Red Blood Cell and Bleeding Disorders Flashcards Preview

Question 1

1

ratio of the volume of erythrocytes to that of whole blood

Answer

hematocrit

Question 2

2

average volume of red cells

MCV

Answer

MCV

macrocytic, microcytic, normocytic

Answer

MCH

hypochromic, normchromic

Answer

Hereditary spherocytosis

Answer

G6PD deficiency

Answer

Sickle cell anemia

Answer

Sickle cell anemia

Answer

sickle cell anemia

Answer

beta thalassemia

Answer

Paroxysmal Nocturnal Hemoglobinuria

Answer

warm agglutinin

Answer

warm agglutinin

Answer

Cold agglutinin disease

Answer

cold agglutinins

Answer

megaloblastic anemia

Answer

megaloblastic anemia

Answer

Vitamin B12

Answer

Anemia of chronic disease

Answer

Aplastic anemia

Answer

pure red cell aplasia

Answer

parvovirus

Answer

myelopthisic anemia

Answer

polycythemia vera

Answer

Chronic ITP

Answer

bernard-soulier disease

Answer

glanzman thrombastenia

Answer

von willebrand disease

Answer

von willebrand

Answer

hemophilia

Answer

hemophilia

Answer

Hemolytic Uremic Syndrome

normal ADAMTS13 level

Answer

Thrombotic Thrombocytopenic Purpura

Answer

Kasabach-Merritt Syndrome)

Answer

Ehler-Danlos

Answer

ITP or TTP

Answer

Bernard soulier

Answer

glanzmann thrombastenia

Answer

vWF disease

Answer

hemophilia

Answer

vitamin K deficiency

Answer

Acute hemolytic transfusion reactions

Question 3

3

weight of Hgb of the average red cell

MCH

Question 4

4

Average concentration of hemoglobin in a given volume of packed red cell

MCHC

Question 5

5

Reflects variability in red cell and shape

RDW

Question 6

6

[red cell index]

___ = Hgb/3

Hct

Question 7

7

[red cell index]

____ = RBC x 3

Hgb

Question 8

8

[red cell index]

___ = Hct/RBC

Question 9

9

[red cell index]

_____ = Hgb/RBC

Question 10

10

[red cell index]

____ = (Hgb/Hct) x 100

MCHC

Question 11

11

[diagnosis]

increased MCHC, RBC is round, without central pallor

intrinsic type of hemolysis, extravascular site of hemolysis

Question 12

12

[diagnosis]
Heins bodies, Bite Cells, Protective against malaria

intrinsic type of hemolysis, intravascular and extravascular site of hemolysis

Question 13

13

[diagnosis]
presence of codocytes (dehydrated RBCs), drepanocytes, protective against malaria, extramedullary hematopoeisis

intrinsic type of hemolysis, extravascular site of hemolysis

Question 14

14

[diagnosis]

E6V mutation; RBC changes shape in low pH and low oxygen tension

Question 15

15

Hydroxyurea is used in treating sickle cell anemia. This increasesthe ____

HbF

Question 16

16

[diagnosis]

symptomatic infants starting 5-6 months of age, acute splenomegaly, painful vaso-occlusive crisis, causes autosplenectomy

Question 17

17

[diagnosis]

infants become symptomatic at 6-9 months of age, crew-cut appearance

microcytic, hypochromic anemia, intrinsic type, extravascular hemolysis

Question 18

18

[diagnosis]

deficiency in complement regulatory proteins CD55, CD59, C8 binding protein

increased complement mediated lysis (C5-9)

less blood pH at night, increases complement activity

Question 19

19

most common immunohemolytic anema

Question 20

20

[type of immunohemolytic anemia]

IgG

Associated with SLE nad drugs

Question 21

21

[type of immunohemolytic anemias]

IgM mediated
associated with mycoplasmal infections and infectious mononucleosis

prefers fingers, toes, aears

Question 22

22

[type of agglutinin]

low RBC, increased MCV, increased MCHC

PBS: red cell agglutination

Question 23

23

[hypoproliferative anemia]

impaired nuclear maturation with normal cytoplasmic maturation (nuclear-cytoplasmic asynchrony); abnormally large erythroid precursors and red cells; megakaryocyte is large with bizarre, multilobate nuclei

Question 24

24

[diagnosis]

anisocytosis, poikilocytosis, giant metamyelocytesa nd band forms (>/ 5 lobes)

megakaryocyte: large, with bizarre, multilobate

Question 25

25

vitamin deficiency associated with neurologic manifestations (degeneration of posterolateral cord tracts)

