Flashcards in Bones, Joints, and Soft Tissue Deck (77)
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1
___ bone cell involved in bone remodeling by coordinating osteoblast and osteocyte activity in response to different stimuli
osteocyte
2
most common skeletal dysplasia
achondroplasia
3
most common lethal form of dwarfism
thantophoric dysplasia
4
most common inherited disorder of connective tissue
osteogenesis imperfecta
5
most lethal type of osteogenesis imperfecta
Type II (usually autosomal recessive)
6
Albers-Schonberg disease is also known as
Osteopetrosus
7
[diagnose]
absent medullary canal, erlenmeyer flask deformity, renal tubular acidosis, diffuse symmetric skeletal sclerosis
osteopetrosis
8
decreased bone mass is called
osteopenia
9
severe osteopenia is called
osteoporosis
10
[diagnose: osteopenia]
cancellous part of the vertebral bodies have a thin trabecular plates and vertebral collapse
postmenopausal osteopenia
11
[diagnose: osteopenia]
cortical part is affected, widened haversian system
if severe, cancellous like appearance
senile osteopenia
12
osteoporosis in menopause is associated with increased ____ and decreased ___ activities
Decreased serum estrogen,
Increased IL1, IL6, TNF, RANK, RANKL, Osteoclast activity
13
osteoporosis in aging is associated with decreased ___
decreased
1. replicative activity of osteoprogenitor cells
2. osteoblast activity
3. matrix-bound growth factor activity
4. physical activity
14
[diagnose]
elderly, axial skeleton, proximal femur, bone pain due to microfacture
histo: increased but disordered and structurally unsound bone mass
"jigsaw puzzle"
can cause high output failure
paget disease
Osteitis deformans
15
[diagnose]
decreased mineral content of bone due to abnormal mineralization
rickets and osteomalacia
16
__
rail-road track like appreance
dissecting osteitis
17
[diagnose: renal ostodystrophy]
decrease BMP-7
Acidosis
increased RANKL
osteopenia
18
[diagnose: renal ostodystrophy]
Acidosis
decreased 1,25 OH2 vitamin D
Decreased calcium
increased PO4
hyperparathyroidism
osteomalacia
19
___ increases PO4, decreases klotho
FGF-23
20
procallus bone is formed ___ week post injury
1 week
21
___ disease
avascular necrosis of ossification centers in children
legg-calve-perthes disease
22
most common etiologic agent in osteomyelitis
Pyogenic Osteomyelitis
23
most common etiologic agent in osteomyelitis in IV drug user
E. coli
pseudomonas
klebsiella
24
most common etiologic agent in osteomyelitis in neonates
H. influenza
GBS
25
most common etiologic agent in osteomyelitis in patients with sickle cel disease
salmonella
26
most common location of osteomyelitis in neonates
metaphyses and epiphyses
27
most common location of osteomyelitis in children
metaphyseal
28
most common location of osteomyelitis in adults
epiphyses and subchondral region
29
___ refers to small intraosseous abscess in osteomyelitis
Brodie abscess
30
