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Flashcards in Bones, Joints, and Soft Tissue Deck (77)
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1

___ bone cell involved in bone remodeling by coordinating osteoblast and osteocyte activity in response to different stimuli

osteocyte

2

most common skeletal dysplasia

achondroplasia

3

most common lethal form of dwarfism

thantophoric dysplasia

4

most common inherited disorder of connective tissue

osteogenesis imperfecta

5

most lethal type of osteogenesis imperfecta

Type II (usually autosomal recessive)

6

Albers-Schonberg disease is also known as

Osteopetrosus

7

[diagnose]

absent medullary canal, erlenmeyer flask deformity, renal tubular acidosis, diffuse symmetric skeletal sclerosis

osteopetrosis

8

decreased bone mass is called

osteopenia

9

severe osteopenia is called

osteoporosis

10

[diagnose: osteopenia]

cancellous part of the vertebral bodies have a thin trabecular plates and vertebral collapse

postmenopausal osteopenia

11

[diagnose: osteopenia]

cortical part is affected, widened haversian system

if severe, cancellous like appearance

senile osteopenia

12

osteoporosis in menopause is associated with increased ____ and decreased ___ activities

Decreased serum estrogen,

Increased IL1, IL6, TNF, RANK, RANKL, Osteoclast activity

13

osteoporosis in aging is associated with decreased ___

decreased

1. replicative activity of osteoprogenitor cells
2. osteoblast activity
3. matrix-bound growth factor activity
4. physical activity

14

[diagnose]

elderly, axial skeleton, proximal femur, bone pain due to microfacture

histo: increased but disordered and structurally unsound bone mass

"jigsaw puzzle"

can cause high output failure

paget disease

Osteitis deformans

15

[diagnose]

decreased mineral content of bone due to abnormal mineralization

rickets and osteomalacia

16

__
rail-road track like appreance

dissecting osteitis

17

[diagnose: renal ostodystrophy]

decrease BMP-7
Acidosis
increased RANKL

osteopenia

18

[diagnose: renal ostodystrophy]

Acidosis
decreased 1,25 OH2 vitamin D
Decreased calcium
increased PO4
hyperparathyroidism

osteomalacia

19

___ increases PO4, decreases klotho

FGF-23

20

procallus bone is formed ___ week post injury

1 week

21

___ disease

avascular necrosis of ossification centers in children

legg-calve-perthes disease

22

most common etiologic agent in osteomyelitis

Pyogenic Osteomyelitis

23

most common etiologic agent in osteomyelitis in IV drug user

E. coli
pseudomonas
klebsiella

24

most common etiologic agent in osteomyelitis in neonates

H. influenza
GBS

25

most common etiologic agent in osteomyelitis in patients with sickle cel disease

salmonella

26

most common location of osteomyelitis in neonates

metaphyses and epiphyses

27

most common location of osteomyelitis in children

metaphyseal

28

most common location of osteomyelitis in adults

epiphyses and subchondral region

29

___ refers to small intraosseous abscess in osteomyelitis

Brodie abscess

30

___ refers to newly developed sleeve of bone around dead bone in osteomyelitis

involucrum