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Flashcards in Skin Deck (50)
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1

Dysplastic nevus is a marker of increased risk of ___

melanoma

2

[diagnosis: melanoma]

basal layer of epidermis involved, no atypia or mitosis

Lentigo

3

[diagnosis: melanoma]

epidermis and dermis involved; atypical cells present in epidermis

atypia and mitosis present

dysplastic nevus

4

[diagnosis: melanoma]

epidermis and superficial dermis involved; atypia present, capable of radial growth; not capable of vertical growth

Early melanoma

5

[diagnosis: melanoma]

epidermis, dermis and other structure involved

atypia present, radial growth capable, vertical growth capable

advanced melanoma

6

melanocytes are ___ cells

melanocyte marker: HMB-45

neural crest cell-derived

marker: S100

7

___ growth in melanoma has a metastatic potential

vertical growth

8

tumor depth in melanoma is the distance between

superficial granular cell layer and deepest intradermal tumor involvement

9

[diagnose]

small pore-like ostia impacted with keratin

small, keratin-filled cyst, exuberant keratin production, basaloid cells, invaginations of keratin

seborrheic keratosis

10

___ sign

rapid increase in seborrheic keratitis. Paraneoplastic syndrome of GI malignancies

Leser-Trelat sign

11

[diagnose]

thickened, hyperpigmented skin, velvel like texture in flexural areas

Histo: basal cell hyperpigmentation WITHOUT melanocytic hyperplasia

acanthosis nigricans

12

[diagnose]

atypical dyskeratotic cells in basal epidermis with intercellular bridges, basophilic degenerative changes in elastic fiber, hyperkeratosis

premalignant lesion to squamous cell CA

Actinic Keratosis

13

most common invasive cancer in humans

basal cell CA

14

second most common tumor arising from sun-exposed areas in older people

squamous cell CA

15

[diagnose]

plaques to nodules with ulceration

Histo: full thickness of epidermis with dermal invation, keratin pearl formation, dyskeratotic cells

Squamous cell CA

16

[diagnose] pearly papules with telangectasia; (rodent ulder)

nests of basaloid with peripheral palisading; stromal retraction

basal cell CA

lower metastatic potential

17

___ syndrome

Multiple BCCA before age 20
medulloblastoma
ovarian fibroma
odontogenic keratocyts
pitls on palms and soles
developmental anomalis

Gorlin Syndrome

18

[diagnose: urticaria]

increase in microvascular permeability of the deeper dermis and subcutaneous fat

urticaria

19

[diagnose]

superficial dermal edema
sparse superficial perivenular mononuclear infiltrate

Mast cell and IgE mediated

urticaria

20

[diagnose: acute eczematous dermatitis]

superficial dermal perivascular mononuclear infiltrate

contact dermatitis

21

[diagnose: acute eczematous dermatitis]

superficial and deep dermal perivascular lymphocytic infiltrate with eosinophils

Internal

22

[diagnose]

hyperkeratosis
acanthosis
spongios

acute eczematous dermatitis

23

Dermal edema can seep into this skin layer causing intraepidermal vesicles

stratum spinosus

24

[diagnose]

patient took antimalarials

red macule or papule with a pale, vesicular, or eroded center; superficial perivascular, lymphocytic infiltrate; dermal edema

Erythema multiforme

25

[spectrum of erythema multiforme]

>30% BSA, split formed by bliseter at dermoepidermal junction

TEN

26

accumulation of these cells in the epidermis leads to cytokine and growth factor over production leading to epidermal cell proliferation

CD4 TH1
TH17
CD8

27

[diagnose]

salmon-colored plaques covered by loosely adherent silvery-white scales

psoriasis

28

[diagnose]

test tubes in a rack appearance, munro microabscesses, spongiform pustules of Kogoj

psoriasis

29

[psoriasis]
____
neutrophils in spongiotic foci of the superficial epidermis

Spongiform pustules of Kojog

30

[psoriasis]

neutrophils within the parakeratotic stratum corneum

munro microabcesses

31

test tubes in a rack appearance in psoriasis is due to elongation of?

rete ridges

32

[diagnose]

follicular lipping: mounds of parakeratosis containing PMNs and sebum at the ostia of hair follicle

seborrheic dermatitis

33

[lichen planus]

white dots/lines on papules

wickham striae

34

[diagnose]

pruritic, purple, polygonal, planar papules and plaques

Histo: epiderma hyperplasia, hyperkeratosism hypergranulosis, interface dermatosis

Sawtooth appearance of DEJ

civatte or colloid bodies

lichen planus

35

keratinocytes in the epidermis are connected to each other by ___

desmosomes

36

basal cells in the skin are anchored to the basement membrane by ___

hemidesmosomes

37

___ is the target structure in pemphigus vulgaris resulting acantholysis

desmoglein

38

[diagnose]

suprabasilar blister, lacelike fluorescence patter, Ig G deposits in squamous region, acantholysis, positive nikolsky sign

Pemphigus vulgaris

39

this is the targe structure in bullous pemphigoid antigen

hemidesmosome

40

[diagnose]

IgG deposition in the epidermal basement membrane zone, subepidermal blisters linear patter, no acanthiolysis, negative nikolsky sign

bullous pemphigoid

41

target of antigen in dermatitis herpetiformis

reticulin

42

[diagnose]

subepidermal blister, IgA deposition in the epidermal basement membrane, granular pattern with fibrin and PMNs at tips of dermal papillae

dermatitis herpetiformis

43

Paraneoplastic pemphigus is associated with

NHL

44

dematitis herpetiformis is associated with

celiac disease

45

[diagnosis]

defect in keratin, laminin and BPAGs, and type VII collagen

epidermolysis bullosa

46

[diagnosis]

Inherited defect in heme metabolism; blocks late in heme synthesis lead to sun-induced skin damage

porphyria

47

[diagnose]

histologic hallmark is comedogenesis

acne vulgaris

48

[diagnose, identify the etiologic agent]

gray-white to tan, flat to convex papules, with pebbly surface

Histo: papillimatous epidermal hyperplasia; koilocytic change

HPV

this is a case of Verucae

49

[diagnose, identify the etiologic agent]

pruritic, pink to skin-colored papules with central umbilication

Histo: large, ellipsoid, homogenous, cytoplasmic inclusions in stratum granulosum and corneum

poxvirus

Molluscum contangiosum

50

[diagnose, identify the etiologic agent]

honey-colored crust, bullae

Histo: accumulation of neutrophils beneath the stratum corneum

GABHS (contangiosa)
S. aureus (bullosa)

Impetigo