BL- PM/DM Flashcards Preview

BL/DD USMLE and Basics > BL- PM/DM > Flashcards

Flashcards in BL- PM/DM Deck (17):
1

The erythematous papular rash over the metacarpal or interphalangeal joints that classically occurs in dermatomyositis is known as:

Gottron’s papules

2

features of the Anti-synthetase Syndrome

Arthritis
Raynaud’s phenomenon
Interstitial lung disease
Mechanic’s hands

3

The anti-synthetase antibody, anti-Jo-1, is directed against which aminoacyl-tRNA synthetase?

Histidyl

4

**In polymyositis, the muscle inflammatory cell infiltrate is primarily which cell type:

CD8+ T cells

5

In autoimmune inflammatory myopathies, which laboratory test is elevated in the vast majority of patients with active disease:

Creatine phosphokinase (CPK)

6

DM/PM: Rare autoimmune muscle diseases characterized by _____; other organs may be involved.

symmetric proximal muscle weakness

7

Polymyositis (PM) and dermatomyositis (DM) are the most common of the rare....

autoimmune inflammatory muscle diseases

8

PM/DM my also show signs of

inflammatory arthritis
rash
Raynaud’s phenomenon
interstitial lung disease
myositis-specific antibodies in the anti-synthetase syndrome

9

Elevated levels of serum muscle enzymes (CPK) are present and _____ reveal myopathic findings

Electromyography

10

**endomysial distribution; appears to be a direct CD8+ T cell-mediated muscle injury

Polymyositis

11

**perivascular distribution; CD4+ T cells; perifascicular atrophy; considered in part to be a complement-mediated vasculopathy. There may also be a central role for type I interferons

dermatomyositis

12

DM/PM Treatment is directed at suppressing the:

autoimmune inflammatory response

13

In DM/PM, characterized by chronic muscle weakness and infiltration of muscle tissue by

chronic inflammatory cells

14

Reynolds Phenomena

whiteness/blue in hands

excessively reduced blood flow in response to cold or emotional stress, causing discoloration of the fingers, toes, and occasionally other areas.

15

Inclusion Body Myositis**

inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness.

rimmed vacules and inclusions

16

Anti-synthetase Syndrome

antisynthetase antibodies (which target tRNA synthetase enzymes)

interstitial lung disease
inflammatory myopathy
inflammatory polyarthritis affecting small joints symmetrically
fever
Raynaud's phenomenon
"mechanics hands"-thick

17

interstitial lung disease
inflammatory myopathy
inflammatory polyarthritis affecting small joints symmetrically
fever
Raynaud's phenomenon
"mechanics hands"-thick

Anti-synthetase Syndrome