BL- Introduction to Hemostasis Flashcards Preview

BL/DD USMLE and Basics > BL- Introduction to Hemostasis > Flashcards

Flashcards in BL- Introduction to Hemostasis Deck (48):
1

Pro teases of the clotting path way are

Prekallikrein
12
11
9
7
10
2
13*

*=not serine

2

Factor X is at _____

the cross roads

3

Factor XIII-
A transglutaminase: forms amide bonds between specific lysine and glutamine residues of fibrin to make a stable____

clot

4

Cofactors of the clotting path way are

HMWK
TF
VIII
V

These speed up the reaction

5

Prekallikrein
12
11
9
7
10
2
13
These are all

Proteases

6

Lack intrinsic enzymatic activity
Act as receptors for other components of enzyme complexes, to speed reactions several hundred to several thousand-fold

Cofactors

7

Fibrinogen of the clotting path way are

Factor I (Fibrin)
*makes the actual clot

8

HMWK
TF
VIII
V
are?

Cofactors

9

_______requires the interaction of platelets, coagulation and fibrinolytic factors, endothelium, proinflammatory and anti-inflammatory mediators, and leukocytes

Hemostasis

10

Clot formation is typically initiated by vascular injury, in which a platelet plug forms and is reinforced with ______ produced via the extrinsic pathway

fibrin

11

Coagulation Factors 1

I Fibrinogen

12

Cofactors

Lack intrinsic enzymatic activity
Act as receptors for other components of enzyme complexes, to speed reactions several hundred to several thousand-fold

13

Coagulation Factors 2

II Prothrombin

14

Coagulation Factors 3

III Thromboplastin

15

Coagulation Factors 5

Proaccelerin

16

Coagulation Factors 7

Proconvertin

17

Coagulation Factors 8

Antihemophilic

18

Coagulation Factors 9

Christmas

19

Coagulation Factors 11

Plasma thromboplastin antecedent

20

Coagulation Factors 13

Fibrin stabilizing

21

Coagulation Factors IV

Calcium

22


Prothrombin + Thromboplastin + Calcium = Thrombin

Fibrinogen + Thrombin = Fibrin

Two-step process of coagulation:

23

The Prothrombin time

measures of prothrombin ratio (PR) and international normalized ratio (INR) are measures of the extrinsic pathway of coagulation. This test is also called "ProTime INR"

24

Almost all blood factors are made in the:

liver

If this isn't functioning well, you become coagulopathic

25

blood factors NOT made by the liver

Tissue factor
Factor VIII
Von Willebrand factor

26

Two-step process of coagulation:

Prothrombin + Thromboplastin + Calcium = Thrombin

Fibrinogen + Thrombin = Fibrin

27

Biliary obstruction leads to vitamin K deficiency due to

fat malabsorption

28

Vitamin K eventually isolated as the factor needed to ______ the bleeding problem

prevent

“K” for “Koagulation”

29

Vitamin K dependent factors

Factor IX
Factor VII
Factor X
Factor II (Thrombin)
Protein C, Protein S

30

Reasons newborns are prone to develop Hemorrhagic disease of the newborn

Vitamin K deficiency

~Decreased stores
~Low levels in breast milk
~Developing gut flora

31

Vitamin K required for _________ of several coagulation proteins in the liver

post translational modification

32

PT test is useful for

Coagulopathy associated with jaundice
Hemorrhagic disease of the newborn

33

Factor IX
Factor VII
Factor X
Factor II (Thrombin)
Protein C, Protein S
these are all?


Vitamin K dependent factors
Factors II, VII, IX, X, Protein C, Protein S

34

Coagulopathy associated with jaundice
Hemorrhagic disease of the newborn

PT test useful

35

The Activated Partial Thromboplastin time (APTT)

activated partial thromboplastin time
characterizes blood coagulation.

PTT is a performance indicator of the efficacy of both the "intrinsic" (now referred to as the contact activation pathway) and the common coagulation pathways.

It is used in conjunction with the prothrombin time (PT) which measures the extrinsic pathway

36

Vitamin K dependent factors are located?

Centrally in the pathway (around 10)

37

PT is a problem in ______ pts

hemophiliac patients

38

hemophiliac patients are deficient in

factor 13 (a) or 9 (b)

39

Vitamin K dependent factors

Factors II, VII, IX, X, Protein C, Protein S

40

Use of the _____led to discovery of the intrinsic pathway factors

APTT

41

Deficiency of __________ not associated with bleeding

Prekallikrein
Factor XII
HMWK

42

Coagulation occurs in three phases

Initiation
Amplification
Propagation

43

Abnormal factors in the _____ pathway will lead to an abnormal ATPP

intrinsic

44

Initiation steps (1)

Tissue Factor exposed

Factor 7a binds TF

Binds Factor 10 (extrinic tenase)-->10a

Factor 9 can also be activated

45

extrinic tenase activates

factors 9 and 10

46

Initiation steps (2)

10a binds-->5a binds-->factor 2

OR

10a binds --> 2

2 leads to 2a leads to amplification

47

2 leads to 2a leads to:

amplification

48

Thrombin (2) activates

Factor 11* important

and
Factor XIa
VIIIa
Va