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Flashcards in WBC, LN, Spleen Deck (58)
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1

cut off value for clinically significant neutropenia

<500/mm3

considered agranulocytosis

2

most common cause of agranulocytosis

drug toxicity

3

___ syndrome is associated with inadequate of ineffective granulopoiesis

kostmann syndrome

4

___ syndrome of ineffective hematopoeisis. abnormal cells die before they can go out of the marrow resulting to low peripheral blood counts and compensatory hypercellular marrow

myelodysplastic syndrome

5

___ center is the area of B-cell activation

germinal center

6

___ zone contains small, naive B cells in LN

mantle zone

7

pattern of hyperplasia seen in acute viral infections; mottled appearance

paracortical hyperplasia

8

[diagnosis]

younger, primitive cells, aggressive clinical course, amenable to treatment

Acute leukemia

9

[diagnosis]

older, mature looking cells, indolent clinical course, subtle symptoms, resistant to treatment

chronic leukemia

10

sanctuary sites of Bcell ALL and T cell ALL

testis

11

this refers to absence of blasts in peripheral blood; >100,000/mm3

aleukemic leukemia

12

t(15;17)

APML

13

t(12;21)

B-CELL ALL

14

NOTCH-1 mutation

T-CELL ALL

15

[diagnosis]

needle-like azurophilic granules

APML

auer rods

16

___ cells when there are numerous auer rods. seen in APML. Associated with DIC

faggot cells

17

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, >5,000/mm3 PBS, small lymphocytes with smudge cells

CLL

18

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, <5,000/mm3 PBS, small lymphocytes with smudge cells

SLL

19

Chronic lymphomas that can undergo Richter Syndrome

CLL, SLL

20

progression of CLL to DLBCL is called

richter syndrome

21

t(9;22)

CML

22

[diagnosis]

WBC >100,000/ mm3
thrombocytosis
Blast <10% in PBS

CML

23

[diagnosis of CML phase]

1. Increasing WBC unresponsive to therapy
2. Basophils >20%
3. Thrombocytes <100,000 unrelated to therapy OR
4. >1,000,000 unresponsive to therapy
5. increasing splenomegaly

Accelerated phase

24

____ (low/high) leukocyte alkaline phosphatase level in CML

low

25

receptor used by drugs in treating CML

Tyrosine Kinase

DOC: imatinib

26

[diagnosis]

LN: large, multiple nuclei or single with multiple lobes, each with nucleolous

Hodgkin lymphoma

27

[subtype of HL]

Reactive T-cells with fibrous bands forming nodules, not associated with EBV

nodular sclerosis

28

[subtype of HL]

mixed leukocytic infiltrate without fibrous nodules, 70% associated with EBC

mixed cellularuty

29

[subtype of HL]

rich reactive T-cell infiltrate, 40% associated with EBV

lymphocyte rich

30

[subtype of HL]

rare reactive lymphocyte, CD15 + and CD 30 +; mostly associated with EBV

lymphocyte depleted