Liver 2 Flashcards
(47 cards)
Hepatocytes produce: (select 3)
a. thrombopoietin
b. alpha-1-acid glycoprotein
c. immunoglobins
d. factor 3
e. factor 7
f. factor 8
a. thrombopoietin
b. alpha-1 acid glycoprotein
e. factor 7
The liver plays an essential role in
protein synthesis
The liver plays a vital role in metabolism of
carbs, proteins, and lipids
The liver produces all of the clotting factors with the exception of
factor 3, factor 4, and von Willebrand factor
Vitamin K-dependent clotting factors include
factors 2, 7, 9, 10
Proteins C, S, and Z
The liver produces all the plasma proteins with the exception of
immunoglobulins
_________ is the most abundant plasma protein.
Albumin
Albumin serves as a blood reservoir for _______drugs
acidic
Alpha-1 acid glycoprotein is a blood reservoir for _________drugs
basic
_____________________increases the duration of succinylcholine and possibly increases the duration of ester- type local anesthetics.
Reduce pseudocholinesterase production
Reduced pseudocholinesterase production is only a problem with
severe liver disease
____________ is a byproduct of protein metabolism
Ammonia
Failure to clear ammonia (hepatic failure or portosystemic shunting) leads to
hepatic encephalopathy
__________ is a byproduct of hemoglobin metabolism.
Bilirubin
Unconjugated bilirubin is
neurotoxic
Unconjugated bilirubin is conjugated with ___________ in the liver, which hastens its elimination from the body
glucuronic acid
the liver plays a vital role in __________—
drug biotransformation
______________- is produced by the liver sinusoidal cells and endothelial cells (not by hepatocytes)
factor 8
In addition to the clotting factors, the liver also produces
antithrombin (anticoagulant)
plasminogen (fibrinolytic)
thrombopoietin (stimulates platelet production)
The liver is an important regulator of serum
glucose
Patients with liver failure are at risk of
hypoglycemia b/c it the liver is responsible for clearing insulin from the circulation
Hyperglycemia leads to the release of _________ by _________- in a metabolic process known as
insulin by pancreatic beta cells; glycogenesis
Hypoglycemia leads to the release of
glucagon via pancreatic alpha cells
epi via the adrenal medulla
How is unconjugated bilirubin created?
hemoglobin is broken down in spleen to heme–> unconjugated bilirubin
