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BL/DD USMLE and Basics > DD-Inflammatory Skin Disorders > Flashcards

DD-Inflammatory Skin Disorders Flashcards

(66 cards)

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1
Q

to refer to spongiotic dermatitis, s nonspecific reaction pattern seen on skin biopsy

A

Dermatitis

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2
Q

Common skin disease which may begin at any age, however a majority begin before age 5.
Prevalence: 7-17.2% in children

A

Atopic Dermatitis

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3
Q

Atopic Dermatitis

Diagnostic Criteria

A

Itchy skin +Plus 3 OF:

History of involvement of skin creases (or face if pt < 10 yrs)

Personal history of asthma or hay fever (or FH of atopic disease if pt < 4 yrs)

History of dry skin within the last year

Visible flexural eczema (or face if pt < 4 yrs)

Onset under 2 years of age

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4
Q

The _____ mutation is asc. w/ Atopic Dermatitis leading to worsened Staphlyococcus aureus as a superantigen

A

Filaggrin

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5
Q

Atopic Dermatitis Infantile (Birth – 2 years)

Eruption is characterized by:

A

erythematous papules
redness
scaling and areas of lichenification

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6
Q

Xerosis means

A

Dry Skin

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7
Q

Number one skin disease globally

A

eczema

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8
Q

A general term that describes inflammation of the skin

A

Dermatitis

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9
Q

Non-immunologically mediated reaction resulting from a direct cytotoxic effect. Can be first exposure or many. No test for this

A

Irritant Contact Dermatitis

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10
Q

Allergic Contact Dermatitis Requires contact exposure of an allergen, immune response and development of _______

A

“memory” T cells

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11
Q

What is contact allergy?

A

Delayed type hypersensitivity reaction

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12
Q

Requires contact exposure of an allergen, immune response and development of “memory” T cells

A

Allergic Contact Dermatitis

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13
Q

Allergic Contact Dermatitis tends to be

A

itchy

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14
Q

Allergic Contact Dermatitis effects

A

the epidermis

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15
Q

Cellulitis affects the

A

dermis

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16
Q

Cellulitis feels

A

painful

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17
Q

Langerhans cells present allergen to

A

T cells

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18
Q

Elicitation of ACD caused by inflammatory cytokines including TNFa and_____.

A

IL-1

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19
Q

Contact dermatitis is determined by

A

patch testing

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20
Q

__________ present allergen to T cells

A

Langerhans cells

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21
Q

Elicitation of ACD caused by inflammatory cytokines including ______ and IL-1.

A

TNFa

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22
Q

When do you patch test?

A 
Patients with suggestive history
Patients with resistant dermatitis
Chronic dermatitis
Occupationally related dermatitis
Atopic eczema - flaring
Stasis dermatitis
Photo or airborne distribution
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23
Q

Top Contact Allergen

A

Nickel

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24
Q

Female
Younger age
12.9% nickel positivity in Denver children < 5 yr
30.4% nickel positivity (UCH Age < 18 years)
Ear piercing
14.8% with ears pierced: 1.8% without

