PATHOMA- Derm inflam Flashcards Preview

BL/DD USMLE and Basics > PATHOMA- Derm inflam > Flashcards

Flashcards in PATHOMA- Derm inflam Deck (44):
1

Layers of the Epidermis
top to bottome

Corneum
Lucidum
Granulosum
Spinosum
Basale
~BM~
Dermis

2

Stratum corneum contains?

Keratin

3

Stratum spinosum contains?

Desmosomes

4

a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes.

Desmosomes

5

key structural material making up the outer layer of human skin. It is also the key structural component of hair and nails.

Keratin

6

The dermis contains

adnexal structures
Blood vessels
sweat glands
sebaceous glands
connective tissue

7

sebaceous glands

microscopic exocrine glands in the skin that secrete an oily or waxy matter, called sebum, to lubricate and waterproof the skin and hair of mammals

8

The basal cells functions to

Stem cell layer
Creates new epidermis

9

An itchy inflammation of the skin
also known as atopic eczema or eczema

Atopic dermatitis

10

Dermatitis means

inflammation of the skin

11

Atopic dermatitis key points

s/s
pruitic
erthemitic
oozing
vesicles
edema

face/flexor
rx: topical steroids

12

results from exposure to allergens or irritants

Contact dermatitis

13

caused by chemical irritants and those caused by physical irritants.

irritant contact dermatitis

14

manifestation of an allergic response caused by contact with a substance

allergic contact dermatitis

15

Common irritants in irritant contact dermatitis

nickel
poison ivy
detergents
drugs

rx: remove irritant from exposure
Topical steriods

16

chronic inflammation of hair follicle and sebacous glands

acne vulgaris

17

acne vulgaris is caused by?

Hormones leading to increased sebum
excess keratin
*blocked follicle leading to infection by p. acne

18

Inflammation in Acne is the result of?

lipase breaks down xs sebum
release of inflammatory mediators

19

chronic, relapsing/remitting, immune-mediated systemic disease characterized by skin lesions including red, scaly patches, papules, and plaques, which usually itch.

Psoriasis

20

Psoriasis lesions are?

well circumscribed
salmon colored
silver scales

also shows nail pitting

21

Psoriasis are located?

extensor surfaces
scalp

22

Psoriasis is caused by?

possibly autoimmune
excess keratinocytes
HLA-C ass.

23

diffuse epidermal hyperplasia (thickening of the skin).

Acanthosis

24

Cellulitis morphology

warm, tender, red, patch, plaque

25

Cellultisis loction

dermis/sub q tissue

26

Dermatitis location

epidermis/ dermis

27

infection of the upper dermis and superficial lymphatics, usually caused by streptococcus bacteria on scratches or otherwise infected areas

Erysipelas

28

rysipelas is more superficial than cellulitis, and is typically more raised and _______

demarcated.

29

Erysipelas location

dermis
minimal sub q

30

Stasis dermis location?

lower leg

31

Seborrheic dermatitis location?

scalp

32

Atopic dermatitis location?

flexor

33

Psoriasis location?

extensor

*may have arthritis

34

Lower ext. edema

statis dermatitis

35

Malassezia furfur

Seborrheic dermatitis

36

Malassezia is a genus of fungi. Malassezia is naturally found on the:______

skin surfaces

37

Filaggrin

a filament-associated protein that binds to keratin fibers in epithelial cells.

38

Atopic derm etiology

Filaggrin etiology

39

Atopic derm is ass w/?

asthma
alleric rhinitis

40

Allergic contact derm is a _____ rxn

Delayed hypersensitivity

41

Allergic contact derm is confirmed by?

patch testing

42

______ may be ass. w/ cardiovascular disease

Psoriasis

43

Prurtic
Planar
Polygonal
Purple
Papule

Lichen Planus

44

HEP C related inflammatory rash

Lichen Planus