Question 26

26

[type of anemia]

microcytic, hypochromic, increased RDW

low serum Fe, low ferritin, increased TIBC

IDA

Question 27

27

[type of anemia]
low serum iron, high ferritin, low transferrin

Question 28

28

[diagnosis]

Normocytic, normochromic
BMA: hypocellular, dry tap

Question 29

29

[diagnosis]

normocytic, normochromic
BMA: virtually absent erythroblasts in marrow, normal granulo- and thrombopoietic elements

Question 30

30

virus that preferentially infect erythroid precurosrs

Question 31

31

[diagnosis]

space occupying lesion that replace normal marrow elements; tear-drop shaped cells

Question 32

32

[diagnosis]

abnormally high red cell county with increase in hemoglobin;

Question 33

33

deranged bleeding ime means there is a defect in platelet _____

function

Question 34

34

[diagnosis]

usually seen in adults 40y/o, associated with SLE, CLL, HIV; antibodies against gp IIb-IIIa, gbIb-IX

BMA: increased megakaroyocytes
PBS: large platelets

Spleen congestion, follicular hyperplasia

Treated with glucocorticoids

Question 35

35

[diagnosis]

usually seen in children associated with post-viral illness; antibodies against gp IIb-IIIa, gbIb-IX

BMA: increased megakaroyocytes
PBS: large platelets

Spleen congestion, follicular hyperplasia

self limited`

acute itp

Question 36

36

[diagnosis]

defect in platelet adhesion due to deficiency in gpIb-IX

Question 37

37

[diagnosis]

defect in platelet aggregation due to deficiency in gpIIb-IIIa

Question 38

38

most common inherited bleeding disorder

Question 39

39

[diagnosis]

platelet count: normal
bleeding time: impaired

Question 40

40

[diagnosis]

platelet count: normal
bleeding time: normal

Question 41

41

most common hereditary syndrome with life threatening bleeding

Question 42

42

[diagnosis]

1. microangiopathic hemolytic anemia
2. Thrombocytopenia
3. Renal failure

Question 43

43

[diagnosis]

1. microangiopathic hemolytic anemia
2. Thrombocytopenia
3. Renal failure
4. Fever
5. Neurologic manifestation

Question 44

44

[diagnosis]

ADAMTS13 is decreased

TTP

Question 45

45

this is a metalloproteinase of vWF that is normal in HUS

ADAMTS13

Question 46

46

___ syndrome wherein a thrombi lodged to a gian hemangioma (DIC-related)

Question 47

47

[diagnosis]

low PC, prolonged bleeding time, prolonged PT, prolonged aPTT

DIC

Question 48

48

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: normal
PT: normal
PTT: normal

Question 49

49

[diagnosis, bleeding disorders]

PC: low
Bleeding time: prolonged
PT: normal
PTT: normal

Question 50

50

[diagnosis, bleeding disorders]

PC: low
Bleeding time: prolonged
PT: normal
PTT: normal

Question 51

51

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: prolonged
PT: normal
PTT: normal

Question 52

52

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: prolonged
PT: normal
PTT: prolonged

Question 53

53

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: normal
PT: normal
PTT: prolonged

Question 54

54

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: normal
PT: prolonged
PTT: prolonged

Question 55

55

[diagnosis, bleeding disorders]

PC: low
Bleeding time: prolonged
PT: prolonged
PTT: prolonged

DIC

Question 56

56

[type of transfusion reaction]

presence of preformed IgM to donor red cell antigen

Question 57

57

[type of transfusion reaction]

IgG to red cell antigen the patient was previously sensitized to

Delayed

Question 58

58

Brainscape's Knowledge GenomeTM

Red Blood Cell and Bleeding Disorders Flashcards Preview

Pathology > Red Blood Cell and Bleeding Disorders > Flashcards

ratio of the volume of erythrocytes to that of whole blood

hematocrit

average volume of red cells

MCV

weight of Hgb of the average red cell

MCH

Average concentration of hemoglobin in a given volume of packed red cell

MCHC

Reflects variability in red cell and shape

RDW

[red cell index]___ = Hgb/3

Hct

[red cell index]____ = RBC x 3

Hgb

[red cell index]___ = Hct/RBC

MCVmacrocytic, microcytic, normocytic

[red cell index]_____ = Hgb/RBC

MCHhypochromic, normchromic

[red cell index]____ = (Hgb/Hct) x 100

MCHC

[diagnosis]increased MCHC, RBC is round, without central pallorintrinsic type of hemolysis, extravascular site of hemolysis

