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Apex Review > Coagulation 6 > Flashcards

Coagulation 6 Flashcards

(49 cards)

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1
Q

Match each medication with its MOA.
Clopidogrel, warfarin, abciximab, enoxaparin
antithrombin cofactor, ADP receptor antagonist, vitamin K antagonist, GpIIB/IIIa receptor antagonist

A

clopidogrel- ADP receptor antagonist
warfarin- vitamin K antagonist
enoxaparin- antithrombin cofactor
Abciximab- GpIIb/IIIa receptor antagonist

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2
Q

Drugs that increase bleeding can be broken down into

A

antiplatelet drugs
anticoagulant drugs
fibrinolytics

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3
Q

Fibrinolytic drugs include

A

plasminogen activators

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4
Q

Plasminogen activators are

A

tPA
streptokinase

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5
Q

Anticoagulant drugs include

A

heparins
thrombin inhibitors
factor 10 inhibitors
vitamin K antaognists

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6
Q

tPA should be stopped _____ before procedures

A

1 hour

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7
Q

Streptokinase should be stopped ________ before procedures

A

3 hours

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8
Q

Heparin should be stopped

A

6 hours before procedures

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9
Q

LMWH should be stopped __________ before procedures

A

1-2 days

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10
Q

Warfarin should be stopped

A

2-4 days before procedures

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11
Q

Factor 10 inhibitors include

A

Fondaparinux

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12
Q

Fondaparinux should be stopped __________ before procedures

A

4 days

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13
Q

Thrombin inhibitors include

A

argatroban
bivalirudin

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14
Q

Arogatroban should be stopped

A

4-6 hours before

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15
Q

Bivalirudin should be stopped

A

2-3 hours before

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16
Q

Antiplatelet drugs include

A

ADP receptor inhibitors
GPIIb/IIIa receptor antagonists
Cox inhibitors (non-specific)
Cox 2 inhibitors

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17
Q

Examples of ADP receptor inhibitors include

A

clopidogrel
ticlopidine
prasugrel
ticagrelor

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18
Q

Ticagrelor & clopidogrel should be stopped

A

5-7 days before procedures

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19
Q

Ticlopidine should be stopped

A

14 days beforee

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20
Q

Prasugrel should be stopped

21
Q

GpIIb/IIIa receptor antagonists include

Study These Flashcards
A

abciximab
eptifabtide
tirofiban

22
Q

Tirofiban & eptifabitide should be stopped

Study These Flashcards
A

1 day before surgery

23
Q

Abciximab should be stopped

Study These Flashcards
A

3 days before surgery

24
Q

Aspirin should be stopped

Study These Flashcards
A

7 days before surgery

25
NSAIDs should be stopped
1-2 days before surgery
26
Celebrex should be stopped
doesn't need to be!
27
Non-specific cox inhibitors work by
blocking COX-1 which stops the conversion of arachidonic acid to prostaglandins and ultimately thromboxane A2
28
COX 2 inhibitors affect on platelet function
they do not affect platelt function
29
Plasminogen activation inhibitors include
aminocaproic acid & tranexamic acid
30
Desmopressin stimulates
factor 8 and vWF factor release
31
Aprotinin inhibits
plasmin, thrombin, protein C, and kallikrein
32
TXA works on the
lysine binding sites on plasminogen
33
A patient scheduled for coronary revascularization is diagnosed with type 3 von Willebrand disease. What is the BEST treatment for this patient? a. DDAVP b. platelets c. cryoprecipitate d. vWF/factor 8 concentrate
d. vWF/factor 8 concentrate
34
The most common inherited disorder of platelet function is
Von Willebrand disease
35
Von Willebrand disease is a __________ platelet disorder
qualitative; platelet count is normal, but the platelets do not function properly
36
Lab abnormalities of Von Willebrand disease include
increased PTT and bleeding time
37
Von willebrand factor (MOA
anchors the platelet to the vessel wall at the site of vascular injury & carries inactivated factor 8 in the plasma
38
_______ & __________________ contain factors 8 and vFW and can be used for all 3 types of vFW disease
Cryo & FFP
39
The first-line agent for the patient with type 3 vWF disease is
Purified 8-vWF concentrate
40
Purified 8-vWF concentrate reduces the risk of
transfusion-related infection
41
Patients with type 1 vWF disease respond best to
desmopressin
42
Desmopressin stimulates the
release of endogenous vWF and increases factor 8 activity
43
Patients with type 3 vWF disease do not
respond to desmopressin b/c they don't produce vWF
44
The desmopressin dose is
0.3 mcg/k IV
45
Von Willebrand factor is synthesized by
vascular endothelium and megakaryocytes
46
What are the three classifications of von Willebran disease?
type 1: mild-moderate reduction in the amount of vWF-produced type 2: the vWF that is produced doesn't work well type 3: severe reduction in the amount of vWF produced
47
After using desmopressin, bleeding time is improved for
12-24 hours
48
Side effects of desmopressin include
vasodilation--> hypotension with rapid administration hyponatremia d/t free water retention
49
What coagulating factors are in cryo?
fibrinogen 8 & 13 vWF

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