First Aid Immunity Flashcards Preview

BL/DD USMLE and Basics > First Aid Immunity > Flashcards

Flashcards in First Aid Immunity Deck (26):
1

Innate Immunity

Receptors recognize germ line encoded pathogens

Fast non specific response

Neutrophils
Macrophages
Dendritic Cells
Natural Killer cells
Complement

2

Adaptive immunity

V(D)J recombination
slow response
Faster with memory

T cell
B cells
Circulating Antibody

3

NK Cells

induce apoptosis of virally infected cells

4

B cell Function

Make antibodies

Opsonize bacteria
Neutralize Viruses
Activate compliment
Sensitize mast cells

5

B cell fx/ IgM, IgG

Activate compliment

6

B cell fx/ IgG

opsonize bacteria, neutralize viruses

7

B cell fx/ IgE

sensitize mast cells

8

T cell Fx

CD4 + T cells help B cell make antibody and produce cytokines

9

FAB

antigen binding fragment
Determines Idiotype

10

Fc

Constant Antibody region

11

Antibody diversity

Random VJ (light)or VJD recombo
Addition of nucleotides during recombo

12


IgG characteristics

Main antibody
Most abundant
Crosses Placenta

13


IgG Functions

Delayed (2) response
*opsonizes bacteria
*neutralizes bacterial Toxins

14


IgA

Prevents attachment of bacteria and virus to mucous membrane
Found in secretions

15

IgM

Immediate (1) response
Fixes complement
Pentamer shape

16

IgD

Unclear fx

17

IgE

binds mast cells and basophiles
allergens cause Cross links
Immediate response through mediator release (Histamine)

18

Classic Pathway

IgG or IgM mediated
(GM makes classic cars)
Antigen-antibody complexes

19

Immune response
C3b fx

C3b Binds Bacteria

20

Immune response
C3a, C5a

anaphylaxis

21

Live attenuated vaccine

Cellular response
Pro: strong immunity
Con: may become virulent

22

Inactivated Vaccine

Humoral Immunity
Pro: stable and safer
Con: weaker response, booster shots needed

23

IgG half life

3 weeks

24

Th1 cytokine

Interferon gama
IFN gama

25

Interferon gama function

Chemotaxis for monocytes

Attracts MANY macrophages/monocytes

Made by Th1

26

M1 macrophages

Macrophages attracted be Th1