Endocrine System Pathology Flashcards Preview

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Flashcards in Endocrine System Pathology Deck (104)
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1

sudden onset of neurologic impairment due to a rapidly enlarging adenoma

pituitary apoplexy

2

cut off value to determine micro and macroadenomas

1cm

3

most common cause of hyperpituitarism

prolactin cell adenoma

4

second most common cause of hyperpituitarism

somatotroph adenoma

5

[diagnosis: pituitary cell type]

galactorhea, amenorrhea (in females), seuxal dysfunction, infertility

lactotroph

Hormone: prolactin

6

[diagnosis: pituitary cell type]

gigantism (children), acromegaly (adults)

Somatotroph

hormone: GH

7

[diagnosis: pituitary cell type]

cushing syndrome, presence of large, nelson syndrome

Corticotroph

hormone: ACTH

8

___ syndrome

destructive adenoma after adrenalectomy for treatment of cushing syyndrome

Nelson syndrome

9

[diagnosis: pituitary cell type]

Hyperthyroidism

Thyrotroph

Hormone: TSH

10

[diagnosis: pituitary cell type]

Hypogonadism, mass effect, hypopituitarism

Gonadotroph

Hormone: FSH, LH

11

[diagnosis: pituitary]

uniform, polygonal cells in sheets and cords, sparse reticulin network, invasion and increased mitosis: atypical adenomas

pituitary adenoma

12

[diagnosis: pituitary]

atypical adenomas + metastasis (CSF/systemic)

pituitary CA

13

hormone that is lost first following hypopituitarism

FSH and LH

14

hormone that is lost last following hypopituitarism

prolactin

15

[diagnosis: pituitary hormone deficiency]

amenorrhea, infertility, decreased libidi, impotence, loss of pubic and axillary hair

FSH, LH

16

[diagnosis: pituitary hormone deficiency]

pallor

MSH

17

[diagnosis: pituitary syndromes]

Serum Na: increased
Plasma Osm: increased
Urine Na: decreased
Urine Osm: Decreased

UO increased
CVP decreased

ADH is low

Central DI

18

[diagnosis: pituitary syndromes]

Serum Na: increased
Plasma Osm: increased
Urine Na: decreased
Urine Osm: Decreased

UO increased
CVP decreased

ADH is high

nephrogenic DI

due to unresponsiveness of renal tubules to ADH

19

[diagnosis: pituitary syndromes]

Serum Na: low
Plasma Osm: low
Urine Na: high
Urine Osm: high

UO low
CVP high

ADH is high

SIADH

20

[diagnosis]

vestifgial remnant of rathke pouch, mass effect, compress pituitary parenchyma

craniopharyngioma

21

[diagnosis: pituitary]

nest of squamous cells with peripheral palisading around a spongy reticulum

tumor nests float on wet keratin

cranipharyngioma

22

most common cause of congenital hypothyroidism world wide

iodine deficiency

23

most common cause of hypothyroidism in iodine-sufficient areas

Hashimoto Thyroiditis

24

[diagnosis]

infancy to early childhood, impaired CNS development, short stature, coarse facial features, protruding tongue, umbilical hernia

cretinism

25

[diagnosis]

late adulthood to adult, slowing of physical activity, overweight, hypercholesterolemia, non-pitting edema, coarse facial features, macroglossia, deepening of voice

myxedema

26

[diagnosis]

fibrosis of the thyroid gland + contiguous neck structures

Reidel Thyroiditis

27

[diagnosis]

hyperplastic follicles forming pseudopapillary structures, moth eaten colloid

graves ophthalmopathy

28

[diagnosis]

painless goiter, transient hyperthyroidism then hypothyroidism

autoantibodies against TG and TPO

hashimoto thyroiditis

29

[diagnosis]

painless goiter, transient hyperthyroidism then hypothyroidism

autoantibodies against TPO; usually associated with a history of autoimmune disease

Subacute Lymphocytic or postpartum

30

[Diagnosis]

painful, variable thyroid enlargement, transient hyperthyroidism then hypothyroidism then normal

antigen-mediated immune damage to follicular cells (by cytotoxic T cells)

notable history of URTI

Granulomatous