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Flashcards in Biochemical aspects of liver metabolism Deck (54)
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1

Where is bile produced?

Liver

2

Name a plasma protein which is secreted in the liver

Albumin

3

What important molecules are stored in the liver?

Fuels, Iron, Vitamins

4

By what 2 processes are unwanted molecules eliminated?

Metabolism
Excretion into the biliary tree and faecal excretion

5

What is the importance of carbohydrate and lipid metabolism

Fuel storage

6

What is the importance of the amino acid metabolism

Urea cycle

7

What is electrophoresis

It allows the separation of proteins by size

8

Name 5 functions of plasma proteins

Maintenance of oncotic or colloid osmotic pressure
Transport of hydrophobic substancces
pH bufferring
Enzymatic
Immunity

9

What is the purpose of maintaining osmotic pressure

Prevents the loss of plasma proteins

10

Name some hydrophobic substances transported by plasma proteins

Steroid hormones
Free fatty acids
bilirubin
cholesterol

11

Name an ezymatic function of plasma proteins

Blood clotting

12

What are the 2 main substances secreted through plasma protein secretion

Albumin and alpha globulins

13

What do alpha globulins do?

Transport lipoproteins, lipids, hormones and bilirubin

14

What does retinol binding protein do?

Transports vitamin A

15

Name the main two beta globulins

Transferrin and fibrinogen

16

What is the function of Transferrin

Transports Fe3+
Indicator or iron deficiency

17

What is the function of fibrinogen

Inactive for of fibrin
Involved in the clotting of blood

18

What is Albumin and what is its main roll

Most abundant plasma protein
Small, negatively charge, water soluble protein
It is the main determinant of plasma oncotic pressure

19

How much albumin does the liver synthesise per day

14g

20

What stimulates the synthesis of albumin

Insulin

21

What causes low levels of albumin

Liver disease
Starvation / low protein diet

22

What is iron? How is it transported? and how is it stored?

It is a component of haemoglobin, myoglobin and cytochromes
Transported as ferric ion Fe3+ bound to transferrin
Stored in cells bound to ferritin

23

How is copper transported in the blood

Bound to ceruloplasmin

24

What is the roll of copper

Essential for regulation of redox reactions, transport and use of iron

25

What is the disease called where there is a copper deficiency

Wilson's disease

26

What 2 groups of hormones are hydrophobic

Steroid hormones
T3/T4 thyroid hormones

27

How are hormones transported

In the circulation bound to specific transport molecules

28

What is thyroxine bound to?

Thyroid-binding globulin
What is cortisol bound to

29

What is cortisol bound to

Cortisol binding globulin

30

What is the purpose of hormone transport

They extend biological half life and increase plasma concentration

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