DD- Antiviral Drug Action Flashcards Preview

BL/DD USMLE and Basics > DD- Antiviral Drug Action > Flashcards

Flashcards in DD- Antiviral Drug Action Deck (10):
1

Inhibition of neuraminidase (NA) activity in influenza A and B

NA activity necessary to untether virions for egress – if blocked, virions clump at cell surface. Dec viral infectivity

Inhibition of NA impairs viral penetration through mucin secretions. dec infection of other respiratory epithelial cells

Oseltamivir - Zanamivir

2

Prophylaxis and treatment of influenza A infections – limited current use due to resistance

Amantadine - Rimantadine

3

Nausea-vomiting and abdominal pain can occur (5-10%); decreased if taken with food

Headache, fatigue, and diarrhea also reported

Pregnancy category C

Oseltamivir
Adverse Reactions

4

_______may cause insomnia, concentration difficulty, lightheadedness / dizziness, headache

Amantadine

5

______better tolerated - poor CNS penetration

Rimantadine

6

______ diffuses into cell where it is triphosphorylated by intracellular kinases

Acyclovir

7

Long chain saturated alcohol that inhibits replication of many lipid-enveloped viruses (including HSV)

Physiochemically prevents fusion between cellular and viral envelope membranes blocking viral entry into cell

Docosanol (abreva)

8

incorporated into replicating viral DNA strands-->slowing then ceasing DNA elongation

Ganciclovir - Valganciclovir

9

Purine nucleoside analog - inhibits wide variety of DNA and RNA viruses - mechanism not completely understood

also may increase viral mutagenesis rates, ultimately leading to viral suicide

Ribavirin

10

Indicated for RSV immunoprophylaxis in infants and young children with congenital heart disease

Palivizumab