DD-Inflammatory Skin Disorders Flashcards Preview

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Flashcards in DD-Inflammatory Skin Disorders Deck (66):
1

to refer to spongiotic dermatitis, s nonspecific reaction pattern seen on skin biopsy

Dermatitis

2

Common skin disease which may begin at any age, however a majority begin before age 5.
Prevalence: 7-17.2% in children

Atopic Dermatitis

3

Atopic Dermatitis
Diagnostic Criteria

Itchy skin +Plus 3 OF:

History of involvement of skin creases (or face if pt < 10 yrs)

Personal history of asthma or hay fever (or FH of atopic disease if pt < 4 yrs)

History of dry skin within the last year

Visible flexural eczema (or face if pt < 4 yrs)

Onset under 2 years of age

4

The _____ mutation is asc. w/ Atopic Dermatitis leading to worsened Staphlyococcus aureus as a superantigen

Filaggrin

5

Atopic Dermatitis Infantile (Birth – 2 years)

Eruption is characterized by:

erythematous papules
redness
scaling and areas of lichenification

6

Xerosis means

Dry Skin

7

Number one skin disease globally

eczema

8

A general term that describes inflammation of the skin

Dermatitis

9

Non-immunologically mediated reaction resulting from a direct cytotoxic effect. Can be first exposure or many. No test for this

Irritant Contact Dermatitis

10

Allergic Contact Dermatitis Requires contact exposure of an allergen, immune response and development of _______

“memory” T cells

11

What is contact allergy?

Delayed type hypersensitivity reaction

12

Requires contact exposure of an allergen, immune response and development of “memory” T cells

Allergic Contact Dermatitis

13

Allergic Contact Dermatitis tends to be

itchy

14

Allergic Contact Dermatitis effects

the epidermis

15

Cellulitis affects the

dermis

16

Cellulitis feels

painful

17

Langerhans cells present allergen to

T cells

18

Elicitation of ACD caused by inflammatory cytokines including TNFa and_____.

IL-1

19

Contact dermatitis is determined by

patch testing

20

__________ present allergen to T cells

Langerhans cells

21

Elicitation of ACD caused by inflammatory cytokines including ______ and IL-1.

TNFa

22

When do you patch test?

Patients with suggestive history
Patients with resistant dermatitis
Chronic dermatitis
Occupationally related dermatitis
Atopic eczema - flaring
Stasis dermatitis
Photo or airborne distribution

23

Top Contact Allergen

Nickel

24

Female
Younger age
12.9% nickel positivity in Denver children < 5 yr
30.4% nickel positivity (UCH Age < 18 years)
Ear piercing
14.8% with ears pierced: 1.8% without

Risk Factors for Nickel sensitivity

25

Unscented products may have a masking fragrance, therefore patients with fragrance allergy should use only _________ products.

fragrance-free

26

Patients with suggestive history
Patients with resistant dermatitis
Chronic dermatitis
Occupationally related dermatitis
Atopic eczema - flaring
Stasis dermatitis
Photo or airborne distribution
these are all?

reasons to do a patch test

27

Risk Factors for Nickel sensitivity

Female
Younger age
12.9% nickel positivity in Denver children < 5 yr
30.4% nickel positivity (UCH Age < 18 years)
Ear piercing
14.8% with ears pierced: 1.8% without

28

Nickel sensitivity is ____ in the US and ______ in Europe

raising in the US and declining in Europe

(Europe regulates nickel)

29

Quaternium-15

most frequently causes ACD in the United States.
It is a fragrance

30

Bacitracin and Neomycin are in _____

neosporin
causing ACD- delayed hyper sensitivity

31

Drug Eruptions are another type of

acd delayed hyper sensitivity

32

Usually begins 7-14 days after starting a new medication
Starts sooner in cases of receiving an “old” medication (i.e. inadvertent re-challenge)

Drug Eruptions acd delayed hyper sensitivity

33

Exanthematous Eruptions/drug rashes are usually ____ in kids and ____ in adults

virus in kids and meds in adults

34

Often also called 'drug rash' or 'maculopapular eruption' by non-dermatologists, this is the most common form of cutaneous drug eruption

Exanthematous Eruptions

35

Stasis Dermatitis is always on

the lower legs

36

Often seen in association with other signs of venous insufficiency of the lower extremities

Stasis Dermatitis

37

Thick, scaly plaques with “lichenification” that result from chronic rubbing and scratching

Topical steroids are first line therapy

Antihistamines can be used for itching

Patients need to be counseled to break the itch-scratch cycle

Lichen Simplex Chronicus

38

Common in patients with a history of leg swelling, varicose veins or a history of blood clots

Primarily found on the medial lower leg just above the ankle

Red in color with yellow fibrinous base

Borders irregularly shaped

They may be purulent if infected

Venous Stasis Ulcers

39


Most often occurs on legs, but can appear on arms and trunk
More common in men age 50+
often from over use of soap
Also called Discoid Eczema

Nummular Dermatitis

40

Stasis Dermatitis will present with

itching

41

Cellulitis is usually not ____ and will spread

bilateral

42

Round patches may be red, scaly and become crusty
Tends to be stubborn
Moisturization, minimize soap and topical corticosteroids are first line therapy

Nummular Dermatitis

43

Cellulitis has

pain
swelling
increasing warmth

44

Seborrheic Dermatitis in neomates

Flaky, white to yellowish oily scale on scalp
Can become confluent with a thick scale covering most of the scalp

45

Facial involvement is usually symmetric over the medial eyebrows, nasolabial folds and ears
Occurs in areas rich in sebaceous glands (scalp, face, ears, chest).
Characterized by flaky, “greasy” scales

Seborrheic Dermatitis in adults

46

Seborrheic Dermatitis occures in areas rich in

sebicious glands
(occurs near hair)

47

Seborrheic dermatitis is thought to be due to a combination of an over production of skin oil and irritation from a _____ called Malassezia furfur.

yeast

48

Chronic Plaque Disease
Guttate
Erythroderma
Pustular Psoriasis

Psoriasis
Clinical Subtypes

49

Psoriasis has a thick ____ scale

silvery

50

A condition in which skin cells build up and form scales and itchy, dry patches. Takes a gentic predisposition and environmental trigger

Psoriasis

51

Psoriasis
Clinical Subtypes

Chronic Plaque Disease
Guttate
Erythroderma
Pustular Psoriasis

52

Persistent low grade inflammation favors the development of insulin resistance, obesity and metabolic syndrome

Psoriasis and Comorbidities

Metabolic syndrome patients have accelerated atherosclerosis due to inflammation

53

Psoriasis and Comorbidities

cardiovascular disease

obesity

mi

54

Psoriasis is treated with

anti inflammatory ir immunosuppresents

55

**Stasis derm occurs on

lower legs

56

**Seborrheic dermatitis occurs on

scalp

57

**Atopic dermatitis occurs on

Flexor surfaces

58

**Psoriasis affects

Extensor surfaces, may include arthritis

59

Stasis dermatitis**

– lower extremity edema

60


Seborrheic dermatitis Etiology**

– Malassezia furfur

61


Atopic dermatitis Etiology**

– Filaggrin

62


Irritant dermatitis Etiology**

– Common irritants

63


Allergic contact dermatitis Etiology**

– Common allergens

64

Associated with Asthma and Allergic rhinitis**

Atopic dermatitis

65

Delayed type hypersensitivity reaction (Type IV); Diagnosis confirmed with patch testing**

Allergic contact dermatitis

66

May be associated with increased risk of cardiovascular disease**

Psoriasis