Flashcards in Red Blood Cell and Bleeding Disorders Deck (58)
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1
ratio of the volume of erythrocytes to that of whole blood
hematocrit
2
average volume of red cells
MCV
3
weight of Hgb of the average red cell
MCH
4
Average concentration of hemoglobin in a given volume of packed red cell
MCHC
5
Reflects variability in red cell and shape
RDW
6
[red cell index]
___ = Hgb/3
Hct
7
[red cell index]
____ = RBC x 3
Hgb
8
[red cell index]
___ = Hct/RBC
MCV
macrocytic, microcytic, normocytic
9
[red cell index]
_____ = Hgb/RBC
MCH
hypochromic, normchromic
10
[red cell index]
____ = (Hgb/Hct) x 100
MCHC
11
[diagnosis]
increased MCHC, RBC is round, without central pallor
intrinsic type of hemolysis, extravascular site of hemolysis
Hereditary spherocytosis
12
[diagnosis]
Heins bodies, Bite Cells, Protective against malaria
intrinsic type of hemolysis, intravascular and extravascular site of hemolysis
G6PD deficiency
13
[diagnosis]
presence of codocytes (dehydrated RBCs), drepanocytes, protective against malaria, extramedullary hematopoeisis
intrinsic type of hemolysis, extravascular site of hemolysis
Sickle cell anemia
14
[diagnosis]
E6V mutation; RBC changes shape in low pH and low oxygen tension
Sickle cell anemia
15
Hydroxyurea is used in treating sickle cell anemia. This increasesthe ____
HbF
16
[diagnosis]
symptomatic infants starting 5-6 months of age, acute splenomegaly, painful vaso-occlusive crisis, causes autosplenectomy
sickle cell anemia
17
[diagnosis]
infants become symptomatic at 6-9 months of age, crew-cut appearance
microcytic, hypochromic anemia, intrinsic type, extravascular hemolysis
beta thalassemia
18
[diagnosis]
deficiency in complement regulatory proteins CD55, CD59, C8 binding protein
increased complement mediated lysis (C5-9)
less blood pH at night, increases complement activity
Paroxysmal Nocturnal Hemoglobinuria
19
most common immunohemolytic anema
warm agglutinin
20
[type of immunohemolytic anemia]
IgG
Associated with SLE nad drugs
warm agglutinin
21
[type of immunohemolytic anemias]
IgM mediated
associated with mycoplasmal infections and infectious mononucleosis
prefers fingers, toes, aears
Cold agglutinin disease
22
[type of agglutinin]
low RBC, increased MCV, increased MCHC
PBS: red cell agglutination
cold agglutinins
23
[hypoproliferative anemia]
impaired nuclear maturation with normal cytoplasmic maturation (nuclear-cytoplasmic asynchrony); abnormally large erythroid precursors and red cells; megakaryocyte is large with bizarre, multilobate nuclei
megaloblastic anemia
24
[diagnosis]
anisocytosis, poikilocytosis, giant metamyelocytesa nd band forms (>/ 5 lobes)
megakaryocyte: large, with bizarre, multilobate
megaloblastic anemia
25
vitamin deficiency associated with neurologic manifestations (degeneration of posterolateral cord tracts)
Vitamin B12
26
[type of anemia]
microcytic, hypochromic, increased RDW
low serum Fe, low ferritin, increased TIBC
IDA
27
[type of anemia]
low serum iron, high ferritin, low transferrin
Anemia of chronic disease
28
[diagnosis]
Normocytic, normochromic
BMA: hypocellular, dry tap
Aplastic anemia
29
[diagnosis]
normocytic, normochromic
BMA: virtually absent erythroblasts in marrow, normal granulo- and thrombopoietic elements
pure red cell aplasia
30
