DD-Dermatology and the Epidermis Flashcards
(59 cards)
the structure and functions of the skin
Skin is the largest organ
Fitzpatrick Skin Types
1- Never tans, always burns 2- Tans with difficulty, usually burns 3- Average tanning, sometimes burns 4- Easily tans, rarely burns 5- Very easy to tan, very rarely burns 6- Never burns
Top 5 Skin Diseases
Eczema Acne Bacterial skin diseases Viral Urticaria
melanocyte pigment cells which produce melanin packaged in granules called_________to protect from UV light
melanosomes
black to brown pigment
Eumelanin
yellow to red-brown pigment
Pheomelanin
melanosomes smaller and distributed in clusters above the nucleus in the keratinocyte
Light Skin
melanosomes larger and distributed individually throughout the cytoplasm of the keratinocyte
Dark Skin
1- Never tans, always burns 2- Tans with difficulty, usually burns 3- Average tanning, sometimes burns 4- Easily tans, rarely burns 5- Very easy to tan, very rarely burns 6- Never burns
Fitzpatrick Skin Types
DUE TO TYPE OF MELANIN PRODUCED, AS WELL AS SIZE AND DISTRIBUTION OF MELANOSOMES
Skin Pigmentation
ABSENCE OF MELANOCYTES
Vitiligo
- Decoration/Beauty
- Barrier
- Vitamin D synthesis
- Water Homeostasis
- Thermoregulation
- Insulation/Calorie Reservoir
- Touch/Sensation
Functions of the Skin
Dark Skin
melanosomes larger and distributed individually throughout the cytoplasm of the keratinocyte
Light Skin
melanosomes smaller and distributed in clusters above the nucleus in the keratinocyte
Autoimmune destruction of melanocytes
Acquired depigmentation
Commonly seen in periorificial and acral locations
Microscopic finding is a complete absence of melanocytes
Vitiligo
ABSENCE OF MELANOCYTES
-Water Homeostasis
-Thermoregulation
example?
Sweat
Vitamine D can come from?
Diet
UVB/skin
Epidermis
the outer layer of cells covering an organism
Base of Epidermis
Melanocytes
Langerhans Cell
APC of Epidermis
Innermost layer of the epidermis
Contains small round cells called basal cells
Location of Stem Cells
BASAL CELL LAYER
Attachment point of basal cells to the basal lamina of the dermal epidermal junction
Hemidesmosomes
predominant cell type in the epidermis, the outermost layer of the skin, constituting 90% of the cells found there.
KERATINOCYTES
acute or chronic autoimmune skin disease, involving the formation of blisters
Bullous Pemphigoid
AB to Hemidesmosomes
