Female Genital Tract Pathology Flashcards Preview

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Flashcards in Female Genital Tract Pathology Deck (69)
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1

[diagnosis]

plasma cells in endometrial stroma

chronic endometritis

2

[diagnosis]

lymphocytes or plasma cells in cervical stroma

chronic cervicitis

3

[diagnosis]

pelvic pain, adnexal tenderness, fever, vaginal discharge

PID

4

[diagnosis]

gross: leukoplakia of the vulva

thinning of the epidermis, basal cell degeneration, hyperkeratosis, sclerotic changes of superficial dermis, dermal lymphocytic infiltrate

lichen slerosus

5

[diagnosis]

gross: leukoplakia of the vulva

acanthosis, mitosis, hyperkeratosis, lymphocytic infiltrates

squamous hyperplasia

6

[diagnosis]

failure of mullerian duct fusion, accompanied by uterine didelphys

septate vagina

7

vaginal anomaly associated with DES exposure

septate vagina

8

[diagnosis]

___ cyst

remnant of wolffian or mesonephric duct

gartner duct cyst

9

most common primary vulvar CA

squamois cell CA

10

[diagnosis]

patient 4 years old, gross presence of grape-like clusters

sarcoma botryoides

11

___ term for small, with oval nuclei and tennis racket like appearance with or without striations in sarcoma botryoides

embryonal rhabdomyoblast

12

[diagnosis]

fibromyxoid stroma, lined by endocervical type epithelium, usually with inflammation

endocervical polyp

13

[HPV]

Infects: _____ (mature/immature)

Replicates in: ______ (mature/immature)

Infects immature cells
replicates in mature cells

14

[HPV]

E___ inactivates Rb leading to cell proliferation

E7

15

[HPV]

E___ inactivates p53 leading to cellular immortality

E6

16

[diagnosis: CIN]

nuclear atypia with cytoplasmic "halos", confined to lower third of epithelium

LSIL

17

[diagnosis: CIN]

nuclear atypia with cytoplasmic "halos", expansion to upper two-thirds of epithelium

HSIL

18

[diagnosis]

CIN + invasion beyond the basement membrane

cervical CA

19

[diagnosis]

infertility, dysmenorrhea, chronic pelvic pain

Gross: subserosal red-blue to yellow brown nodules on sites of involvement, ovaries may be converted to cyst

Histology: endometrial glands and stroma

Cyst lining: hemosiderin-laden macrophages in old hemorrhage, fibrosis

endometriosis

20

[diagnosis]

chocolate cyst

endometriosis

21

[diagnosis]

menometorrhagia, colicky dysmenorrhea, dyspareunia, premenstrual pelvic pain

gross: symmetrically enlarged corpus, with multiple blood lakes within the myometrium

histo: (+) endometrial stroma, with or without glands, within the myometrium, separated from the decidual basalis by 2 to 3 mm

adenomyosis

22

[diagnosis]

due to retrograde menstruation

endometriosis

23

[diagnosis]

exophytic mass that project into endometrial cavity, clinically silent AUB, seen in patient on tamoxifen

endometrial polyp

24

[diagnosis]

precursor to endometrial CA type I, important cause of AUB

endometrial hyperplasia

25

most common malignancy of the female genital tract

endometrial carcinoma

26

[diagnosis]

postmenopausal bleeding, increased exposure to estrogen

endometrial CA

27

inactivation of this tumor suppressor gene can lead to atypical hyperplasia leading to endometrial CA

PTEN

28

precursor lesion to Type II endometrial CA

serous endometrial intraepithelial CA

29

a tumor suppressor gene that is associated with endomterial CA microsatellite instability

KRAS

30

[diagnosis: endometrial CA type]

localized polypoid tumor, has three grades, glandular and solid; mild to moderate atypia

type I endometriod

31

[diagnosis: endometrial CA type]

atrophic uterus with large bulky, infiltrative mass

presence of papillary fronds, marked atypia

Type II serous

32

most common tumor in women

leiomyoma

33

[diagnosis]

not encapsulated, well circumscribed, grayish-white tumor, intramural

absent necrosis, scarce to low mitotic figure, absent to mild atypia

leiomyoma

34

[diagnosis]

bulky, fleshy mass invading the uterine wall or polypoid mass projecting to the uterine lumen

atypia is present, necrosis is present

leiomyosarcoma

35

[diagnosis]

