DD- VIRAL PATHOGENS Flashcards Preview

BL/DD USMLE and Basics > DD- VIRAL PATHOGENS > Flashcards

Flashcards in DD- VIRAL PATHOGENS Deck (23):
1

Tropism

a given virus is likely to infect certain tissues and not others. Enterotropic viruses replicate in the gut and neurotropic viruses in nervous system tissue.

2

A virus acute infection is characterized by a _______and the production of a large number of progeny.

high viral replication rate

3

A _________ lasts for longer periods of time and may be the result of an acute primary infection that is not cleared, and the ability of the virus to be transmitted to other organisms or offspring of the host is maintained.

persistent infection

4

usually infections of epithelial cells at body surface, such as gut, respiratory tract, eyes.

Often have short incubation times and include viruses which include many serotypes (rapidly mutating)
and result in short-lived immunity, primarily via secretory IgA. Re-infections are common.

Acute local

Examples include colds and diarrheal disease.

5

Usually primary infection is also in epithelium, but viremia and systemic infection result in secondary replication at various sites, result in lifelong immunity and include both secretory IgA and serum IgG.

Acute systemic

Examples include measles and smallpox.

6

Ongoing virus infection and/or replication, usually with mild or inapparent disease in a healthy host. Manifestation of disease is often coincident with immune suppression or other complications.

Chronic viral infection

7

usually refers to virus infections that continue to produce new virus over a long period of time.

Chronic viral infection, Persistent

8

refers to virus infection in which the virus genome is relatively silent, there is little gene transcription in most infected cells, and there is little to no disease in a healthy host for a long time, in many cases for life

Latent Chronic viral infection

9

no symptoms on initial infection, long incubation period, may or may not induce an immune response, and eventual disease is followed by progressive deterioration and death.

Slow Chronic viral infection

10

Latent virus differs from dead-end infections (those caused by defective virus or which lack the ability to ever produce virus) in that they retain the ability to re-initiate transcription and replication to produce new virus. This process is referred to as:

reactivation or recrudescence.

11

VZV in nerves

Latent viral infection

12

Rubella in neonate

Chronic viral infection

13

Smallpox, measles

Acute Systemic viral infection

14

Colds, diarrhea

Acute Local viral infection

15

AIDS, cancer is a _____ virus

slow, progressive

16

Epithelia, monocytes, lymphocytes, others

CMV

17

Neuron latency (ganglia) viruses

Varicella Zoster virus (VSV)
Herpes simplex-2 (HSV-2)
Herpes simplex-1 (HSV-1)

18

Contact or respiratory route viruses

Varicella Zoster virus (VSV)

19

Close contact usually sexual transmission

Herpes simplex-2 (HSV-2)

20

Epstein-Barr Virus (EBV) transmission mode

Saliva

21

Orofacial lesions and (some)
Genital lesions
Encephalitis
Herpes whitlow
Herpes keratitis
Neonatal herpes

Herpes simplex-1 (HSV-1)

22

Genital lesions and (some)
Orofacial lesions
Encephalitis
Herpes whitlow
Herpes keratitis
Neonatal herpes

Herpes simplex-2 (HSV-2)

23

Infectious mononucleosis,
Burkitt's lymphoma;
In immunocompromised
patients: central nervous system
lymphoma

Epstein-Barr Virus (EBV)