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Flashcards in Liver and Gallbladder Deck (66)
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1

reversible liver injury

steatosis and cholestasis

2

irreversible liver injury

necrosis and apoptosis

3

vitamin A storage cells in the liver

hepatic stellate cells

4

markers of hepatocyte integrity

AST, ALT, LDH

5

markers of hepatocyte synthetic function

albumin, PT, aPTT, ammonia

6

[diagnosis]
jaundice, cholestasis, hepatic encephalopathy, asterixis, occurring within 26 weeks post initial insult

acute liver injury

7

most common drug that cause acute liver failure

acetaminophen

8

Acute liver failure causes
ABCDEF

A hepatitis, acetaminophen
B hepatitis
C hepatitis, cryptogenic
D hepatitis, drugs/toxins
E hepatitis
F atty liver

9

hepatitis virus that can cause chronic hep infection

HBV, HCV

10

[diagnosis]
jaundice with pruritus,
palmar erythema, spider angiomas, hypogonadism, gynecomastia, HPO axis abnormalities, portal HPN

chronic lover disease

11

[veins involved]

Portocaval anastomoses causing esophageal varices

esophageal branch of the left gastric vein and azygous vein

12

[veins involved]

Portocaval anastomoses causing hemorrhoids

superior, middle, and inferior rectal veins

13

[veins involved]

Portocaval anastomoses causing caput medusae

periumbilical veins and abdominal wall collaterals

14

hallmark of chronic viral hepatitis

portal inflammation

15

[diagnosis: hepatitis]

ground glass appearance of hepatocytes.

hepatitis b

16

[diagnosis: hepatitis]

lymphoid follicles, bile duct injury and steatosis (fatty change)

hepatitis c

17

[diagnosis: acute vs chronic]

ballooning degerenration, apoptosis, macrophages aggregates, scan mononuclear infiltrate

acute hepatitis

18

[diagnosis: acute vs chronic]
dense mononuclear necrosis, ground glass cells (Hep B) or fatty change (hep C), interface hepatitis, ductular reaction, bridging fibrosis

chronic hepatits

19

this refers to stem cell activation of hepatocyte during regeneration

ductular reaction

20

[diagnosis: autoimmune hepatitis]

female, middle aged, ANA, AntiSMA, anti-SLA/LP, AMA

more favorable prognosis

Type 1 Autoimmune Hepatitis

21

[diagnosis: autoimmune hepatitis

female, children to teenagers, anti LKM, CYP2D6 antibodies, anti ACL1

less favorable prognosis

Type 2 autoimmune hepatitis

22

anesthetic drug that causes dose-dependent hepatitis

halothane

23

this drug causes cholestasis leading to hepatitis

chlorpromazine

24

___ amount of alcohol that is associated with development of ALD

80g/day

25

[form of alcoholic liver disease]

lipid droplets in hepatocytes, fatty changes, perivenular fibrosis

hepatocellular steatosis

26

[form of alcoholic liver disease]

hepatocyte swelling, mallory denk bodies, neutrophilic infiltration

alcoholic steatosis

27

[form of alcoholic liver disease]

fibrosis at central vein, perisinusoidal, chicken-wire fence pattern

steatofibrosis

28

[alcoholic SH vs non-alcoholic SH]

PMN predominant, fibrosis prominent around central vein, mallory denk bodies are more

Alcoholic steatohepatitis

29

alcoholic SH vs non-alcoholic SH]

mononuclear infiltrates, fibrosis prominent around portal vein, less mallory denk bodies

Non-alcoholic SH

30

[diagnosis]

1. micronodular cirrhosis
2. Diabetes mellitus
3. abnormal skin pigmentation

hemochromatosis