Red Blood Cell and Bleeding Disorders Flashcards Preview

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Flashcards in Red Blood Cell and Bleeding Disorders Deck (58)
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1

ratio of the volume of erythrocytes to that of whole blood

hematocrit

2

average volume of red cells

MCV

3

weight of Hgb of the average red cell

MCH

4

Average concentration of hemoglobin in a given volume of packed red cell

MCHC

5

Reflects variability in red cell and shape

RDW

6

[red cell index]

___ = Hgb/3

Hct

7

[red cell index]

____ = RBC x 3

Hgb

8

[red cell index]

___ = Hct/RBC

MCV

macrocytic, microcytic, normocytic

9

[red cell index]

_____ = Hgb/RBC

MCH

hypochromic, normchromic

10

[red cell index]

____ = (Hgb/Hct) x 100

MCHC

11

[diagnosis]

increased MCHC, RBC is round, without central pallor

intrinsic type of hemolysis, extravascular site of hemolysis

Hereditary spherocytosis

12

[diagnosis]
Heins bodies, Bite Cells, Protective against malaria

intrinsic type of hemolysis, intravascular and extravascular site of hemolysis

G6PD deficiency

13

[diagnosis]
presence of codocytes (dehydrated RBCs), drepanocytes, protective against malaria, extramedullary hematopoeisis

intrinsic type of hemolysis, extravascular site of hemolysis

Sickle cell anemia

14

[diagnosis]

E6V mutation; RBC changes shape in low pH and low oxygen tension

Sickle cell anemia

15

Hydroxyurea is used in treating sickle cell anemia. This increasesthe ____

HbF

16

[diagnosis]

symptomatic infants starting 5-6 months of age, acute splenomegaly, painful vaso-occlusive crisis, causes autosplenectomy

sickle cell anemia

17

[diagnosis]

infants become symptomatic at 6-9 months of age, crew-cut appearance

microcytic, hypochromic anemia, intrinsic type, extravascular hemolysis

beta thalassemia

18

[diagnosis]

deficiency in complement regulatory proteins CD55, CD59, C8 binding protein

increased complement mediated lysis (C5-9)

less blood pH at night, increases complement activity

Paroxysmal Nocturnal Hemoglobinuria

19

most common immunohemolytic anema

warm agglutinin

20

[type of immunohemolytic anemia]

IgG

Associated with SLE nad drugs

warm agglutinin

21

[type of immunohemolytic anemias]

IgM mediated
associated with mycoplasmal infections and infectious mononucleosis

prefers fingers, toes, aears

Cold agglutinin disease

22

[type of agglutinin]

low RBC, increased MCV, increased MCHC

PBS: red cell agglutination

cold agglutinins

23

[hypoproliferative anemia]

impaired nuclear maturation with normal cytoplasmic maturation (nuclear-cytoplasmic asynchrony); abnormally large erythroid precursors and red cells; megakaryocyte is large with bizarre, multilobate nuclei

megaloblastic anemia

24

[diagnosis]

anisocytosis, poikilocytosis, giant metamyelocytesa nd band forms (>/ 5 lobes)

megakaryocyte: large, with bizarre, multilobate

megaloblastic anemia

25

vitamin deficiency associated with neurologic manifestations (degeneration of posterolateral cord tracts)

Vitamin B12

26

[type of anemia]

microcytic, hypochromic, increased RDW

low serum Fe, low ferritin, increased TIBC

IDA

27

[type of anemia]
low serum iron, high ferritin, low transferrin

Anemia of chronic disease

28

[diagnosis]

Normocytic, normochromic
BMA: hypocellular, dry tap

Aplastic anemia

29

[diagnosis]

normocytic, normochromic
BMA: virtually absent erythroblasts in marrow, normal granulo- and thrombopoietic elements

pure red cell aplasia

30

virus that preferentially infect erythroid precurosrs

parvovirus