Hereditary spherocytosis

[diagnosis]Heins bodies, Bite Cells, Protective against malariaintrinsic type of hemolysis, intravascular and extravascular site of hemolysis

G6PD deficiency

[diagnosis]presence of codocytes (dehydrated RBCs), drepanocytes, protective against malaria, extramedullary hematopoeisisintrinsic type of hemolysis, extravascular site of hemolysis

Sickle cell anemia

[diagnosis]E6V mutation; RBC changes shape in low pH and low oxygen tension

Sickle cell anemia

Hydroxyurea is used in treating sickle cell anemia. This increasesthe ____

HbF

[diagnosis]symptomatic infants starting 5-6 months of age, acute splenomegaly, painful vaso-occlusive crisis, causes autosplenectomy

sickle cell anemia

[diagnosis]infants become symptomatic at 6-9 months of age, crew-cut appearancemicrocytic, hypochromic anemia, intrinsic type, extravascular hemolysis

beta thalassemia

[diagnosis]deficiency in complement regulatory proteins CD55, CD59, C8 binding proteinincreased complement mediated lysis (C5-9)less blood pH at night, increases complement activity

Paroxysmal Nocturnal Hemoglobinuria

most common immunohemolytic anema

warm agglutinin

[type of immunohemolytic anemia]IgGAssociated with SLE nad drugs

warm agglutinin

[type of immunohemolytic anemias]IgM mediatedassociated with mycoplasmal infections and infectious mononucleosisprefers fingers, toes, aears

Cold agglutinin disease

[type of agglutinin]low RBC, increased MCV, increased MCHCPBS: red cell agglutination

cold agglutinins

[hypoproliferative anemia]impaired nuclear maturation with normal cytoplasmic maturation (nuclear-cytoplasmic asynchrony); abnormally large erythroid precursors and red cells; megakaryocyte is large with bizarre, multilobate nuclei

megaloblastic anemia

[diagnosis]anisocytosis, poikilocytosis, giant metamyelocytesa nd band forms (>/ 5 lobes)megakaryocyte: large, with bizarre, multilobate

megaloblastic anemia

vitamin deficiency associated with neurologic manifestations (degeneration of posterolateral cord tracts)

Vitamin B12

[type of anemia]microcytic, hypochromic, increased RDWlow serum Fe, low ferritin, increased TIBC

IDA

[type of anemia]low serum iron, high ferritin, low transferrin

Anemia of chronic disease

[diagnosis]Normocytic, normochromicBMA: hypocellular, dry tap

Aplastic anemia

[diagnosis]normocytic, normochromicBMA: virtually absent erythroblasts in marrow, normal granulo- and thrombopoietic elements

pure red cell aplasia

virus that preferentially infect erythroid precurosrs

parvovirus

[diagnosis]space occupying lesion that replace normal marrow elements; tear-drop shaped cells

myelopthisic anemia

[diagnosis]abnormally high red cell county with increase in hemoglobin;

polycythemia vera

deranged bleeding ime means there is a defect in platelet _____

function

[diagnosis]usually seen in adults 40y/o, associated with SLE, CLL, HIV; antibodies against gp IIb-IIIa, gbIb-IXBMA: increased megakaroyocytesPBS: large plateletsSpleen congestion, follicular hyperplasiaTreated with glucocorticoids

Chronic ITP

[diagnosis]usually seen in children associated with post-viral illness; antibodies against gp IIb-IIIa, gbIb-IXBMA: increased megakaroyocytesPBS: large plateletsSpleen congestion, follicular hyperplasiaself limited`

acute itp

[diagnosis]defect in platelet adhesion due to deficiency in gpIb-IX

bernard-soulier disease

[diagnosis]defect in platelet aggregation due to deficiency in gpIIb-IIIa

glanzman thrombastenia

most common inherited bleeding disorder

von willebrand disease

[diagnosis]platelet count: normalbleeding time: impaired

Brainscape's Knowledge Genome^TM

[red cell index]

___ = Hgb/3

[red cell index]

____ = RBC x 3

[red cell index]

___ = Hct/RBC

MCV

macrocytic, microcytic, normocytic

[red cell index]

_____ = Hgb/RBC

MCH

hypochromic, normchromic

[red cell index]

