BL- Cohan 1 Flashcards Preview

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Flashcards in BL- Cohan 1 Deck (39):
0

Th1 job

Delayed hypersensitivity
Attracts m1 macrophages
Release ifn gama

1

Th17

Makes interleukin 17, IL 17.
Causes very bad inflammation for toughest agents

Pro inflammatory

2

Th2

Helper T cell
Longer development than th1

Brings m2 macrophages (less angry than m1)
Can encourage fibrous capsule growth

3

Th2 fx and cytokine

Scarring
Attracts eosinophils
IL4

4

Tfh

Interacts with developing B cells to "switch"

5

Treg function

Helper cell

Tells all other helper cells to stop responding and making cytokines

"Wiser older sibling"

6

CTL name

Killer cell

Cytotoxic t lymphocyte

7

CD8 mhc class

Cd8 interacts with class one mhc

8

CD4 MHC Class

Cd4 interact with class two MHC

9

CD4 Is on what kind of cell

T helper

10

CD8 are on what cell

CTL

11

MHC Class two chains

Two chains, both bind. Alpha and beta

12

Class one MHC is on...

Every nucleated cell has class one MHC on their surface

13

CTL can see ____ cells

CTL can see All Cells. CTL sees class one MHC, and MHC is on all cells.

14

CLASS TWO MHC
Basics

T helper cells see class two.
Three cells make class two

Dendritic
Macrophage
B Cells

15

Professional Antigen Presenting Cells

Dendritic
Macrophages
B cells

Class two MHC cells

16

B Cell MHC reaction with Tfh

Antigen binds
B cell chops it up
Presents peptide on MHC 2
Tfh interacts
Tfh activates B cell

17

T Independent antigen

Usually carbs
Activates B cell with out T cell
B cell can only make IgM like this

18

HLA D cells

MHC Class 2 cells

Dendritic, macrophage, B cell

19

Hemosiderin

is most commonly found in macrophages and is especially abundant in situations following hemorrhage

21

Ankylosing spondylitis

Strong genetic inflammation activists with IL1

chronic inflammatory disease of the axial skeleton

involves CD8 T cells, which interact with HLA-B.

22

Natural, active immunity

usual immunity that results from real-life exposure to a pathogen.

23

Natural, passive immunity

fetus gets IgG
passively across the placenta from its mother

the baby gets IgA in mother’s milk if she nurses it

24

Artificial, active immunity

: immunity resulting from intentional immunization with vaccines, toxoids, or
other antigenic preparations.

25

Artificial, passive immunity

the use of immune serum or purified antibodies to protect a patient at risk
from a particular disease

26

tetanus, immunization offers close to _____ protection

100%

27

Cause of sherocytosis

Spleen notices membrane defect and pinches some off

28

Glucose-6-phosphate dehydrogenase deficiency

enzyme involved in the pentose phosphate pathway that is especially important in the red blood cell.

genetic condition that predisposes to hemolysis

29

Natural Killer cell activity is enhanced by

IL-2

30

C3b

opsonization

31

C3a, C5a

anaphylaxis

32

C5a

Neutriphil chemotaxis

33

C5b

Cytolysis by Mac

34

First antibody responder?

IgM

35

Second Antibody responder

IgG

36

Best compliment activator of the antibodies?

IgM

37

C1q complement needs to bind how many FCs

2 to activate

38

Coombs Test

detects antibodies that are already attached to red blood cells

39

Indirect Coombs Tets

detect very low concentrations of antibodies present in a patient's plasma/serum prior to a blood transfusion.