Pathology of the Stomach Flashcards Preview

Gastro > Pathology of the Stomach > Flashcards

Flashcards in Pathology of the Stomach Deck (20):
1

What are the 2 main types of inflammatory disorders of the stomach

Acute Gastritis and Chronic Gastritis

2

What are the 3 main types of chronic gastritis

Autoimmune (rare)
Bacterial (H pylori)
Chemical

3

What is autoimmune chronic gastritis caused by

Anti-parietal and anti-intrinsic factor antibodies are present = B12 deficiency

4

What can happen to the spinal cord in autoimmune chronic gastritis

Demyelination of the spinal cord

5

What is autoimmune chronic gastritis

A pre-malignant condition

6

What is the most common type of chronic gastritis and what happens with it?

H. Pylori - pathogenetic
Causes damage to the epithelium and other aspects of the wall

7

What does H pylori increase the risk for

Duodenal ulcer
Gastric ulcer
Gastric carcinoma
Gastric lymphoma

8

What is the cause of chemical gastritis

Due to NSAIDs, alcohol, bile reflux

9

What might chemical gastritis produce

Erosions or ulcers

10

What is a peptic ulceration

Peptic ulceration is a breach in the GI mucosa as a result of acid and pepsin attack

11

How can you heal an ulcer

Switch off the acid production in the stomach

12

Where can chronic peptic ulcers be found?

Duodenum (very common)
Stomach
Oesophago-gastric junction
Stomal ulcers (very rare)

13

What are important in terms of chronic peptic ulcers

Increased acid production and failure of mucosal defence

14

Describe the appearance of peptic ulcers

Layered
Floor of necrotic fibinopurulent debris
Base of inflamed Granulation tissue
Deepest layer is fibrotic scar tissue

15

What are 5 complications of peptic ulcers

Perforation
Penetration
Haemorrhage
Stenosis
Intractable pain

16

What are the 2 types of gastric tumours

Benign (polyps) and malignant (tumours)

17

What are the 2 branches of malignant gastric tumours

Carcinoma and Lymphoma

18

Describe the epidemiology of gastric adenocarcinomas

High incidence in Asia (genetic factors?)
Decline in the western world
Diet is thought to have a major effect

19

What is the difference in prognosis between intestinal and diffuse

Better prognosis for intestinal

20

Where can gastric adenocarcinoma spread

Local - other organs in the peritoneal cavity and ovaries
Lymph nodes - anywhere in the body
Haematogenous - to the liver through the portal vein

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