Diseases of the Immune System Flashcards Preview

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Flashcards in Diseases of the Immune System Deck (27)
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1

[type of hypersensitivity reactions]

eosinophils, IL5 from TH2, Antigen binds to IgE on basophils and mast cells
edema, smoothmuscle contraction, mucus production

Type 1

2

[type of hypersensitivity reaction]

Antibodies activate C3a and C5a; functional derangement without evidence of cell or tissue injury

Type II

3

[type of hypersensitivity]

deposition of Ag-Ab complex, inflammation, necrotizing vasculitis, arthus reaction (local)

Type III

4

Granzymes found in CD8 T cell mediate direct killing of antigen by

cleaving and activating caspases

5

Best screening test for SLE

ANA

6

Correlates with disease activity of SLE

anti-dsDNA

7

Specific for SLE

anti-smith, anti-dsDNA

8

[class of lupus nephritis]

Normal LM, ICs in mesangium

minimal change disease (Class I)

9

[class of lupus nephritis]

Messangial cell proliferation, granular mesangial Ig and complement WITHOUT involvement of glomerular capillaries

Mesangial proliferative (Class II)

10

<50% of glomeruli involved, wire-loop appearance, subendothelial IC deposits

Focal (Class III)

11

>/50% of glomeruli involved, wire-loop appearance, subendothelial IC deposits

Diffuse (Class IV)

12

diffuse capillary thickening, subepithelial deposits

Membranous (Class V)

13

Dry eyes, dry mouth, destruction of lacrimal and salivary glands

Sjogren Syndrome

14

Chronic Inflammation, damage to small vessels, rubber hose inflexibility of esophagus, sclerotic atrophy of the skin, thinning of the epidermis, intimal thickening of interlobular arteries

Systemic Sclerosis/Scleroderma

15

Components of CREST syndrome

Calcinosis
Reynaud Phenomenon
Esophageal dysmotility
Sclerodactyly
Telangectasia

16

Autoantibodies in diffuse scleroderma

Anti-DNA topoisomerase I

17

[Allorecognition pathway]

Donor Ags presented by recepient APCs to recipient T cells

Indirect pathway

18

Occulocutaneous albinism, immunodeficiency, mild bleeding tendency

Chediak-Higashi syndrome

o,paored phagolysosome

19

NADPH oxidase deficiency

CGD

20

Oral candidiasis, extensive diaper rash, failure to thrive, morbiliform rash due to GVHD; due to adenosine deaminase deficieny

SCID

21

Oral candidiasis, extensive diaper rash, failure to thrive, morbiliform rash due to GVHD; due to adenosine deaminase deficieny

SCID

22

At 5 to 6 months of age, noted infection H. influenzae, S. pneumoniae, S. aureus, enterovirus, giardia lamblia

Bruton aggamoglobinemia

23

Thrombocytopenia, Infections/Immunodeficiency, Eczema

Low IgM, normal IgG, Increased IgA, Increased IgE

Wiskott-Aldrich Syndrome

24

HIV initially infects ___ cells

dendritic

25

[HIV life cycle]

gp120 binds to ____ during attachment

CXCR4 and CCR5

26

[HIV life cycle]

____ is the fusion protein used to integrate itself into host cel

gp41

27

apple green bifringence under polarized light

in the spleen, tapioca-like granules (sago spleen); coalesce of deposits: map-like areas (lardaceous spleen)

amyloidosis