WBC, LN, Spleen Flashcards Preview

Question 1

1

cut off value for clinically significant neutropenia

Answer

<500/mm3

considered agranulocytosis

Question 2

2

most common cause of agranulocytosis

Answer

drug toxicity

Question 3

3

___ syndrome is associated with inadequate of ineffective granulopoiesis

Answer

kostmann syndrome

Question 4

4

___ syndrome of ineffective hematopoeisis. abnormal cells die before they can go out of the marrow resulting to low peripheral blood counts and compensatory hypercellular marrow

Answer

myelodysplastic syndrome

Question 5

5

___ center is the area of B-cell activation

Answer

germinal center

Question 6

6

___ zone contains small, naive B cells in LN

Answer

mantle zone

Question 7

7

pattern of hyperplasia seen in acute viral infections; mottled appearance

Answer

paracortical hyperplasia

Question 8

8

[diagnosis]

younger, primitive cells, aggressive clinical course, amenable to treatment

Answer

Acute leukemia

Question 9

9

[diagnosis]

older, mature looking cells, indolent clinical course, subtle symptoms, resistant to treatment

Answer

chronic leukemia

Question 10

10

sanctuary sites of Bcell ALL and T cell ALL

testis

Answer

aleukemic leukemia

Answer

B-CELL ALL

Answer

T-CELL ALL

Answer

APML

auer rods

Answer

faggot cells

Answer

richter syndrome

Answer

Accelerated phase

Answer

Tyrosine Kinase

DOC: imatinib

Answer

Hodgkin lymphoma

Answer

nodular sclerosis

Answer

mixed cellularuty

Answer

lymphocyte rich

Answer

lymphocyte depleted

Answer

Lymphocyte predominant

Answer

ann arbor classification

Answer

follicular lymphoma

Answer

Follicular lymphoma

Answer

Hodgkin lymphoma

Answer

non-hodgkin lymphoma

Answer

Diffuse large B-cell lymphoma

Answer

CD45, Cytokeratin, vimentin

Answer

Burkitt lymphoma

Answer

Endemic burkitt

Answer

Sporadic burkitt

Answer

burkitt lymphoma

Answer

marginal zone lymphoma

Answer

mycosis fungoides/Cutaneous T cell lymphoma

Answer

Sezary Syndrome

Answer

Multiple myeloma

Answer

Multiple myeloma

Answer

erythroid MDS

Answer

granulocytic MDS

pseudo pelger huet cell

Answer

Granulocytic MDS

Answer

megakaryocytic MDS

Answer

megakaryocytic MDS

Answer

Essential Thrombocytopenia

Answer

Primary myelofibrosis

Answer

langerhands histiocytosis

Answer

langerhans histiocytosis

Question 11

11

this refers to absence of blasts in peripheral blood; >100,000/mm3

Question 12

12

t(15;17)

APML

Question 13

13

t(12;21)

Question 14

14

NOTCH-1 mutation

Question 15

15

[diagnosis]

needle-like azurophilic granules

Question 16

16

___ cells when there are numerous auer rods. seen in APML. Associated with DIC

Question 17

17

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, >5,000/mm3 PBS, small lymphocytes with smudge cells

CLL

Question 18

18

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, <5,000/mm3 PBS, small lymphocytes with smudge cells

SLL

Question 19

19

Chronic lymphomas that can undergo Richter Syndrome

CLL, SLL

Question 20

20

progression of CLL to DLBCL is called

Question 21

21

t(9;22)

CML

Question 22

22

[diagnosis]

WBC >100,000/ mm3
thrombocytosis
Blast <10% in PBS

CML

Question 23

23

[diagnosis of CML phase]

1. Increasing WBC unresponsive to therapy
2. Basophils >20%
3. Thrombocytes <100,000 unrelated to therapy OR
4. >1,000,000 unresponsive to therapy
5. increasing splenomegaly

Question 24

24

____ (low/high) leukocyte alkaline phosphatase level in CML

low

Question 25

25

receptor used by drugs in treating CML

Question 26

26

[diagnosis]

