B8 W3 Flashcards

1
Q

White, fibrous capsule on testes

A

Tunica albuginea

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2
Q

Tunica vaginalis

A

Layer of serous membrane covering the testis derived from peritoneum.

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3
Q

Cells that for inner epithelia of seminiferous tubules

A

Sertoli cells

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4
Q

Where does spermatogenesis occur within seminiferous tubule?

A

Gaps between sertoli cells

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4
Q

Where does spermatogenesis occur within seminiferous tubule?

A

Gaps between sertoli cells

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5
Q

What prevents passage of spermatoza into blood?

A

Junctions between sertoli cells

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6
Q

Sustencular cells

A

Cells which support gamete devElopment

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7
Q

Male sustencular cells

A

Sertoli cells

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8
Q

Female sustencular cells

A

Granulosa cells

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9
Q

Phases of spermatogenesis

A

Mitotic proliferation, meoitic proliferation, cytodifferentation

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10
Q

Produced at the end of mitotic proliferation of spermatogenesis

A

Resting primary spermatocytes

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11
Q

Resting primary spermatocytes

A

Cells which breach the tight junctions of sertoli cells and move into luminal compartments

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12
Q

Produced at the end of meiosis

A

Spermatid

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13
Q

Production of secondary spermatocyte

A

Meiosis- two divisions. First division has genetic shuffling to produce secondary spermatocyte. Second division to generate four haploid spermatid

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14
Q

Cytodifferentiation

A

Cytoplasmic bridges break open and release spermatids into seminiferous tubule

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15
Q

Number of clones of spermatids from 1 A1 spermatogonium

A

25

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16
Q

Final stage of spermatogenesis

A

Spermiogenesis. Golgi apparatus migrates to the poles and forms vesicle. Formation of streamlined spermatozoa

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17
Q

What forms the acrosome?

A

Occurs during spermiogenesis by action of golgi apparatus giving rise to glycoprotein rich granules which coalesce

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18
Q

What forms the flagella of sperm?

A

Centrioles

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19
Q

Interval cycle in spermatogenesis

A

16 days

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20
Q

What initates germ cell development?

A

Specification of primordial germ cells in endoderm

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21
Q

Where do primordial germ cells colonise?

A

The gonadal ridge

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22
Q

Origin of sertoli cells

A

Coelomic epithelia in medulla

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23
Q

Roles of testis

A

Spermatogenesis and hormone production

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24
What forms the blood testis barrier?
Tight junctions between Sertoli cells
25
What blood-testis barrier?
Testosterone produced by Leydig cells
26
Epididymis
Long, coiled duct where sperm mature, are concentrated and testore. Develops from collecting tubules of the mesonephros
27
Structures where the epididymis develops
Collecting tubules of mesonephros
28
First Site of steroidogenesis
Mitochondria- conversion of cholesterol into pregnenolone
29
Main site of steroidogenesis
Smooth endoplasmic reticulum
30
How is testosterone converted to 5-alpha-dihydrotestosterone?
By reductase enzyme
31
How is testosterone converted into oestradiol?
Aromatase enzyme
32
What carries testosterone to the seminiferous tubules?
Blood
33
What carries testosterone to accessory sex glands?
Lymph
34
Seminal vesicle
Site of fructose, vitamin C, prostaglandins and ph semen
35
Prostate
Secretes ions to maintain osmotic balance-also priduces prostate specific antugen and citric acid
36
How much semen is produced by the prostate?
20-30%
37
Drugs for treating prostate cancer
GnRH antagonists
38
Finasteride
Reductase inhibitor
39
Bicalutamide
Androgen receptor antagonist
40
Oligozoospermia
Low sperm count
41
Asthenozoospermia
Low sperm motility
42
Teratospermia
Abnormal sperm morphology
43
Temperature that testis work
35 degree
44
Cycle of erection
Flaccid, tumescence, erection, detumescence, flaccid
45
What cleaves cGMP to GMP?
Phosphodiesterase 5
46
Alprostadil
Vasodilator which agonises prostaglandin E1 to treat erectile dysfunction
47
Apomorphine
Dopamine receptor for erectile dysfunction via indirectly relaxatioin of smooth muscle
48
Where are Leydig cells in testis?
interstital tissues of testis
49
What hormones control sertoli cells?
Tesotsterone and FSH
50
Morbidly obese BMI
40+
51
Prevalence of overweight
Men greater than women
52
Prevalence of obesity
Women is greater than men
53
Doubly Labelled water method
Collecting samples of urine and saliva to measure disappearance of isotopes and measure energy output
54
Redundancy
Neural and molecular signals with strong "drive to eat"
55
Effect on melanocortin stimulating hormone on appetite
Suppresses appetite by acting on hypothalamus receptors. Effect is enhanced by leptin.
56
Peptide YY
Satiety hormone released from intestines
57
Glucagon like peptide 1
Satiety hormone released from intestines
58
External factors influencing appetite
Convenience of food, price, availability, mood
59
What regions of the hypothalamus respond to appetite?
Acruate and ventromedial nuclei- responds to leptin, insulin, ghrelin and gluose
60
Paraventricular nuclei
region of the hypothalamus mediates autonomic and neuroendocrine responses for energy homeostasis?
61
Tractus solitarius
Region of hindbrain for short-term control of satiety- peptide YY, cholecystokinin and GLP-1