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Flashcards in WBC, LN, Spleen Deck (58)
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1

cut off value for clinically significant neutropenia

<500/mm3

considered agranulocytosis

2

most common cause of agranulocytosis

drug toxicity

3

___ syndrome is associated with inadequate of ineffective granulopoiesis

kostmann syndrome

4

___ syndrome of ineffective hematopoeisis. abnormal cells die before they can go out of the marrow resulting to low peripheral blood counts and compensatory hypercellular marrow

myelodysplastic syndrome

5

___ center is the area of B-cell activation

germinal center

6

___ zone contains small, naive B cells in LN

mantle zone

7

pattern of hyperplasia seen in acute viral infections; mottled appearance

paracortical hyperplasia

8

[diagnosis]

younger, primitive cells, aggressive clinical course, amenable to treatment

Acute leukemia

9

[diagnosis]

older, mature looking cells, indolent clinical course, subtle symptoms, resistant to treatment

chronic leukemia

10

sanctuary sites of Bcell ALL and T cell ALL

testis

11

this refers to absence of blasts in peripheral blood; >100,000/mm3

aleukemic leukemia

12

t(15;17)

APML

13

t(12;21)

B-CELL ALL

14

NOTCH-1 mutation

T-CELL ALL

15

[diagnosis]

needle-like azurophilic granules

APML

auer rods

16

___ cells when there are numerous auer rods. seen in APML. Associated with DIC

faggot cells

17

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, >5,000/mm3 PBS, small lymphocytes with smudge cells

CLL

18

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, <5,000/mm3 PBS, small lymphocytes with smudge cells

SLL

19

Chronic lymphomas that can undergo Richter Syndrome

CLL, SLL

20

progression of CLL to DLBCL is called

richter syndrome

21

t(9;22)

CML

22

[diagnosis]

WBC >100,000/ mm3
thrombocytosis
Blast <10% in PBS

CML

23

[diagnosis of CML phase]

1. Increasing WBC unresponsive to therapy
2. Basophils >20%
3. Thrombocytes <100,000 unrelated to therapy OR
4. >1,000,000 unresponsive to therapy
5. increasing splenomegaly

Accelerated phase

24

____ (low/high) leukocyte alkaline phosphatase level in CML

low

25

receptor used by drugs in treating CML

Tyrosine Kinase

DOC: imatinib

26

[diagnosis]

LN: large, multiple nuclei or single with multiple lobes, each with nucleolous

Hodgkin lymphoma

27

[subtype of HL]

Reactive T-cells with fibrous bands forming nodules, not associated with EBV

nodular sclerosis

28

[subtype of HL]

mixed leukocytic infiltrate without fibrous nodules, 70% associated with EBC

mixed cellularuty

29

[subtype of HL]

rich reactive T-cell infiltrate, 40% associated with EBV

lymphocyte rich

30

[subtype of HL]

rare reactive lymphocyte, CD15 + and CD 30 +; mostly associated with EBV

lymphocyte depleted

31

[subtype of HL]
reactive B cells, popcorn reed steinberg cells, not associated with EBV

CD15 (-)
CD30 (-)
CD20 (+)

Lymphocyte predominant

32

staging system used in hodgkin lymphoma

ann arbor classification

33

most common indolent lymphoma of adults

follicular lymphoma

34

[diagnosis]
painless, generalized lymphadenopathy,

BMA: paratrabecular lymphoid aggregates, can undergo richter syndrome

transform to DLBCL or Burkitt lymphoma

Follicular lymphoma

35

[diagnosis]

LN involved: single, axial group of nodes (cervical, mediastinal, para-aortic, contiguous spread

Hodgkin lymphoma

36

[diagnosis]

LN involvement: multiple, peripheral LN, non-contiguous spread, has extranodal presentation,

mesenteric and waldeyer ring are commonly involved

non-hodgkin lymphoma

37

most common lymphoma of adults

Diffuse large B-cell lymphoma

38

[diagnosis]

approx 60/M rapidly enlarging mass at nodal or extranodal site,
histologically, diffuse pattern of growth; large cell with highly anaplastic appearance

DLBCL

39

Immunostains used in DLBCL

CD45, Cytokeratin, vimentin

40

fastest growing human tumor

Burkitt lymphoma

41

[diagnosis]

children/young adults, mandibular mass, 100% latent infection with EBV

Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

Endemic burkitt

42

[diagnosis]

children/young adults, ileocecum, peritoneal mass, 15-20% latent infection with EBV

Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

Sporadic burkitt

43

t(8;14) mutation

burkitt lymphoma

44

[diagnosis, type of NHL]

type of lymphoma that can arise in salivary glands (sjogren syndrome), thyroid gland (hashimoto thyroiditis), stomach (H. pylori)

marginal zone lymphoma

45

[diagnosis]

infiltration of epidermis and upper dermis T cells with cerebriform nuclei

mycosis fungoides/Cutaneous T cell lymphoma

46

____ syndrome associated with mycosis fungoides characterized as generalized exfloative erythroderma and leukemia T-cells with cerebriform nuclei

Sezary Syndrome

47

[diagnosis]

65-75 years old, PAS(+) cytoplasmic (russel bodies) or nuclear inclusion (dutcher bodies) containing Ig

Multiple myeloma

48

[diagnosis]

punched out bone lesions, bence-jone proteinuria, hypercalcemia

Multiple myeloma

49

[type of MDS]

Prussian blue (+) iron-laden mitochondria in erythroblast, megaloblastoid maturation, nuclear budding, abnormalities, mishapen polypoid nuclei

erythroid MDS

50

[type of MDS]
presence of PMNs with only 2 lobes

granulocytic MDS

pseudo pelger huet cell

51

[diagnosis]

pseudo Pelger Huet Cell

Granulocytic MDS

52

[type of MDS]

megakaryocyte with multiple separated nuclei

megakaryocytic MDS

53

[diagnosis]

pawn ball megakaryocyte

megakaryocytic MDS

54

[diagnosis]

JAK2 mutation

plethoric, thrombosis, infarcts, hemorrahge, hyperuricemia, gout, throbbing and burning of hands and feet due to thrombotic occlusion by platelet aggregates

PV

55

[diagnosis]

Thrombosis, infarcts, hemorrhage, escape of erythroid and granulocytic precursos into circulation and sites of extramedullary hematopoiesis

Essential Thrombocytopenia

56

[diagnosis]

extensive deposition of collagen in marrow by non-neoplastic fibroblasts; WBC and platelet predominance, pronounced hepatosplenomegaly, hyperuricemia/gout,

presence of dacrocytes, fibrotic marrow converted into bone, osteo sclerosis

Primary myelofibrosis

57

[diagnosis]

proliferative disorder of dendritic cells in skin, presence of birbeck granules, presence of racket shaped granules

langerhands histiocytosis

58

[diagnosis]

birbeck granules, pentalaminar racket-shaped granules

langerhans histiocytosis