LN: large, multiple nuclei or single with multiple lobes, each with nucleolous

Question 27

27

[subtype of HL]

Reactive T-cells with fibrous bands forming nodules, not associated with EBV

Question 28

28

[subtype of HL]

mixed leukocytic infiltrate without fibrous nodules, 70% associated with EBC

Question 29

29

[subtype of HL]

rich reactive T-cell infiltrate, 40% associated with EBV

Question 30

30

[subtype of HL]

rare reactive lymphocyte, CD15 + and CD 30 +; mostly associated with EBV

Question 31

31

[subtype of HL]
reactive B cells, popcorn reed steinberg cells, not associated with EBV

CD15 (-)
CD30 (-)
CD20 (+)

Question 32

32

staging system used in hodgkin lymphoma

Question 33

33

most common indolent lymphoma of adults

Question 34

34

[diagnosis]
painless, generalized lymphadenopathy,

BMA: paratrabecular lymphoid aggregates, can undergo richter syndrome

transform to DLBCL or Burkitt lymphoma

Question 35

35

[diagnosis]

LN involved: single, axial group of nodes (cervical, mediastinal, para-aortic, contiguous spread

Question 36

36

[diagnosis]

LN involvement: multiple, peripheral LN, non-contiguous spread, has extranodal presentation,

mesenteric and waldeyer ring are commonly involved

Question 37

37

most common lymphoma of adults

Question 38

38

[diagnosis]

approx 60/M rapidly enlarging mass at nodal or extranodal site,
histologically, diffuse pattern of growth; large cell with highly anaplastic appearance

DLBCL

Question 39

39

Immunostains used in DLBCL

Question 40

40

fastest growing human tumor

Question 41

41

[diagnosis]

children/young adults, mandibular mass, 100% latent infection with EBV

Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

Question 42

42

[diagnosis]

children/young adults, ileocecum, peritoneal mass, 15-20% latent infection with EBV

Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

Question 43

43

t(8;14) mutation

Question 44

44

[diagnosis, type of NHL]

type of lymphoma that can arise in salivary glands (sjogren syndrome), thyroid gland (hashimoto thyroiditis), stomach (H. pylori)

Question 45

45

[diagnosis]

infiltration of epidermis and upper dermis T cells with cerebriform nuclei

Question 46

46

____ syndrome associated with mycosis fungoides characterized as generalized exfloative erythroderma and leukemia T-cells with cerebriform nuclei

Question 47

47

[diagnosis]

65-75 years old, PAS(+) cytoplasmic (russel bodies) or nuclear inclusion (dutcher bodies) containing Ig

Question 48

48

[diagnosis]

punched out bone lesions, bence-jone proteinuria, hypercalcemia

Question 49

49

[type of MDS]

Prussian blue (+) iron-laden mitochondria in erythroblast, megaloblastoid maturation, nuclear budding, abnormalities, mishapen polypoid nuclei

Question 50

50

[type of MDS]
presence of PMNs with only 2 lobes

Question 51

51

[diagnosis]

pseudo Pelger Huet Cell

Question 52

52

[type of MDS]

megakaryocyte with multiple separated nuclei

Question 53

53

[diagnosis]

pawn ball megakaryocyte

Question 54

54

[diagnosis]

JAK2 mutation

plethoric, thrombosis, infarcts, hemorrahge, hyperuricemia, gout, throbbing and burning of hands and feet due to thrombotic occlusion by platelet aggregates

PV

Question 55

55

[diagnosis]

Thrombosis, infarcts, hemorrhage, escape of erythroid and granulocytic precursos into circulation and sites of extramedullary hematopoiesis

Question 56

56

[diagnosis]

extensive deposition of collagen in marrow by non-neoplastic fibroblasts; WBC and platelet predominance, pronounced hepatosplenomegaly, hyperuricemia/gout,

presence of dacrocytes, fibrotic marrow converted into bone, osteo sclerosis

Question 57

57

[diagnosis]

proliferative disorder of dendritic cells in skin, presence of birbeck granules, presence of racket shaped granules

Question 58

58

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WBC, LN, Spleen Flashcards Preview

