BL- VASCULITIS Flashcards Preview

BL/DD USMLE and Basics > BL- VASCULITIS > Flashcards

Flashcards in BL- VASCULITIS Deck (32):
1

Rheumatoid arthritis (RA) begins with inflammation in which structure/tissue?

Synovium

2

Clinical presentations of this type of vasculitis include temporal headache, jaw claudication, scalp tenderness, and vision loss

Giant cell arteritis

3

Typical histology of small vessel vasculitis:

Leukocytoclastic vasculitis

4

Cytoplasmic –ANCA (c-ANCA) is common to Wegener’s granulomatosis as perinuclear-ANCA (p-ANCA) is common to:

microscopic polyangiitis (MPA)

5

examples of immune complex (IC)-induced vasculitis

Hepatitis B-associated vasculitis

Cryoglobulinemic vasculitis

Henoch-Schönlein purpura

Hypersensitivity vasculitis (cutaneous leukocytoclastic angiitis)

6

suspected immunopathogenic mechanisms that mediate vasculitis

Infection of endothelial cells

Immune complexes (IC)

T cell dependent mediated endothelial cell injury

Autoantibodies such as ANCAs and antiendothelial antibodies

Immune complexes (IC)

7

Vasculitides are a rare group of disorders defined by the size of the vessel involved, the pathologic change in the vessel wall, and the:

clinical presentation

8

In primary vasculitis, the inciting agent is unknown. The vasculitic response may be due to IC deposition, autoantibodies (anti-endothelial, ANCAs), antigen-driven inflammation, and/or infection of: ______

endothelial cells

9

heterogeneous group of clinical disorders characterized by inflammation of blood vessels

vasculitides

10

Vasculitides can be primary or ____ to infectious disorders, drug hypersensitivity, connective tissue diseases, cryoglobulins, and malignancies.

secondary

11

Large-vessel vasculitis

Giant cell arteritis
Takayasu’s arteritis

12

Medium-vessel vasculitis

Polyarteritis nodosa
Kawasaki’s disease

13

Small-vessel vasculitis
(ANCA) positive vasculitides:

Granulomatosis with polyangiitis (Wegener’s)
Eosinophilic granulomatosis with polyangiitis
Microscopic polyangiitis (MPA

14

Small-vessel vasculitis
(ANCA) negative vasculitides:

Essential cryoglobulinemic vasculitis
Cutaneous leukocytoclastic angiitis
Henoch-Schönlein Purpura (HSP):

15

vasculitis Labs

anemia of inflammatory disease
thrombocytosis
low albumin
elevated sed rate/crp
polyclonal gammopathy

16

aortic arch and its branches, can involve any part of the aorta; claudication of upper > lower extremities, CNS events; granulomatous panarteritis

Takayasu’s arteritis

17

temporal arteries
vessels originating from the aortic arch

headache, jaw claudication, scalp tenderness, visual loss;

Giant cell arteritis

18

small/medium arteries; may affect any organ, but skin, joints, peripheral nerves, gut, and kidney are most commonly involved;
necrotizing arteritis
involvement at the vessel bifurcation

***Polyarteritis nodosa

19

Wegener’s Granulomatosis

systemic disorder that involves both granulomatosis and polyangiitis. It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs.

20

***Cytoplasmic –ANCA (c-ANCA) is common to Wegener’s granulomatosis as perinuclear-ANCA (p-ANCA) is common to ______ (MPA)****

microscopic polyangiitis

21

**C-ANCA often binds to

proteinase 3 (PR3) found in the primary granules of neutrophils

22

**P-ANCA often binds to

myeloperoxidase (MPO) found in primary granules of neutrophils

23

plasmapheresis______ beneficial in ANCA-positive vasculitides

IS

24

AFTER treatment of vasculitis high risk of

Atherosclerosis

25

Hepatitis B virus infection is associated with ______

Polyarteritis nodosa**

26

Complement decreases in disorders with circulating ______

Immune Complexes

27

_____are antibodies to antigens found in the cytoplasm of neutrophils.

ANCA
Antineutrophil Cytoplasmic Antibodies

28

ABs can damage endothelial cells by both antibody-dependent cellular cytotoxicity (ADCC) and complement activation mechanisms.

these ABs directed toward structures on the surface of endothelial cells are NOT found in all vasculitic syndromes.

Antiendothelial antibodies:

29

antigen-driven vascular inflammation. This polymorphism is not shared by patients with rheumatoid arthritis.

T Cell Dependent Mediated Endothelial Cell Injury

30

promote binding of IC and PMNs, express MHC class II genes, enhance local lymphocyte proliferation, and release stimulatory and proliferative cytokines.

These changes may promote the vascular inflammatory response and initiate a T cell proliferative response.

Infection of Endothelial Cells

31

Vasculitis can affect vessels _____

Anywhere

32

Fever
HA
tenderness on side of head
Older person

Giant Cell