BL- OSTEOARTHRITIS Flashcards Preview

BL/DD USMLE and Basics > BL- OSTEOARTHRITIS > Flashcards

Flashcards in BL- OSTEOARTHRITIS Deck (27):
1

Osteoarthritis

destruction of articular cartilage
proliferation of contiguous bone

2

Degenerative joint disease

a name for OA

3

degenerative arthritis

a name for OA

4

degenerative arthrosis

is a normal degenerative condition associated with aging. It affects mainly
cartilage which becomes rugged, irregular and worn out.

5

Osteoarthrosis

another name for OA

6

Osteoarthritis Symptoms

Joint pain/inflammation
decreased joint mobility
bony spurs

7

Symptoms of OA

pain with use, improved with rest
stiffness
rarely before 40
lack of systematic symptoms

8

Signs of OA

joint tenderness
bony enlargement
crepitance
swelling

9

Heberden's and Bouchard's nodes

Bony enlargement in the inter-phalangeal joint (distal and proximal, respectively)

10

OA deformities

Heberden's and Bouchard's nodes
Genu Varus
Squaring of the 1st carpometacarpal joint
Hallux valgus
c/l spine spondylosis

11

Genu Varus

bow-legged

12

Hallux Valgus

big toe bunnion

13

spondylosis

Degenerative change

14

In all OA studies, the relationship to_______is striking.

aging

15

Which population has the most severe OA disease

Women. Aging is biggest risk factor

16

Primary OA

no known inciting event

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Secondary OA

known event or disease caused the OA

18

The joint in OA is grossly characterized by:

cartilage irregularities and "fissuring"
hypertrophy of bone adjacent to the joint

19

Cartiallage consists of:

Collagen
Proteoglycans
Matrix Proteins
Chrondrocytes
Water

20

Chondrocytes

synthesize extracellualr components

21

Adipokines

cytokine produced by adipose tissue
low grade inflamation
Increases OA risk with obesity

22

Predisposing factors to OA

genetics
metabolic abnormalities
trama
inflammatory joint disease
Obesity
Age

23

Blood tests for OA

aggrecan, keratin sulfate, and chondroitin sulfate; type II collagen, link protein, and osteocalcin; cartilage matrix glycoprotein, and cartilage oligomeric protein (COMP).

COMP appears the most promising.

24

OA treatment

metalloproteinase inhibitors, synthetic proteoglycans, and intra-articular injection of chelators to inhibit MMP.

25

OA Xray would show

Asymmetric loss of cartilage - Bone touching bone
Bony spurs- prolifferative bone
Subchondral sclerosis

26

Matrix metalloproteinases (MMPs)

collectively cleave most if not all of the constituents of the extracellular matrix.

27

Chondrocytes:

synthesize all of the important extracellular components
Proteoglycan
Collagen