Pathology > WBC, LN, Spleen > Flashcards

cut off value for clinically significant neutropenia

<500/mm3considered agranulocytosis

most common cause of agranulocytosis

drug toxicity

___ syndrome is associated with inadequate of ineffective granulopoiesis

kostmann syndrome

___ syndrome of ineffective hematopoeisis. abnormal cells die before they can go out of the marrow resulting to low peripheral blood counts and compensatory hypercellular marrow

myelodysplastic syndrome

___ center is the area of B-cell activation

germinal center

___ zone contains small, naive B cells in LN

mantle zone

pattern of hyperplasia seen in acute viral infections; mottled appearance

paracortical hyperplasia

[diagnosis]younger, primitive cells, aggressive clinical course, amenable to treatment

Acute leukemia

[diagnosis]older, mature looking cells, indolent clinical course, subtle symptoms, resistant to treatment

chronic leukemia

sanctuary sites of Bcell ALL and T cell ALL

testis

this refers to absence of blasts in peripheral blood; >100,000/mm3

aleukemic leukemia

t(15;17)

APML

t(12;21)

B-CELL ALL

NOTCH-1 mutation

T-CELL ALL

[diagnosis]needle-like azurophilic granules

APMLauer rods

___ cells when there are numerous auer rods. seen in APML. Associated with DIC

faggot cells

[diagnosis]constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, >5,000/mm3 PBS, small lymphocytes with smudge cells

CLL

[diagnosis]constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, <5,000/mm3 PBS, small lymphocytes with smudge cells

SLL

Chronic lymphomas that can undergo Richter Syndrome

CLL, SLL

progression of CLL to DLBCL is called

richter syndrome

t(9;22)

CML

[diagnosis]WBC >100,000/ mm3thrombocytosisBlast <10% in PBS

CML

[diagnosis of CML phase]1. Increasing WBC unresponsive to therapy2. Basophils >20%3. Thrombocytes <100,000 unrelated to therapy OR4. >1,000,000 unresponsive to therapy5. increasing splenomegaly

Accelerated phase

____ (low/high) leukocyte alkaline phosphatase level in CML

low

receptor used by drugs in treating CML

Tyrosine KinaseDOC: imatinib

[diagnosis]LN: large, multiple nuclei or single with multiple lobes, each with nucleolous

Hodgkin lymphoma

[subtype of HL]Reactive T-cells with fibrous bands forming nodules, not associated with EBV

nodular sclerosis

[subtype of HL]mixed leukocytic infiltrate without fibrous nodules, 70% associated with EBC

mixed cellularuty

[subtype of HL]rich reactive T-cell infiltrate, 40% associated with EBV

lymphocyte rich

[subtype of HL]rare reactive lymphocyte, CD15 + and CD 30 +; mostly associated with EBV

lymphocyte depleted

[subtype of HL]reactive B cells, popcorn reed steinberg cells, not associated with EBVCD15 (-)CD30 (-)CD20 (+)

Lymphocyte predominant

staging system used in hodgkin lymphoma

ann arbor classification

most common indolent lymphoma of adults

follicular lymphoma

[diagnosis]painless, generalized lymphadenopathy, BMA: paratrabecular lymphoid aggregates, can undergo richter syndrometransform to DLBCL or Burkitt lymphoma

Follicular lymphoma

[diagnosis]LN involved: single, axial group of nodes (cervical, mediastinal, para-aortic, contiguous spread

Hodgkin lymphoma

[diagnosis]LN involvement: multiple, peripheral LN, non-contiguous spread, has extranodal presentation, mesenteric and waldeyer ring are commonly involved

non-hodgkin lymphoma

most common lymphoma of adults

Diffuse large B-cell lymphoma

[diagnosis]approx 60/M rapidly enlarging mass at nodal or extranodal site,histologically, diffuse pattern of growth; large cell with highly anaplastic appearance

DLBCL

Immunostains used in DLBCL

Brainscape's Knowledge Genome^TM

<500/mm3

considered agranulocytosis

[diagnosis]

younger, primitive cells, aggressive clinical course, amenable to treatment

[diagnosis]

older, mature looking cells, indolent clinical course, subtle symptoms, resistant to treatment