____ = (Hgb/Hct) x 100

[diagnosis]

increased MCHC, RBC is round, without central pallor

intrinsic type of hemolysis, extravascular site of hemolysis

[diagnosis]
Heins bodies, Bite Cells, Protective against malaria

intrinsic type of hemolysis, intravascular and extravascular site of hemolysis

[diagnosis]
presence of codocytes (dehydrated RBCs), drepanocytes, protective against malaria, extramedullary hematopoeisis

intrinsic type of hemolysis, extravascular site of hemolysis

[diagnosis]

E6V mutation; RBC changes shape in low pH and low oxygen tension

[diagnosis]

symptomatic infants starting 5-6 months of age, acute splenomegaly, painful vaso-occlusive crisis, causes autosplenectomy

[diagnosis]

infants become symptomatic at 6-9 months of age, crew-cut appearance

microcytic, hypochromic anemia, intrinsic type, extravascular hemolysis

[diagnosis]

deficiency in complement regulatory proteins CD55, CD59, C8 binding protein

increased complement mediated lysis (C5-9)

less blood pH at night, increases complement activity

[type of immunohemolytic anemia]

IgG

Associated with SLE nad drugs

[type of immunohemolytic anemias]

IgM mediated
associated with mycoplasmal infections and infectious mononucleosis

prefers fingers, toes, aears

[type of agglutinin]

low RBC, increased MCV, increased MCHC

PBS: red cell agglutination

[hypoproliferative anemia]

impaired nuclear maturation with normal cytoplasmic maturation (nuclear-cytoplasmic asynchrony); abnormally large erythroid precursors and red cells; megakaryocyte is large with bizarre, multilobate nuclei

[diagnosis]

anisocytosis, poikilocytosis, giant metamyelocytesa nd band forms (>/ 5 lobes)

megakaryocyte: large, with bizarre, multilobate

[type of anemia]

microcytic, hypochromic, increased RDW

low serum Fe, low ferritin, increased TIBC

[type of anemia]
low serum iron, high ferritin, low transferrin

[diagnosis]

Normocytic, normochromic
BMA: hypocellular, dry tap

[diagnosis]

normocytic, normochromic
BMA: virtually absent erythroblasts in marrow, normal granulo- and thrombopoietic elements

[diagnosis]

space occupying lesion that replace normal marrow elements; tear-drop shaped cells

[diagnosis]

abnormally high red cell county with increase in hemoglobin;

[diagnosis]

usually seen in adults 40y/o, associated with SLE, CLL, HIV; antibodies against gp IIb-IIIa, gbIb-IX

BMA: increased megakaroyocytes
PBS: large platelets

Spleen congestion, follicular hyperplasia

Treated with glucocorticoids

[diagnosis]

usually seen in children associated with post-viral illness; antibodies against gp IIb-IIIa, gbIb-IX

BMA: increased megakaroyocytes
PBS: large platelets

Spleen congestion, follicular hyperplasia

self limited`

[diagnosis]

defect in platelet adhesion due to deficiency in gpIb-IX

[diagnosis]

defect in platelet aggregation due to deficiency in gpIIb-IIIa

[diagnosis]

platelet count: normal
bleeding time: impaired

[diagnosis]

platelet count: normal
bleeding time: normal

[diagnosis]

1. microangiopathic hemolytic anemia
2. Thrombocytopenia
3. Renal failure

Hemolytic Uremic Syndrome

normal ADAMTS13 level

[diagnosis]

1. microangiopathic hemolytic anemia
2. Thrombocytopenia
3. Renal failure
4. Fever
5. Neurologic manifestation

[diagnosis]

ADAMTS13 is decreased

[diagnosis]

low PC, prolonged bleeding time, prolonged PT, prolonged aPTT

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: normal
PT: normal
PTT: normal

[diagnosis, bleeding disorders]

PC: low
Bleeding time: prolonged
PT: normal
PTT: normal

[diagnosis, bleeding disorders]

PC: low
Bleeding time: prolonged
PT: normal
PTT: normal

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: prolonged
PT: normal
PTT: normal

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: prolonged
PT: normal
PTT: prolonged

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: normal
PT: normal
PTT: prolonged

[diagnosis, bleeding disorders]

PC: normal
Bleeding time: normal
PT: prolonged
PTT: prolonged

[diagnosis, bleeding disorders]

PC: low
Bleeding time: prolonged
PT: prolonged
PTT: prolonged

[type of transfusion reaction]

presence of preformed IgM to donor red cell antigen

[type of transfusion reaction]

IgG to red cell antigen the patient was previously sensitized to

[type of transfusion reactions]
Activation of PMNs in lung vasculature