PATHOMA- JOINTS Flashcards Preview

BL/DD USMLE and Basics > PATHOMA- JOINTS > Flashcards

Flashcards in PATHOMA- JOINTS Deck (24):
1

Chronic, systemic, autoimmune disorder
Affects mostly middle aged women
HLA-DR4

RA

2

Halmarks of RA

synovitis with pannus formation
destruction of cartilage
possible osteopenia

3

Pannus and it's problems

thickening of the synovium
leads to joint space narrowing
loss of cartilage
joint deviations
ankalyzing

4

Clinical picture of RA

Morning stiffness- better with activity
symmetric joint involvement
DIPs are spared

may have: lymphandopathy, interstitial lung fibrosis

5

Lab findings of RA

RF
inc. neuts and protein in synovial fluid
anemia of chronic disease

6

No RF
Axial skelto
HLA B27

seronegative spondyloarthropathy

No RF (seronegative)
Axial skelton (spondylo)

7

seronegative spondyloarthropathy presentation

Usually in males
presents as low back pain
vertebra may fuse
uveitis
high risk for anyrism

8

Conjunctivitis
urethritis
arthritis
onset after GI/Chlamydia infcetion

Reiter syndrome- seronegative spondyloarthropathy

Can't see, can't pee, can't climb a tree

9

Reiter syndrome clinical picture

10% w/psoriasis
axial/perf joint. Affects DIPs
"sausage digits"

10

Caused in young adults Gonorrhea
in Adults/Kids by S. Aureas

usually single, warm joint with systemic symptoms

Infections Arthritis

11

Deposition of MSU crystals in the tissue
due to hyperuricemia

Gout

12

hyperuricemia causes

increased production
decreased removal

13

Unknown cause of hyperuricemia
usually in adult males

Primary Gout

14

Secondary causes of gout

leukemia
MPD
Lesh Nynn
Renal insufic

15

painful arthritis of great toe
crystals activate neurtophils
Triggers are ETOH and meat

Acute Gout

16

Tophi
Renal Failure

Chronic gout

17

Tophi are

uric acid crystals in soft tissue or joints
may have fibrosis

18

Renal Failure from chronic gout is caused by

Uric acid deposits in the kidney

19

Gout Labs

hyperglycemia
yellow needle shaped crystals

20

______ resembles gout

pseudogout

21

Dermatomyositis

proximal muscle weakness
malar rash
gortons lesions
helitrope rash

22

Dermatomyositis lab findings

inc. CPK
+ana w/ Anti-Jo1
perimysial inflamation

23

Polymyositis vs Dermatomyositis

no skin findings
invades endomysium

24

Lipoma

tumor of the adipose tissue