DD- Virology of RSV Flashcards Preview

BL/DD USMLE and Basics > DD- Virology of RSV > Flashcards

Flashcards in DD- Virology of RSV Deck (24):
1

RSV

Human respiratory syncytial virus (RSV)

2

RSV

a virus that causes respiratory tract infections. It is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood.

3

RSV Epidemiology

Large particle droplet spread
Very high (40-60%) attack rate children < 2 years
Most serious illness in very young, specific high-risk populations

4

is there an rsv vaccine?

no

5

RSV structure- ________ family

paramyxoviridae

6

RSV structure genome

Single-stranded, nonsegmented RNA virus

7

RSV
Fusion of viral envelope to host cell
Fusion of membranes of infected cells to each other “syncytia”

F protein

8

RSV
Initial binding of virus to host cell

G protein:

9

RSV subtypes

A and B
A causes most disease

10

RSV Pathophysiology- Invades:

conjunctiva/nasopharynx

11

RSV causes severe damage to the epithelium and _________apparatus

bronchiolar ciliary

*Results in collection of fluid in the bronchioles and alveoli

12

RSV Pathophysiology _________incubation period

3-5 day

13

Clinical Picture or RSV

Respiratory distress, wheeze/rhonchi, hypoxia, copious secretions: Bronchiolitis

14

RSV causes severe damage to the _________and bronchiolar ciliary apparatus

epithelium

*Results in collection of fluid in the bronchioles and alveoli

15

Testing for RSV

Cell culture – takes more time

Direct antigen detection (rapid test) – not very sensitive/accurate

Nucleic acid/Genomic amplification (PCR) – most accurate and quick in many
places

16

do people get recurrent infections of RSV?

Yes

17

RSV _______ like influenza to avoid immune system

“drifts”

18

RSV has been associated with _________later in life, but whether it causes it is unclear

wheezing & asthma

19

Is there an RSV vaccine?

no

vaccine attempts made disease worse

20

RSV vaccine recipients were not protected against disease and they had worse RSV disease when they got infected with RSV.

Hypothesized that serum antibody without local respiratory antibody may _________disease.

worsen

21

RSV immunoprophylaxis with Palivizumab (Respigam)

Respigam is a human pooled antibody with high RSV titers, shown to have decrease in disease severity and hospitalization

22

A mouse monoclonal anti-RSV antibody was developed

Palavisumab
(Synagis)

23

RSV vaccine recipients were not protected against disease and they had _____RSV disease when they got infected with RSV.

Hypothesized that serum antibody without local respiratory antibody may _________disease.

worse
worsen

24

Antibody/immune protection is _________for infection, but previous infection may prevent more severe disease

incomplete