Female Genital Tract Pathology Flashcards Preview

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Flashcards in Female Genital Tract Pathology Deck (69)
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1

[diagnosis]

plasma cells in endometrial stroma

chronic endometritis

2

[diagnosis]

lymphocytes or plasma cells in cervical stroma

chronic cervicitis

3

[diagnosis]

pelvic pain, adnexal tenderness, fever, vaginal discharge

PID

4

[diagnosis]

gross: leukoplakia of the vulva

thinning of the epidermis, basal cell degeneration, hyperkeratosis, sclerotic changes of superficial dermis, dermal lymphocytic infiltrate

lichen slerosus

5

[diagnosis]

gross: leukoplakia of the vulva

acanthosis, mitosis, hyperkeratosis, lymphocytic infiltrates

squamous hyperplasia

6

[diagnosis]

failure of mullerian duct fusion, accompanied by uterine didelphys

septate vagina

7

vaginal anomaly associated with DES exposure

septate vagina

8

[diagnosis]

___ cyst

remnant of wolffian or mesonephric duct

gartner duct cyst

9

most common primary vulvar CA

squamois cell CA

10

[diagnosis]

patient 4 years old, gross presence of grape-like clusters

sarcoma botryoides

11

___ term for small, with oval nuclei and tennis racket like appearance with or without striations in sarcoma botryoides

embryonal rhabdomyoblast

12

[diagnosis]

fibromyxoid stroma, lined by endocervical type epithelium, usually with inflammation

endocervical polyp

13

[HPV]

Infects: _____ (mature/immature)

Replicates in: ______ (mature/immature)

Infects immature cells
replicates in mature cells

14

[HPV]

E___ inactivates Rb leading to cell proliferation

E7

15

[HPV]

E___ inactivates p53 leading to cellular immortality

E6

16

[diagnosis: CIN]

nuclear atypia with cytoplasmic "halos", confined to lower third of epithelium

LSIL

17

[diagnosis: CIN]

nuclear atypia with cytoplasmic "halos", expansion to upper two-thirds of epithelium

HSIL

18

[diagnosis]

CIN + invasion beyond the basement membrane

cervical CA

19

[diagnosis]

infertility, dysmenorrhea, chronic pelvic pain

Gross: subserosal red-blue to yellow brown nodules on sites of involvement, ovaries may be converted to cyst

Histology: endometrial glands and stroma

Cyst lining: hemosiderin-laden macrophages in old hemorrhage, fibrosis

endometriosis

20

[diagnosis]

chocolate cyst

endometriosis

21

[diagnosis]

menometorrhagia, colicky dysmenorrhea, dyspareunia, premenstrual pelvic pain

gross: symmetrically enlarged corpus, with multiple blood lakes within the myometrium

histo: (+) endometrial stroma, with or without glands, within the myometrium, separated from the decidual basalis by 2 to 3 mm

adenomyosis

22

[diagnosis]

due to retrograde menstruation

endometriosis

23

[diagnosis]

exophytic mass that project into endometrial cavity, clinically silent AUB, seen in patient on tamoxifen

endometrial polyp

24

[diagnosis]

precursor to endometrial CA type I, important cause of AUB

endometrial hyperplasia

25

most common malignancy of the female genital tract

endometrial carcinoma

26

[diagnosis]

postmenopausal bleeding, increased exposure to estrogen

endometrial CA

27

inactivation of this tumor suppressor gene can lead to atypical hyperplasia leading to endometrial CA

PTEN

28

precursor lesion to Type II endometrial CA

serous endometrial intraepithelial CA

29

a tumor suppressor gene that is associated with endomterial CA microsatellite instability

KRAS

30

[diagnosis: endometrial CA type]

localized polypoid tumor, has three grades, glandular and solid; mild to moderate atypia

type I endometriod