polyenes toxicity

also bind to other sterols (cholesterol) in mammalian cells

6

What are two examples of polyenes anti fungal drugs

amphotericin B
Nystatin

7

Is amphotericin toxic?

yes

8

What polyenes anti fungal drug can be available for IV use

amphotericin B

9

How is nystatin available

topic use (creams, oral, pessaries)

10

How do azoles work as an anti fungal

inhibit ergosterol synthesis

11

How are azoles subdivided

Imidazoles
triazoles

12

Name two imidazoles

miconazole
ketoconazole

13

Give three examples of triazoles

flucanozole
itraconazole
voriconazole

14

How is flucaozole given and what is it active against

used for oral and parenteral treatment of yeast infections

15

What is itraconazole active against

Yeast and filamentous fungi

16

What can treat aspergillosis

voriconazole and itraconazole

17

What is building a resistance to fluconazole

resistance among some candida species

18

How do allylamines work as anti fungals

suppress ergosterol synthesis

19

what is an example of an allylamine anti fungal

terbinafine

20

What is terabinafine primarily active against and its clinical use

dermatophytes
dermatophyte infections of the skin and nails e.g. athletes foot

21

How does echinocandins work as an anti fungal

inhibit the synthesis of glucan polysaccharide

22

What are the three echinocandins

caspofungin
mycafungin
andiulafungin

23

What are ecinocandins used for

serious aspergillus and candida infections