Miscellaneous topics 7 Flashcards

1
Q

Deflation of the pneumatic tourniquet during orthopedic surgery is expected to increase:
a. blood pressure
b. mixed venous oxygen saturation
c. end-tidal carbon dioxide
d. blood pH

A

c.

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2
Q

______________________ increases intramedullary pressure in the bone and this can produce microemboli that travel to the lungs.

A

Methyl methacrylate

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3
Q

Methyl methacrylate that produces microemboli that can travel to the lungs can result in

A

V/Q mismatch and potentiate right heart failure

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4
Q

Residual methyl methacrylate can enter the systemic circulation where it causes

A

bradycardia, dysrhythmias, systemic hypotension, pulmonary hypertension, hypoxia, and cardiac arrest

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5
Q

Methyl methacrylate entering the systemic circulation is known as

A

bone cement implantation syndrome (BCIS)

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6
Q

__________ is a recognized complication of long bone trauma

A

Fat embolism syndrome

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7
Q

The triad of fat embolism syndrome includes

A

respiratory insufficiency, neurologic changes, and a petechial rash

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8
Q

To reduce the risk of limb ischemia when using a pneumatic tourniquet, the maximum inflation time is

A

two hours

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9
Q

When used for a bier block, the tourniquet must remain inflated for at least

A

20 minutes after LA is injected

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10
Q

Premature release of LA after a bier block can lead to

A

seizures and/or cardiac arrest

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11
Q

Under general anesthesia, tourniquet pain manifests as

A

hypertension and tachycardia

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12
Q

Deflating the pneumatic tourniquet causes a

A

redistribution of circulating blood volume and exposes the body to the washout of metabolites that accumulated during limb ischemia

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13
Q

___________ is associated with the highest risk of bone implementation syndrome

A

Hip arthroplasty

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14
Q

In the awake patient under regional anesthesia, the first signs of BCIS are usually

A

dyspnea and AMS

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15
Q

Under GA, the first sign of BCIS is usually

A

a decreased EtCO2

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16
Q

First line treatment of BCIS is

A

100% FiO2
IV hydration
phenylephrine for hypotension

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17
Q

Risk factors for fat emboli syndrome include

A

pelvic fracture
femoral fracture
instrumentation of the femoral medullary canal

18
Q

Releasing the tourniquet produces transient changes that include

A

increased EtCO2
decreased core body temperature
decreased blood pressure
decreased SvO2 (SaO2 is usually normal)
metabolic acidosis

19
Q

Tourniquet pain is transmitted by

20
Q

What is the best way to treat intractable pain when using an orthopedic tourniquet in a patient with a neuraxial block?

A

convert to GA. this type of pain is unresponsive to analgesics

21
Q

All of the following are associated with Samter’s triad EXCEPT:
a. allergic rhinitis
b. bronchospasm
c. nasal polyps
d. hypertension

A

d. Hypertension

22
Q

Inhibition of Cox-1 enzyme does the following three things:

A

impairs platelet function
causes gastric irritation
reduces renal blood flow

23
Q

Inhibition of the COX-2 enzyme produces

A

analgesia
anti-inflammation
antipyretic effects

24
Q

Aspirin inhibits

A

COX-1 & COX-2 irreversibly

25
Aspirin-exacerbated respiratory disease (Samter's triad) refers to the combination of
asthma allergic rhinitis nasal polyps which can cause life threatening bronchospasm following administration
26
Toradol 30 mg IV is equivalent to morphine ________
10 mg IV
27
Acetaminophen is __________ an NSAID
NOT!
28
The most common cause of acute liver failure in the US is
acetaminophen
29
The max dose of acetaminophen is
4g/day
30
What NSAIDs have cox 2 selective inhibition?
Celecoxib any drug that ends with -coxib
31
What are the key CV complications of NSAIDs?
increased risk of HTN, MI & HF (COX 2 inhibitors> Cox-1 inhibitors)
32
What are the key hematologic complications of NSAIDs?
platelet inhibition--> increased bleeding risk
33
Ketorolac can only be taken for
5 days
34
Aspirin toxicity can cause a
gap metabolic acidosis
35
List 6 drugs that inhibit the COX-2 pathway.
aspirin ibuprofen naproxen ketorolac diclofenac indomethacin
36
Herbal medicines that increase bleeding tendencies include
garlic ginger ginko biloba ginseng
37
Are herbal medicines contraindications to regional anesthesia?
no as long as the patient is not on other anticoagulant medications
38
Herbs that reduce MAC include
kava kava & valerian
39
Complications of ephedra-containing compounds (Ma Huang) include
SNS effects catecholamine depletion increased risk of serotonin syndrome when co-administered with MAOIs
40
St. John's wort may
prolong duration of anesthetic agents & lead to serotonin syndrome with interaction with MAOIs and meperidine