[diagnosis]

needle-like azurophilic granules

APML

auer rods

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, >5,000/mm3 PBS, small lymphocytes with smudge cells

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, <5,000/mm3 PBS, small lymphocytes with smudge cells

[diagnosis]

WBC >100,000/ mm3
thrombocytosis
Blast <10% in PBS

[diagnosis of CML phase]

1. Increasing WBC unresponsive to therapy
2. Basophils >20%
3. Thrombocytes <100,000 unrelated to therapy OR
4. >1,000,000 unresponsive to therapy
5. increasing splenomegaly

Tyrosine Kinase

DOC: imatinib

[diagnosis]

LN: large, multiple nuclei or single with multiple lobes, each with nucleolous

[subtype of HL]

Reactive T-cells with fibrous bands forming nodules, not associated with EBV

[subtype of HL]

mixed leukocytic infiltrate without fibrous nodules, 70% associated with EBC

[subtype of HL]

rich reactive T-cell infiltrate, 40% associated with EBV

[subtype of HL]

rare reactive lymphocyte, CD15 + and CD 30 +; mostly associated with EBV

[subtype of HL]
reactive B cells, popcorn reed steinberg cells, not associated with EBV

CD15 (-)
CD30 (-)
CD20 (+)

[diagnosis]
painless, generalized lymphadenopathy,

BMA: paratrabecular lymphoid aggregates, can undergo richter syndrome

transform to DLBCL or Burkitt lymphoma

[diagnosis]

LN involved: single, axial group of nodes (cervical, mediastinal, para-aortic, contiguous spread

[diagnosis]

LN involvement: multiple, peripheral LN, non-contiguous spread, has extranodal presentation,

mesenteric and waldeyer ring are commonly involved

[diagnosis]

approx 60/M rapidly enlarging mass at nodal or extranodal site,
histologically, diffuse pattern of growth; large cell with highly anaplastic appearance

[diagnosis]

children/young adults, mandibular mass, 100% latent infection with EBV

Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

[diagnosis]

children/young adults, ileocecum, peritoneal mass, 15-20% latent infection with EBV

Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

[diagnosis, type of NHL]

type of lymphoma that can arise in salivary glands (sjogren syndrome), thyroid gland (hashimoto thyroiditis), stomach (H. pylori)

[diagnosis]

infiltration of epidermis and upper dermis T cells with cerebriform nuclei

[diagnosis]

65-75 years old, PAS(+) cytoplasmic (russel bodies) or nuclear inclusion (dutcher bodies) containing Ig

[diagnosis]

punched out bone lesions, bence-jone proteinuria, hypercalcemia

[type of MDS]

Prussian blue (+) iron-laden mitochondria in erythroblast, megaloblastoid maturation, nuclear budding, abnormalities, mishapen polypoid nuclei

[type of MDS]
presence of PMNs with only 2 lobes

granulocytic MDS

pseudo pelger huet cell

[diagnosis]

pseudo Pelger Huet Cell

[type of MDS]

megakaryocyte with multiple separated nuclei

[diagnosis]

pawn ball megakaryocyte

[diagnosis]

JAK2 mutation

plethoric, thrombosis, infarcts, hemorrahge, hyperuricemia, gout, throbbing and burning of hands and feet due to thrombotic occlusion by platelet aggregates

[diagnosis]

Thrombosis, infarcts, hemorrhage, escape of erythroid and granulocytic precursos into circulation and sites of extramedullary hematopoiesis

[diagnosis]

extensive deposition of collagen in marrow by non-neoplastic fibroblasts; WBC and platelet predominance, pronounced hepatosplenomegaly, hyperuricemia/gout,

presence of dacrocytes, fibrotic marrow converted into bone, osteo sclerosis

[diagnosis]

proliferative disorder of dendritic cells in skin, presence of birbeck granules, presence of racket shaped granules

[diagnosis]

birbeck granules, pentalaminar racket-shaped granules