Physiology and Pharmacology of the Liver Flashcards Preview

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Flashcards in Physiology and Pharmacology of the Liver Deck (64)
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1

Describe the blood supply to the liver

Dual supply in and single supply out

2

What are all hepatocytes in contact with?

Blood from both the hepatic portal vein and the hepatic artery

3

Where does arterial and venous blood mix

In the liver sinusoids

4

What shape is a cross section of each lobule

Hexagonal

5

What is found in the centre of each lobule

a branch of the hepatic vein (central vein)

6

What is found in each of the 6 corners of each lobule

A triad (portal triad)

7

What is in each portal triad

A branch of the hepatic portal vein
A branch of the hepatic artery and
A bile duct

8

What is arranged as hepatic plates?

Cords of hepatocytes

9

Blood flows inwardly through what to the central vein

Sinusoids

10

Bile secreted by hepatocytes flows outwardly through what to the bile duct

Canaliculi

11

What are hepatocytes arranged in between

Sinusoids in plates two cells thick

12

What does the basolateral membrane face

The space of Disse

13

What is the space of Disse

An extracellular gap between the pericellular space and the endothelial cells that line the fenestrated sinusoids

14

What forms the canaliculi

The apical membrane of adjacent hepatocytes

15

Sinusoidla spaces contain which 3 types of cells

Endothelial cells
Kuppfer cells
Stellate (lto) cells

16

What do endothelial cells allow the movement of?

Solutes but not cells

17

What type of cells remove particulate matter (bacteria)

Kuppfer cellls

18

Where do the Stellate cells lie and what is their role?

Within the space of Disse
Important for the storage of vitamin A and may play a role in fibrosis and cirrhosis in liver injury

19

Describe the sequence of the intraheaptic bile system

Canaliculi
Terminal bile ductules
Perilobar ducts
Interlobar ducts
Septal ducts
Lobar ducts
2 hepatic ducts
The common hepatic duct

20

How much bile is produced per day

0.6-1.2 litres per day

21

Where is bile between meals

Stored and concentrated in the gall bladder - the sphincter of Oddi is closed

22

What happens to bile during a meal

Chyme in the duodenum stimulates gall bladder smooth muscle to contract and bile spurts into the duodenum via the cystic and common bile ducts

23

What is the role of bile

It participates in the digestion and absorption of fats

24

During meals, what is the ionic composition of bile similar to

Plasma

25

Why does the flow rate of bile increase during meals

In response to secretin released from duodenal S cells

26

What does the slightly alkaline pH of bile contribute to?

Micelle formation
Neutralization of chyme
pH adjustment for digestive enzyme action
Protection of the mucosa

27

What do hepatocytes secrete and where?

Primary juice in the canaliculi which drain in the the biliary ductules

28

What is hepatic bile composed of

Primary bile acids mainly cholic and chenodeoxycholic acids
Water and electrolytes
Lipids and phospholipids
Cholesterol
IgA
Bilirubin

29

What is bilirubin a product of

The porphyrin component of haemoglobin

30

Is the total amount of bile salts in the body smaller or larger than the total amount of bile salts emptied into the duodenum during digestive activity

Much smaller

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