A

Risk Factors for Nickel sensitivity

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25
Unscented products may have a masking fragrance, therefore patients with fragrance allergy should use only _________ products.
fragrance-free
26
``` Patients with suggestive history Patients with resistant dermatitis Chronic dermatitis Occupationally related dermatitis Atopic eczema - flaring Stasis dermatitis Photo or airborne distribution these are all? ```
reasons to do a patch test
27
Risk Factors for Nickel sensitivity
Female Younger age 12.9% nickel positivity in Denver children < 5 yr 30.4% nickel positivity (UCH Age < 18 years) Ear piercing 14.8% with ears pierced: 1.8% without
28
Nickel sensitivity is ____ in the US and ______ in Europe
raising in the US and declining in Europe | Europe regulates nickel
29
Quaternium-15
most frequently causes ACD in the United States. | It is a fragrance
30
Bacitracin and Neomycin are in _____
neosporin | causing ACD- delayed hyper sensitivity
31
Drug Eruptions are another type of
acd delayed hyper sensitivity
32
Usually begins 7-14 days after starting a new medication | Starts sooner in cases of receiving an “old” medication (i.e. inadvertent re-challenge)
Drug Eruptions acd delayed hyper sensitivity
33
Exanthematous Eruptions/drug rashes are usually ____ in kids and ____ in adults
virus in kids and meds in adults
34
Often also called 'drug rash' or 'maculopapular eruption' by non-dermatologists, this is the most common form of cutaneous drug eruption
Exanthematous Eruptions
35
Stasis Dermatitis is always on
the lower legs
36
Often seen in association with other signs of venous insufficiency of the lower extremities
Stasis Dermatitis
37
Thick, scaly plaques with “lichenification” that result from chronic rubbing and scratching Topical steroids are first line therapy Antihistamines can be used for itching Patients need to be counseled to break the itch-scratch cycle
Lichen Simplex Chronicus
38
Common in patients with a history of leg swelling, varicose veins or a history of blood clots Primarily found on the medial lower leg just above the ankle Red in color with yellow fibrinous base Borders irregularly shaped They may be purulent if infected
Venous Stasis Ulcers
39
Most often occurs on legs, but can appear on arms and trunk More common in men age 50+ often from over use of soap Also called Discoid Eczema
Nummular Dermatitis
40
Stasis Dermatitis will present with
itching
41
Cellulitis is usually not ____ and will spread
bilateral
42
Round patches may be red, scaly and become crusty Tends to be stubborn Moisturization, minimize soap and topical corticosteroids are first line therapy
Nummular Dermatitis
43
Cellulitis has
pain swelling increasing warmth
44
Seborrheic Dermatitis in neomates
Flaky, white to yellowish oily scale on scalp | Can become confluent with a thick scale covering most of the scalp
45
Facial involvement is usually symmetric over the medial eyebrows, nasolabial folds and ears Occurs in areas rich in sebaceous glands (scalp, face, ears, chest). Characterized by flaky, “greasy” scales
Seborrheic Dermatitis in adults
46
Seborrheic Dermatitis occures in areas rich in
sebicious glands | occurs near hair
47
Seborrheic dermatitis is thought to be due to a combination of an over production of skin oil and irritation from a _____ called Malassezia furfur.
yeast
48
Chronic Plaque Disease Guttate Erythroderma Pustular Psoriasis
Psoriasis | Clinical Subtypes
49
Psoriasis has a thick ____ scale
silvery
50
A condition in which skin cells build up and form scales and itchy, dry patches. Takes a gentic predisposition and environmental trigger
Psoriasis
51
Psoriasis | Clinical Subtypes
Chronic Plaque Disease Guttate Erythroderma Pustular Psoriasis
52
Persistent low grade inflammation favors the development of insulin resistance, obesity and metabolic syndrome
Psoriasis and Comorbidities Metabolic syndrome patients have accelerated atherosclerosis due to inflammation
53
Psoriasis and Comorbidities
cardiovascular disease obesity mi
54
Psoriasis is treated with
anti inflammatory ir immunosuppresents
55
**Stasis derm occurs on
lower legs
56
**Seborrheic dermatitis occurs on
scalp
57
**Atopic dermatitis occurs on
Flexor surfaces
58
**Psoriasis affects
Extensor surfaces, may include arthritis
59
Stasis dermatitis**
– lower extremity edema
60
Seborrheic dermatitis Etiology**
– Malassezia furfur
61
Atopic dermatitis Etiology**
– Filaggrin
62
Irritant dermatitis Etiology**
– Common irritants
63
Allergic contact dermatitis Etiology**
– Common allergens
64
Associated with Asthma and Allergic rhinitis**
Atopic dermatitis
65
Delayed type hypersensitivity reaction (Type IV); Diagnosis confirmed with patch testing**
Allergic contact dermatitis
66
May be associated with increased risk of cardiovascular disease**
Psoriasis

BL/DD USMLE and Basics (55 decks)

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