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Flashcards in Inflammation and Repair Deck (28)
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1

Cite the proper sequence of Recruitment of Leukocytes to sites of inflammation

Margination, Rolling, Adhesion, Transmigration (Diapedesis), migration

2

Interleukin that mediates leukocyte recruitment

IL 1

3

___ is a leukocyute-endothelial process that is weak, transient,

Rolling

4

____ is the main adhesion molecule during diapedesis

CD31/PECAM-1

5

Endogenous compounds that play a role in chemotaxis

IL-8, C5a, LTB4

6

What is the dominant infiltrate during a pseudomonas infection

PMNs for several days

7

What is the ligand of selectins?

Sialyl-Lewis X

8

Cite 3 examples of removing the pathologic agent

Intracellular (ROS, NO)
Lysosomal enzymes
Neutrophil extracellular traps (NETs)

9

____ are anti-inflammatory cytokines

Lipoxin (AA metabolite)
TGF beta
IL 10

Bega10 = mataba = lipid = lipoxin

10

____ is found in platelets and neuroendocrine cells that is a potent vasoconstrictor

Serotonin (derived from tryptophan)

11

The enzyme cyclooxygenase produces ___ and ____ from AA

Prostanoids (Vasodilators)
Thromboxane (Vasoconstrictor)

12

____ are eicosanoids that increases vascular permeability and causes bronchospasm

LTC4, D4, E4

Inhibited by LTRAntagonist

13

___ prostanoids that causes vasodilation, and inhibits platelet aggregation

Prostacyclin (PGI2)

14

___ prostanoids that causes vasoconstriction, promotes platelet aggregation

Thromboxane A2
TXA2 = X = shrink

15

___ prostanoids that causes vasodilation, increases vascular permeability

PGD2, PGE2

PGD = drains

16

Cytokine that plays a role in acute inflammation specifically in recruiting neutrophils and monocytes

IL 17

17

Cytokine in chronic inflammation that acts on macrophages and dendritic cells resulting to increased production of IFN gamma

IL12

18

____ pathway in complement system in which C1 binds to Ig-Ag complex

classical

19

___ pathway in complement system that depends on microbial components

alternative

20

___ is the most abundant component in complement systems

C3

21

Anaphylatoxins in complement pathway which promotes histamine release from mast cells

C3a, C5a

C5a are chemoattractants to neutrophils, monocytes, eosinophils and basophils

22

Component of complement pathway that are part of MAC

C5b, C6-9

23

Cytokines that plays a role in endothelial activation, fever, hypotension, and metabolic abnormalities

TNF, IL-1, IL-6

24

___ is the hallmark of granuloma formation

presence of epithelioid cells or giant cells

25

IL 6 dominates during an acute phase response. This will lead to increase in

CRP, Fibrinogen, Amyloid A

26

___ is the most important cytokine for synthesis and deposition of connective tissue

TGF-beta

27

[Abnormalities in tissue repair]

Inadequate formation of granulation tissue

Wound dehiscence

28

____ is the excessive formation of repair components extending beyond the border of the lesion

keloid