BL- IMMUNO REVIEW Flashcards Preview

BL/DD USMLE and Basics > BL- IMMUNO REVIEW > Flashcards

Flashcards in BL- IMMUNO REVIEW Deck (18):
1

Murine

fully mouse monoclonal ab
one time use

2

Chiamaric

mouse variable region
Humanized constant region

3

Humanized mAB

Only has mouse CDR

4

Fully humanzied example

Humaria

scid mouse w/ human immune system transplant made into human antibody

5

Natural killer cells have 2 mechanisms:

ADCC- NK targets antibodies
DAMP/PAMP innate immunity

6

Natural KIller cells are also called?

Large Granular Lymphocyte

7

Universal Recipient blood type

AB Rh(D)

8

Direct Antigen vs, Indirect Antigen tests

Direct: tests for AB bound to cell (ex: rbc)

Indirect: Tests for AB in pt serum

9

Rhogram _______ immunization

Prevent

Works in Rh- mothers

10

Can you immunize against ABO

No, exposure occurs in infancy

11

Hemolytic disease of the newborn

an alloimmune condition that develops in a fetus, when the IgG molecules produced by the mother pass through the placenta.
Among these antibodies are some which attack the red blood cells in the fetal circulation

12

Elisa tests for?

Antibody in the patients serum

13

Capture Elisa tests for?

Antigen in pts serum

14

What is the best T cell Test?

Skin test (ex: TB)

15

Proteins to be aware of in HIV

CD4- on t cell
CCR5- co receptor

gp120, gp41 on HIV

16

If MHC decreases, then NK cells ____ in response to tumors

Increase

17

BRAF mutation is present in?

melenoma

18

BCC has a mutation in?

hedgehog/smoothened