uterine mass wherein the glands are benign, stroma is malignant

adenosarcoma

36

[diagnosis]

uterine mass wherein the glands are malignant, stroma are malignant

malignant mixed mullerian tumor

37

fallopian tube epithelium that is related to high-grade serous carcinoma

serous tubal intraepithelial carcinoma

38

[diagnosis: ovarian cyst]

ovarian cyst 2cm

cystic follicle

39

[diagnosis: ovarian cyst]

ovarian cyst > 2cm

follicle cyst

40

rupture of this ovarian cyst can lead to peritoneal reaction

luteal cyst

41

Stein-Leventhal Syndrome is also called

PCOS

42

most common ovarian tumors

mullerian epithelium (germ cell, sex cord-stromal, metastatic)

43

most common surface epithelial tumors of the ovary

serous

44

tumor marker for ovarian CA used to monitor recurrence and progression

CA 125

45

presence of _____ in surface epithelial tumors distinguish borderline from benign tumors

stromal invasion

46

presence of ____ in surface epithelial tumors distinguishes borderline tumors from benign tumors

atypia and complex architecture

47

[diagnosis: type of serous ovarian tumor]

mutation of TP53, KRAS, BRAF

Mucinous, low grade

Type I

48

[diagnosis: type of serous ovarian tumor]

mutation of TP53, BRCA, PIK3CA

Serous, high grade

Type II

49

[diagnosis: ovarian tumor]

non-ciliated, tall columnar, usually unilateral, can produce large mass

associated with pseudomyxoma peritoni

mucinous tumor

50

most common site of mucinous tumor in pseudmyxoma peritoni

appendix

51

most common germ cell tumor

mature cystic teratoma

52

[diagnosis]

presence of tubular glands resembling benign or malignant endometrium; squamous differentiation

endometriod tumors

53

most common MALIGNANT germ cell tumor

dysgerminoma

54

[diagnosis: germ cell tumor]

nest of large, vesicular cells with clear cytoplasm, centrally located nuclei with lymphocytic infiltration

tumor marker: KIT

dysgerminoma

55

[diagnosis: germ cell tumor]

central blood vessels enveloped by tumor cells within a space lined by tumor cells (+) hyaline bodies

Tumor marker: AFP

Yolk sac tumor/endodermal sinus tumor

56

[diagnosis: germ cell tumor]

schiller-duval bodies

Yolk sac tumor/endodermal sinus tumor

57

[diagnosis: germ cell tumor]

tumor marker: HCG

ovarian choriocarcinoma

58

[diagnosis: sex-cord stromal tumors]

hyperestrenism,

presence of call exner bodies

Tumor marker: estrogen, inhibin

granulosa cell tumor

59

[diagnosis: sex-cord stromal tumors]

defemination, virilization

tumor marker: androgen

Sertoli-leydig cell tumor

60

[diagnosis: sex-cord stromal tumors]

mass effect, associated with Meigs syndrome

fibroblast-like cells or plump spindle cells

tumor marker: none

Thecoma/Fibroma

61

[diagnosis]

Hydrothorax
ascites
ovarian tumor

Meigs Syndrome

62

[diagnosis: sex-cord stromal tumors]

small, cuboidal to polygona cells in sheets, cords, may recapitulate with central acidophilic material

granulosa cell tumor

63

[diagnosis]

cystic swelling of the chorionic villi with trophoblastic invasion

Hydatidiform mole

64

[diagnosis: H. mole]

46XX, most common

complete mole

65

[diagnosis: H. mole]

69XXX or 69 XXY

partial mole

66

[diagnosis: H. mole]

missed abortion, small for dates uterine size, initial hCg <100,000

embyo-fetus, Amnion, fetal erythrocyte present, focal villous edema, mild trophoblastic atypia

partial mole

67

[diagnosis: H. mole]

molar gestation, large for dates uterine size, initial hCg >100,000, absent fetal parts, absent amnion

widespread villous edema, marked trophoblastic proliferation and atypia

complete mole

68

[diagnosis]

proliferation of syncitiotrophoblast and cytotrophoblast without villi formation

rapidly invasive, metastasizing but responsive to chemo

choriocarcinoma

69

[diagnosis]

proliferation of syncitiotrophoblast and cytotrophoblast WITH villi formation

rapidly invasive, metastasizing but responsive to chemo

invasive mole