Flashcards in WBC, LN, Spleen Deck (58)
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1
cut off value for clinically significant neutropenia
<500/mm3
considered agranulocytosis
2
most common cause of agranulocytosis
drug toxicity
3
___ syndrome is associated with inadequate of ineffective granulopoiesis
kostmann syndrome
4
___ syndrome of ineffective hematopoeisis. abnormal cells die before they can go out of the marrow resulting to low peripheral blood counts and compensatory hypercellular marrow
myelodysplastic syndrome
5
___ center is the area of B-cell activation
germinal center
6
___ zone contains small, naive B cells in LN
mantle zone
7
pattern of hyperplasia seen in acute viral infections; mottled appearance
paracortical hyperplasia
8
[diagnosis]
younger, primitive cells, aggressive clinical course, amenable to treatment
Acute leukemia
9
[diagnosis]
older, mature looking cells, indolent clinical course, subtle symptoms, resistant to treatment
chronic leukemia
10
sanctuary sites of Bcell ALL and T cell ALL
testis
11
this refers to absence of blasts in peripheral blood; >100,000/mm3
aleukemic leukemia
12
t(15;17)
APML
13
t(12;21)
B-CELL ALL
14
NOTCH-1 mutation
T-CELL ALL
15
[diagnosis]
needle-like azurophilic granules
APML
auer rods
16
___ cells when there are numerous auer rods. seen in APML. Associated with DIC
faggot cells
17
[diagnosis]
constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, >5,000/mm3 PBS, small lymphocytes with smudge cells
CLL
18
[diagnosis]
constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, <5,000/mm3 PBS, small lymphocytes with smudge cells
SLL
19
Chronic lymphomas that can undergo Richter Syndrome
CLL, SLL
20
progression of CLL to DLBCL is called
richter syndrome
21
t(9;22)
CML
22
[diagnosis]
WBC >100,000/ mm3
thrombocytosis
Blast <10% in PBS
CML
23
[diagnosis of CML phase]
1. Increasing WBC unresponsive to therapy
2. Basophils >20%
3. Thrombocytes <100,000 unrelated to therapy OR
4. >1,000,000 unresponsive to therapy
5. increasing splenomegaly
Accelerated phase
24
____ (low/high) leukocyte alkaline phosphatase level in CML
low
25
receptor used by drugs in treating CML
Tyrosine Kinase
DOC: imatinib
26
[diagnosis]
LN: large, multiple nuclei or single with multiple lobes, each with nucleolous
Hodgkin lymphoma
27
[subtype of HL]
Reactive T-cells with fibrous bands forming nodules, not associated with EBV
nodular sclerosis
28
[subtype of HL]
mixed leukocytic infiltrate without fibrous nodules, 70% associated with EBC
mixed cellularuty
29
[subtype of HL]
rich reactive T-cell infiltrate, 40% associated with EBV
lymphocyte rich
30
