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Flashcards in breast Deck (51)
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1

painful breast is suggestive of ___ lesion

(benign/malignant)

benign

2

would you suspect cancer of the breast when the nipple discharge is spontaneous and unilateral?

yes

3

most common bacteriologic cause of acute mastitis

S. aureus

4

[diagnosis]

mimic cancer, history of breast trauma

Histo: hemorrhagic, liquefactive fat necrosis with neutrophils and macrophages

fat necrosis

5

[benign or malignant?]

Benign ductal cells
Myoepithelial cells present

benign

6

[diagnosis]

malignant ductal cells
present myoepithelial cells

DCIS

7

[diagnosis]

malignant ductal cells
absent myoepithelial cells
negative p63

invasive CA

8

[diagnosis: proliferative disease without atypia]

> 2 layers of cells in aduct
distorted lumina at periphery
mimics DCIS

Epithelial hyperplasia

9

[diagnosis: proliferative disease without atypia]

solid cords or double strands of cells in a densely fibrotic stroma

closely mimics carcinoma; inner ducts are compressed

sclerosing adenosis

10

[diagnosis: proliferative disease without atypia]

papillary fronds with fibrovascular cores growing in a dilated duct

present myoepithelial layer

papilloma

11

[diagnosis: proliferative disease without atypia]

combination of epithelial hyperplasia, sclerosing adenosis and papilloma

central nidus of entrapped glands in a hyalinized stroma

mimics cancer

complex sclerosing lesion

12

[diagnosis: proliferative disease with atypia]

DCIS without full duct involvement
cribiform pattern (cookie cutter appearance)

atypical ductal hyperplasia

13

[diagnosis: proliferative disease with atypia]

LCIS but less than 50% involvement of acini in a lobule; loss of E-cadherin

Atypical lobular hyperplasia

14

most common non-skin malignancy in women

breast CA

15

2nd to lung CA in causing deaths in women

breast CA

16

BRCA 1 is located in what chroomosome?

Ch 17

17

BRCA 2 is located in what chroomosome?

Ch 13

18

the duct system of that breast that is hormonally responsive

terminal duct-lobular unit

19

site in the breast where invasive breast CA arise

terminal duct-lobular unit

20

[diagnosis: cancer or not CA?]

small, irregular, numerous, clustered calcification

CA

21

[diagnosis: comedo vs non comedo DCIS]

high grade nuclei, central necrosis

comedo DCIS

22

[diagnosis: comedo vs non comedo DCIS]

variable nuclear grade and architectural pattern

non comedo DCIS

23

[diagnosis: comedo vs non comedo DCIS]

ducts filled with cells with high grade nuclear atypia, central necrosis

comedo

24

[diagnosis: comedo vs non comedo DCIS]

ducts completely filled with cell, appearing as solid nets

non-comedo, solid

25

[diagnosis: comedo vs non comedo DCIS]

ducts filled with cells with secondary lumina

non-comedo, cribiform

26

[diagnosis: comedo vs non comedo DCIS]

bulbous projections WITHOUT fibrovascular cores

non-comedo, micropapillary

27

[diagnosis: comedo vs non comedo DCIS]

papillary fronds WITH fibrovascular cores but NO myoepithelial layer in fronds

papillary

28

[diagnosis: CA]

monomorphic cellular appearance, distinct cytoplasmic borders, pale cytoplasm, round nuclei, absent streaming, CK5 (+), CK 6 (-), ER (+), diffuse

DCIS

29

[diagnosis: CA]

heterogenous appearance, indistinct borders, eosinophilic cytoplasm, oval nuclei, present streaming, CK5 (+) CK6 (+), ER (+), mosaic

epithelial hyperplasia

30

[diagnosis: CA]

unilateral eruption with a scale crust, pruritic, malignant cell reaches the ductal cell without violating the basement membrane

paget cells