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Flashcards in breast Deck (51)
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1

painful breast is suggestive of ___ lesion

(benign/malignant)

benign

2

would you suspect cancer of the breast when the nipple discharge is spontaneous and unilateral?

yes

3

most common bacteriologic cause of acute mastitis

S. aureus

4

[diagnosis]

mimic cancer, history of breast trauma

Histo: hemorrhagic, liquefactive fat necrosis with neutrophils and macrophages

fat necrosis

5

[benign or malignant?]

Benign ductal cells
Myoepithelial cells present

benign

6

[diagnosis]

malignant ductal cells
present myoepithelial cells

DCIS

7

[diagnosis]

malignant ductal cells
absent myoepithelial cells
negative p63

invasive CA

8

[diagnosis: proliferative disease without atypia]

> 2 layers of cells in aduct
distorted lumina at periphery
mimics DCIS

Epithelial hyperplasia

9

[diagnosis: proliferative disease without atypia]

solid cords or double strands of cells in a densely fibrotic stroma

closely mimics carcinoma; inner ducts are compressed

sclerosing adenosis

10

[diagnosis: proliferative disease without atypia]

papillary fronds with fibrovascular cores growing in a dilated duct

present myoepithelial layer

papilloma

11

[diagnosis: proliferative disease without atypia]

combination of epithelial hyperplasia, sclerosing adenosis and papilloma

central nidus of entrapped glands in a hyalinized stroma

mimics cancer

complex sclerosing lesion

12

[diagnosis: proliferative disease with atypia]

DCIS without full duct involvement
cribiform pattern (cookie cutter appearance)

atypical ductal hyperplasia

13

[diagnosis: proliferative disease with atypia]

LCIS but less than 50% involvement of acini in a lobule; loss of E-cadherin

Atypical lobular hyperplasia

14

most common non-skin malignancy in women

breast CA

15

2nd to lung CA in causing deaths in women

breast CA

16

BRCA 1 is located in what chroomosome?

Ch 17

17

BRCA 2 is located in what chroomosome?

Ch 13

18

the duct system of that breast that is hormonally responsive

terminal duct-lobular unit

19

site in the breast where invasive breast CA arise

terminal duct-lobular unit

20

[diagnosis: cancer or not CA?]

small, irregular, numerous, clustered calcification

CA

21

[diagnosis: comedo vs non comedo DCIS]

high grade nuclei, central necrosis

comedo DCIS

22

[diagnosis: comedo vs non comedo DCIS]

variable nuclear grade and architectural pattern

non comedo DCIS

23

[diagnosis: comedo vs non comedo DCIS]

ducts filled with cells with high grade nuclear atypia, central necrosis

comedo

24

[diagnosis: comedo vs non comedo DCIS]

ducts completely filled with cell, appearing as solid nets

non-comedo, solid

25

[diagnosis: comedo vs non comedo DCIS]

ducts filled with cells with secondary lumina

non-comedo, cribiform

26

[diagnosis: comedo vs non comedo DCIS]

bulbous projections WITHOUT fibrovascular cores

non-comedo, micropapillary

27

[diagnosis: comedo vs non comedo DCIS]

papillary fronds WITH fibrovascular cores but NO myoepithelial layer in fronds

papillary

28

[diagnosis: CA]

monomorphic cellular appearance, distinct cytoplasmic borders, pale cytoplasm, round nuclei, absent streaming, CK5 (+), CK 6 (-), ER (+), diffuse

DCIS

29

[diagnosis: CA]

heterogenous appearance, indistinct borders, eosinophilic cytoplasm, oval nuclei, present streaming, CK5 (+) CK6 (+), ER (+), mosaic

epithelial hyperplasia

30

[diagnosis: CA]

unilateral eruption with a scale crust, pruritic, malignant cell reaches the ductal cell without violating the basement membrane

paget cells

31

[diagnosis: CA

intact basement membrane, no disruption of lobules, absent necrosis, nipple of the skin not involved, ER(+), PR(+), HER2(-)

LCIS

32

most common type of invasive carcinoma of the breast

invasive breast CA, no special type

33

[diagnosis: infiltrating carcinoma]

in situ with absence of myoepithelial layer, haphazarly disposed cells with desmoplasia

invasive breast CA, no special type

34

[diagnosis: infiltrating carcinoma]

E-cadherin loss, ER/PR (+), HER2 (-), little desmoplasia, indian file/ dyscohesive infiltrating tumor cells in single file

mucin (+)

invasive lobular carcinoma

35

[diagnosis: infiltrating carcinoma]

clusters of small islands of tumor cells floating in pools of extracellular mucin, low atypia

ER/PR(+), HER2 (-)

mucinous (colloid) carcinoma

36

[diagnosis: infiltrating carcinoma]

syncitium-like solid sheets of large cells with pleomorphic nuclei and prominent nucleoli, increased mitosis, lymphoplasmatic infiltrates, pushing borders

ER(-) HER2(-)

medullary carcinoma

37

[diagnosis: infiltrating carcinoma]

extensive invation and proliferation within lymphatic channels, presents as swelling that can mimics non-neoplastic inflammatory disorder

inflammatory CA

38

this test is done to confirm positivity to HER2 in cases of equivocal result

FISH

fluorescence in situ hybridization

39

[diagnosis: drug treatment for this subtype/molecular subtype]

ER(+)
Her2(-)
Ki67 low

Luminal A, tamoxifen

40

[diagnosis: drug treatment for this subtype/molecular subtype]

ER(+)
Her2(-)
Ki67 high

Luminal A, tamoxifen

41

[diagnosis: drug treatment for this subtype/molecular subtype]

ER(+/-)
PR(+/-)
Her2(+)
Ki67 high

Her 2 enriched, Trastuzumab

42

[diagnosis: drug treatment for this subtypemolecular subtype]
in study
ER(-)
Her2(-)
Ki67 high

Basal

43

most common benign tumor of the female breast

fibroadenoma

44

[diagnosis: stromal tumor]

older females, larger breast mass

stromal overgrowth, infiltrative boarders, high cellularity, high mitosis, nuclear pleomorphism, leaf-like projections

phyllodes tumor

45

[diagnosis: type of phyllodes tumor]

Well defined borders, fibroblastic appearance, little to mild atypia, <5 mitoses/10HPF, no stromal overgrowth

benign phyllodes tumor

46

[diagnosis: type of phyllodes tumor]

focally infiltrative borders, moderate cellularity, moderate atypia, 5-9 mitoses/10HPF, no stromal overgrowth or focal stroma

borderline phyllodes tumor

47

[diagnosis: type of phyllodes tumor]

infiltrative borders, high cellularity, marked atypia, >/10 mitoses/10HPF, with stromal overgrowth

malignant phyllodes

48

[diagnosis: type of phyllodes tumor]

metaplastic elements containing bone, skeletal, cartilage tissues

malignant phyllodes

49

[diagnosis: type of phyllodes tumor]

4 LPO field shows only stromal component

malignant phyllodes

50

[diagnosis: stromal tumors]

young female, relatively smaller breast mass

stromal proliferation = epithelial lesion, lesser stromal cellularity, not atypia, no mitosis

fibroadenoma

51

in gynecomastia, the duct lining undergoes ___ (hypertrophy/hyperplasia)

hyperplasia